Swartz Analytical Techniques in Combinatorial Chemistry

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Products/technologies: Utilizes its combinatorial chemistry libraries for the discovery of novel, small-molecule drug therapies in its internal discovery programs, in collaboration with pharmaceutical companies and in joint discovery alliances with biotechnology firms. Results of their combinatorial research agreement with Torrey Pines Institute for Molecular Studies (TPIMS) have included a range of inventions including PositionalScan, a method for identifying active compounds from mixture-based libraries.

Contact: Susan Adler, Senior Director, Business Development

Tripos, Inc.

1699 S. Hanley Road, St. Louis, MO 63144, USA Phone: [phone]; Fax: [phone] Toll-free in U.S.: [phone]

E-mail: [e-mail] Internet: http:/ /www.tripos.com

Profile: Founded in 1979, the company is a developer of molecular modeling and computational chemistry software that focuses on pharmaceuticals and biotechnology. Its Accelerated Discovery Services division provides a range of research services, including library design, to comprehensive discovery collaborations. In November 1997, the company announced the acquisition of Receptor Research Ltd., a UK-based company specializing in custom synthesis using solid phase chemistry for biological applications. The acquisition will allow Tripos to directly apply its molecular informatics, design, and analysis expertise in new compound discovery collaborations in the pharmaceutical, biotechnology, agrochemical, and related industries.

Products/technologies: Chemical diversity technology is used to design libraries with high structural variation. The company supplies drug discovery services, chemical compounds, and scientific software to facilitate the discovery of new therapeutic and bioactive compounds in pharmaceutical, biotechnology, chemical, and agrochemical industries. ChemSpace proprietary technology is used for the design and analysis of combinatorial libraries and related data; the ChemSpace virtual database of over one trillion synthetically accessible, small organic chemical structures provides a platform from which screening and focused chemical libraries can be designed and managed. Combinatorial chemistry software applications add on to its traditional Sybyl software for molecular modeling and analysis, along with Unison Windows

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software for desktop data access and management. Legion is a combinatorial

chemistry application, and Selector provides software tools for managing and analyzing chemical diversity. Tripos/Panlabs offers Optiverse , a standard

compound screening library, that includes integrated design and synthesis for optimal lead discovery and lead refinement.

Contact: Dr. John P. McAlister, President and CEO

Varian Associates, Inc.

3050 Hansen Way, Palo Alto, CA 94304-1000, USA Phone: [phone]; Fax: [phone] Toll-free in U.S.: [phone]

Internet: http:/ /www.varian.com

Stock: VAR (NYSE)

Profile: Varian is a billion dollar high-technology company. As a diversified, international electronics company, it designs, manufactures, and markets hightech systems and components for applications in worldwide markets. It is organized around three core businesses that include semiconductor equipment, healthcare systems, and instruments. Its instruments group supplies analytical and research instrumentation and related equipment for chemical composition studies of myriad substances. Additionally, this operation manufactures vacuum products, helium leak detectors, and solid phase extraction sample preparation products that are used for chemical isolation and purification. The company acquired the assets of Dynatech Precision Sampling Corporation, a manufacturer of several autosampling devices for LC and GC. In early 1997 it also acquired the LC line of Rainin Instrument Company, Inc.

Products/technologies: These include solid phase extraction products in 96-well format; and Mercury , which is a small, low-cost NMR spectrometer.

The acquisition of Rainin allows Varian to compete in the preparative HPLC market and gives it a lower cost product line to complement its research grade LC systems.

Versicor Inc.

270 E. Grand Avenue, South San Francisco, CA 94080, USA Phone: [phone]; Fax: [phone]

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Profile: Versicor Inc., a majority-owned subsidiary of Sepracor Inc. (Nasdaq: SEPR), is a second-generation company that integrates biology/genomics, combinatorial chemistry, high-throughput screening, and informatics in a balanced format to discover new anti-infective drugs against resistant pathogens.

Products/technologies: Screening and synthesis of chemical libraries, highthroughput assay development, and lead validation.

Contact: Jonae R. Barnes, Manager, Corporate Communications

Waters Corporation

34 Maple Street, Milford, MA 01757, USA Phone: [phone]; Fax: [phone] Toll-free in U.S.: (800) 252-HPLC

E-mail: brian_ [e-mail] Internet: http:/ /www.waters.com

Stock: WAT (NYSE)

Profile: Waters is the largest company in the analytical instrument industry devoted to HPLC (instrumentation, consumables, and associated postsale support services) and related technologies. The company has held the leadership position in HPLC for more than 35 years, with the pharmaceutical industry being Waters’ largest single market. Its HPLC and LC-MS systems are ideally suited for combinatorial analysis. In addition to leading in the $2.1 billion HPLC market, the company has also expanded its product and technology offerings through several recent acquisitions. Acquisitions in 1997 included Micromass Limited (Manchester, England), a technology leader in the areas of magnetic sector, time-of-flight, and quadrupole geometry mass spectrometers, and the largest supplier of benchtop MS instruments, including systems for combinatorial screening and rapid purification of drug candidates. Also acquired in 1997 was YMC Inc. (Wilmington, NC), the North American distributor of YMC brand columns and bulk packing materials. Sales to international customers account for more than 60% of total revenues.

