Добавил:
Опубликованный материал нарушает ваши авторские права? Сообщите нам.
Вуз: Предмет: Файл:

DB European Pharmaceuticals 2019 Outlook_watermark

.pdf
Скачиваний:
10
Добавлен:
06.09.2019
Размер:
2.95 Mб
Скачать

vk.com/id446425943

Deutsche

Summary model

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Figure 89 : Genmab summary P&L

 

 

 

 

 

 

 

 

Bank

DKKm ex-per share

2016A

2017A

2018E

2019E

2020E

2021E

2022E

2023E

 

 

 

 

 

 

 

 

 

 

 

AG/London

Revenues

1,816

2,365

2,903

3,915

5,172

7,053

8,623

9,635

EBIT

1,053

1,344

1,333

1,770

2,549

4,055

5,318

5,985

 

Growth

60%

30%

23%

35%

32%

36%

22%

12%

 

Total operating expenses

(763)

(1,021)

(1,570)

(2,145)

(2,623)

(2,973)

(3,241)

(3,535)

 

Margin

58%

57%

46%

45%

49%

57%

62%

62%

 

Net financial income

77

(280)

250

202

247

323

411

513

 

Profit before tax

1,130

1,064

1,583

1,972

2,796

4,378

5,729

6,498

 

Taxes

57

40

(348)

(434)

(615)

(963)

(1,260)

(1,430)

 

Tax rate

-5%

-4%

22%

22%

22%

22%

22%

22%

 

Net Income

1,187

1,104

1,235

1,538

2,181

3,415

4,469

5,068

 

Wtd Average Shares

59.9

60.8

61.3

61.7

62.0

62.3

62.6

62.9

 

Basic EPS

19.8

18.1

20.2

24.9

35.2

54.8

71.4

80.6

 

Source: Deutsche Bank, Company data

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Figure 90 : 2019E divisional revenue split

 

Figure 91 : Sales and EPS growth 2016A-2023E

 

 

 

Reimbursement

Arzerra royalty

 

12,000

 

 

 

 

 

 

90

 

inc.

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

1%

 

 

 

 

 

 

 

 

 

 

5%

 

 

 

 

 

 

 

 

80

 

 

 

 

 

 

 

 

 

 

 

Milestone payments

 

 

10,000

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

70

 

21%

 

M

 

 

 

 

 

 

 

 

(DKK)EPS

 

 

DKKEUNEVE

8,000

 

 

 

 

 

 

60

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

50

 

 

 

 

6,000

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

40

 

 

 

R

 

 

 

 

 

 

 

 

 

 

 

 

4,000

 

 

 

 

 

 

30

 

 

 

 

 

 

 

 

 

 

 

20

 

 

 

 

2,000

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

10

 

 

Darzalex royalty

 

-

 

 

 

 

 

 

0

 

 

 

2016A

2017A

2018E

2019E

2020E

2021E

2022E

2023E

 

 

73%

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

REVENUE

 

 

 

EPS

 

 

Source: Deutsche Bank

 

Source: Deutsche Bank, Company data

 

 

 

 

 

 

 

51 Page

2018 December 10 Pharmaceuticals Pharmaceuticals European

vk.com/id446425943

Page

Swedish Orphan Biovitrum (Upgrade to Buy; PT

52

SEK245)

 

Sobi is undergoing a strategic transformation

We are upgrading Sobi to Buy as we believe the transformational nature of recent acquisitions is yet to be fully reflected in the shares. The acquisitions of Synagis and Gamifant build scale and critical mass to Sobi's US specialty business, diversify its profits from hemophilia and give it the P&L flexibility to reinvest in building its pipeline. We continue to believe its hemophilia franchise o ers durable growth potential in the medium term even with increased competition. In our view the shares 15x 2019 PER does not fairly reflect the company's solid near-term growth prospects ('18-22 EPS CAGR =14%) or the opportunity for management to leverage its strengthened platform through further business development.

Continued Hemophilia franchise rollout and Gamifant should drive solid medium term growth. With Elocta market share still only in low double digits, we believe European sales of Sobi's long acting hemophilia franchise can easily still grow by >50% in the coming years. We remain optimistic that a potential launch of BIVV001 and use of Elocta in immune tolerance induction (ITI) could help Sobi defend these sales in the face of competition in the longer term. Importantly, the expected launch of Gamifant and the acquisition of Synagis rights means that ~45% of our 2024E profits are derived from durable franchises less exposed to competitive risks.

Increasing PT to SEK245 (up from SEK200). We have increased our Core EPS forecasts by 1-5%, reflecting increases to our Gamifant forecasts. Given increased confidence in the sustainability of Sobi's growth prospects we now base our price target solely on our DCF with an increased terminal growth rate (2% vs 0%). This TGR is in-line with the assumption for the majority of our research coverage. Key risks include a weaker switch to longacting clotting factors, greater competition from new hemophilia therapies and disappointing sales of Gamifant.

