Sodium Channels and Neuronal Hyperexcitability

Sodium Channels and Neuronal Hyperexcitability.

Novartis 241

Copyright & 2002 JohnWiley & Sons Ltd

Print ISBN 0-471-48530-6 Online ISBN 0-470-84668-2

SODIUM CHANNELS AND NEURONAL HYPEREXCITABILITY

Sodium Channels and Neuronal Hyperexcitability.

Novartis 241

Copyright & 2002 JohnWiley & Sons Ltd

Print ISBN 0-471-48530-6 Online ISBN 0-470-84668-2

Copyright &Novartis Foundation 2002

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Novartis Foundation Symposium 241 viii+244 pages, 42 ¢gures, 5 tables

Library of Congress Cataloging-in-Publication Data

Sodium channels and neuronal hyperexcitability / [editors], Gregory Bock, Jamie A. Goode. p. cm. ^ (Novartis Foundation symposium ; 241) (Ciba Foundation symposium)

Includes bibliographical references and index. ISBN 0-471-48530-6 (alk. paper)

1. Sodium channels ^Congresses. 2. Molecular neurobiology^Congresses. 3. Nervous

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A catalogue record for this book is available from the British Library

ISBN 0 471 48530 6

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Lori L. Isom b subunits: players in neuronal hyperexcitability? 124

Discussion 138

Stuart Bevan and Nina Storey Modulation of sodium channels in primary a¡erent neurons 144

Discussion 153

John N.Wood, Armen N. Akopian, Mark Baker,Yanning Ding,

Fleur Geoghegan, Mohammed Nassar, Misbah Malik-Hall, Kenji Okuse, Louisa Poon, Samantha Ravenall, Madhu Sukumaran and

Veronika Souslova Sodium channels in primary sensory neurons: relationship to pain states 159

Discussion 168

Michael M. Segal Sodium channels and epilepsy electrophysiology 173

Discussion 180

Gary R. Strichartz, Zhongren Zhou, Catherine Sinnott and Alla Khodorova Therapeutic concentrations of local anaesthetics unveil the potential role of sodium channels in neuropathic pain 189

Discussion 202

William A. Catterall Molecular mechanisms of gating and drug block of sodium channels 206

Discussion 218

Final general discussion 226

Index of contributors 233

Subject index 235

Lori L. Isom Department of Pharmacology,The University of Michigan Medical School, 1301MSRB III, 1150 W. Medical Center Drive, Ann Arbor, MI 48109-0632, USA

Richard Keynes Department of Physiology, University of Cambridge, Downing Street, Cambridge CB2 3EG, UK

Miriam Meisler Department of Human Genetics, University of Michigan Medical School, Ann Arbor, MI 48109-0618, USA

Je¡rey L. Noebels Department of Neurology, Baylor College of Medicine, One Baylor Plaza, Houston,TX 77030, USA

Louis Ptacek Howard Hughes Medical Institute, University of Utah School of Medicine, Room 4425, Salt Lake City, UT 84112-5331, USA

Indira M. Raman Department of Neurobiology and Physiology, Northwestern University, 2153 North Campus Drive, Evanston, Illinois 60208-3520, USA

Michael Segal Harvard Medical School and Brigham & Women’s Hospital, Longwood Medical Research Center, 221 Longwood Ave, Boston MA 02115, USA

Nelson Spruston Department of Neurobiology and Physiology, Northwestern University, 2153 N. Campus Drive, Evanston, IL 60208-3520, USA

Gary R. Strichartz Pain Research Center, Harvard Medical School, Anaesthesia Research Laboratories, Medical Research Building 611, Brigham and Women’s Hospital, 75 Francis Street, Boston, MA 02115, USA

StephenWaxman (Chair) Department of Neurology,Yale Medical School, 333 Cedar Street, LCI-707, New Haven, CT 06510, USA

JohnWood Department of Biology, University College London, Medawar Building, Gower Street, LondonWC1E 6BT, UK