Products/technologies: The Waters LC-MS solutions for drug discovery consist of a Waters Alliance HPLC system (with optional 996-photodiode array or 2487 UV/Vis detectors), Waters 2700 Sample Manager (for 96-well microtiter plates), Micromass Platform LC or Platform LCZ benchtop API mass spectrometer, and MassLynx software with special options for combinatorial

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chemistry, such as OpenLynx Diversity and FractionLynx . Waters also provides columns and sample preparation products, such as Symmetry , SymmetryShield , and Oasis HLB cartridges and extraction plates, that are designed for high-throughput drug assays and preparative applications.

Contact: Brian J. Murphy, Corporate Communications

Xenometrix, Inc.

2425 North 55th Street, Suite 111, Boulder, CO 80301-5700, USA Phone: [phone]; Fax: [phone]

Toll-free in U.S.: (800) 4DNATOX E-mail: [e-mail] Internet: http:/ /www.xeno.com.

Profile: A biotechnology company with proprietary technology, Xenometrix helps the pharmaceutical industry improve the effectiveness of drug discovery and development.

Products/technologies: Unique gene response profiles provide mechanistic information that can be used to optimize drug leads, as well as automated assays for screening drug leads for safety. Tools are offered as kits for customers to perform in their own laboratories or as a service through Xenometrix’s Customer Research Laboratory.

Contact: Stephen J. Sullivan, President and CEO

Xenova Group plc

240 Bath Road, Slough, Berkshire SL1 4EF, UK Phone: [phone]; Fax: [phone] Internet: http:/ /www.xenova.co.uk

Stock: XNVAY (NASDAQ)

Profile: Founded in 1986, Xenova went public in 1994. The company provides rapid, efficient, and cost-effective routes to discovering novel drugs where there is no obvious chemical starting point.

Products/technologies: The company has diverse libraries of natural compounds prepared from plant, fungal, and microbial sources; and proprietary

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processes for the isolation and characterization of individual compounds, which are compatible with modern high-throughput screening technologies.

Contact: Dr. Louis Nisbet, CEO

YMC, Inc.

3233 Burnt Mill Drive, Wilmington, NC 28403, USA Phone: [phone]; Fax: [phone] Toll-free in U.S.: (800) YMC-6311

E-mail: [e-mail] Internet: http:/ /www.ymc-hplc.com

Profile: YMC, Inc. manufactures and supplies YMC brand HPLC columns and bulk packing materials. It was founded as a joint venture company in 1985 with Yamamura Chemical Laboratory Co. Ltd. (YMC Co. Ltd.) as the North American distributor. Waters Corporation has held an equity position in YMC Co. Ltd. since 1987, and in 1997 it acquired YMC, Inc. Waters trades as WAT on the NYSE.

Products/technologies: The CombiChrom columns provide HPLC analysis and purification of diverse mixtures. Also, CombiScreen columns are used for one-step scale-up for fast analysis and high throughput; and CombiPrep

columns are designed for one-step scale-up for purification of complex mixtures.

Contact: Jim Carroll

Zymark Corporation

Zymark Center, Hopkinton, MA 01748, USA

Phone: [phone]; Fax [phone]

E-mail: [e-mail]

Internet: http:/ /www.zymark.com

Profile: Founded in 1981, Zymark is a leader in laboratory automation for the pharmaceutical, biotechnology, and chemical industries. Having pioneered the technology, the company serves drug discovery research, bioanalytical development, formulations development, and quality control functions. In 1994 Zymark transitioned from a technology-based product business to a laboratory

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automation solutions business. The focus is on providing solutions to companies to improve lab productivity by integrating technology, support, consulting services, and project management. In September 1996, Zymark became a member of the Berwind Group of companies. The Berwind Group is a highly diversified, family-owned enterprise, consisting of a number of independently managed businesses.

Products/technologies: In the area of discovery research, the company offers microassay technologies including high-throughput screening sstems for a range of biological assays (the Zymate immunoassay system, cell-based assay systems, and receptor binding systems); compound preparation and distribution systems, and automated organic synthesis systems. Zymark’s RapidPlate96 workstation simultaneously transfers to and from 96 wells of a microplate. The company also has designed a software interface, the PCS productivity, communications, and scheduling software that can be customized to customer needs. The Allegro ultrahigh-throughput screening technology applies automation and assay technologies in a production line architecture that allows screening of 100,000 assay points per day.

Contact: Kenneth N. Rapp, Vice President, Sales