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J. Shah and S. Iyer

 

 

Malignant hyperthermia (MH)

MH is a specific inherited muscle membrane disorder.

It causes a dangerous hypermetabolic state after anesthesia with suxamethonium and/or volatile halogenated anesthetic agents.

Dantrolene sodium is a specific antidote and induces flaccidity of muscle due to inhibition of excitation–contraction coupling in skeletal muscle.

Endocrine abnormalities

Thyrotoxic crisis

Suggested Reading

1.Mace SE. Central nervous system infections as a cause of an altered mental status? What is the pathogen growing in your central nervous system? Emerg Med Clin North Am. 2010; 28(3):535–70.

A practical review of managing CNS infections.

2.Honda H, Warren DK. Central nervous system infections: meningitis and brain abscess. Infect Dis Clin North Am. 2009;23(3):609–23.

This article reviews the common infectious etiologies of central nervous system infections, especially bacterial meningitis and brain abscess, and their subsequent management in the intensive care unit.

3.Ziai WC, Lewin JJ III. Update in the diagnosis and management of central nervous system infections. Neurol Clin. 2008;26(2):427–68.

This review focuses on early aggressive management of common infections of the central nervous system that require monitoring in an ICU setting.

4.Zunt JR, Marra CM. Cerebrospinal fluid testing for the diagnosis of central nervous system infection. Neurol Clin. 1999;17(4):675–89.

This article discusses how these CSF tests are performed and addresses the sensitivity and specificity of such tests for the diagnosis of selected CNS infections.

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