 

Figure 92 : Bull/bear target price impact (SEK/share)

 

 

Figure 93 : Sobi NPV valuation

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Product

Phase

Launch

Peak sales

Probability

NPV (SEKm)

NPV (US$m)

NPV/Share

% of total

 

320

 

 

 

 

 

 

 

 

 

 

(SEKm)

 

 

 

(SEK)

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

13

280

Kineret

Approved

Launched

1,654.2

100%

6,959.4

814.4

23.56

10%

 

 

 

 

 

 

 

 

 

 

 

 

 

 

5

 

 

Other

Approved

Launched

964.0

100%

1,523.6

178.3

5.16

2%

 

270

 

24

 

17

 

 

 

Orfadin

Approved

Launched

905.1

100%

1,886.3

220.7

6.39

3%

 

 

 

245

 

 

 

 

Refacto

Approved

Launched

656.2

100%

819.1

95.9

2.77

1%

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Synagis franchise

Approved

Launched

2,833.5

100%

14,140.7

1,654.8

47.87

19%

 

 

33

 

 

 

 

 

 

Gamifant

Approved

2019

2,750.0

100%

9,609.9

1,124.6

32.54

13%

 

220

 

 

 

 

 

 

 

Core business NPV

 

 

 

 

34,939.0

4,088.8

118.3

48%

 

 

 

 

 

 

 

 

 

 

 

 

 

 

188

 

 

 

 

 

 

 

Eloctate

Approved

Launched

5,152.6

100%

25,185.4

2,947.4

85.27

35%

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Alprolix

Approved

Launched

1,516.5

100%

10,106.6

1,182.7

34.22

14%

 

170

 

 

 

 

 

 

 

Hemophilia NPV

 

 

 

 

35,292.0

4,130.1

119.5

49%

 

 

 

 

 

 

 

 

Technology/pipeline value

 

 

 

9,838.3

1,151.3

33.3

14%

Deutsche

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Net cash (debt)

 

 

 

 

-7,543.9

-882.8

(25.54)

-10%

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Total

 

 

 

 

72,525.4

8,487.4

245.5

100%

 

120

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Bank

70

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Bear

No pipeline

Elocta

Base

Elocta better

Better

Better

Bull

 

 

 

 

 

 

 

 

 

AG/London

 

 

erosion from

 

LT outlook

Synagis

Gamifant

 

 

 

 

 

 

 

 

 

 

 

 

2020

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Source: Deutsche Bank, * - current share price

 

 

 

 

 

Source: Deutsche Bank

 

 

 

 

 

 

 

 

2018 December 10 Pharmaceuticals Pharmaceuticals European

vk.com/id446425943

Deutsche

 

Support for change in recommendation

 

Launch of Gamifant in early 2019 diversifies Sobi's growth prospects. We expect Sobi to launch its new treatment for primary haemophagocytic

 

 

Bank

 

 

lymphohistiocytosis (HLH) in early 2019. Sobi has yet to disclose its pricing strategy. Although the initial US sales opportunity in refractory cases

 

 

of primary HLH is in theory modest, expert feedback suggests positive experiences with the drug and suggests it is likely to ultimately become

AG/London

 

 

established as treatment option for all primary and secondary HLH cases. It seems unlikely that reimbursement will be limiting to this uptake given lack

 

 

 

 

 

 

of clear standard-of-care and poor outcomes with current treatment. We expect Sobi to instigate e orts to improve currently poor rates of diagnosis

 

 

 

and expand the drug's potential into other settings where interferon gamma has a key role in hyperinflammation. Our model assumes Sobi's target

 

 

 

of $300m in sales is achieved by 2024E contributing to 13% of NPV.

 

 

Limited impact from Hemlibra launch expected; meaningful growth potential remains. The potential for paradigm change in the treatment of

 

 

 

hemophilia remains a risk to consensus forecasts for Sobi's long acting Factor VIII franchise. The recent expanded approval of Hemlibra could begin

 

 

 

to have impact on US sales in 2019 (and impact Sobi royalties). However, expert feedback continues to suggest the transition to new therapies in

 

 

 

hemophilia will take time given caution over safety and the fact that the majority of patients are well controlled on current therapy (see notes here and

 

 

 

here ). We expect limited direct impact from Hemlibra launches in Sobi's core European markets before 2020 given need for further reimbursement

 

 

 

access negotiations following an expected expanded approval in 1H19. In addition, we estimate that Elocta currently has only a modest ~12% market

 

 

 

share leaving significant opportunity for growth even with new competition. We remain optimistic that recent impressive data from a Phase I/II trial

 

 

 

of BIVV001 and first data from trials of Elocta in immune tolerance induction (ReITIrate due 4Q19) will help improve confidence that Sobi defend/

 

 

 

grow its hemophilia sales in the face of competition in the longer term.

 

 

Further business development seems likely. Since joining Sobi in early 2017, CEO Guido Oelkers has made it a priority to build critical mass in the

 

 

 

Company's US specialty business and ultimately strengthen the company's pipeline. We believe execution on these plans has been impressive to date

 

 

 

with the in-licensing of Gamifant and acquisition of Synagis giving scale to the US business and reducing the company's reliance on its hemophilia

 

 

 

portfolio. We suspect that this is not likely to be the end of management's business development plans. Further deals could seek to leverage this

 

 

 

strong foundation to drive shareholder value by expanding the company's pipeline.

 

 

 

 

 

 

 

Figure 94 : Potential news flow

 

 

 

 

Timing

 

Event

Description

 

 

2018

 

Corporate

Possible business development or M&A activity

 

2018

 

Orfadin

Impact of expected Orfadin generic launches in Europe and US

 

2018

 

C5 inhibitor

Possible start of clinical trials of novel long-acting C5 inhibitor using Fc fusion technology

 

 

November 20th

Emapalumab

FDA PDUFA action date

 

 

4Q18/1Q19

BIVV001

Final results of Phase I/II trial of once-weekly Factor VIII

 

2019

 

Kineret

Update on plans for Phase III trial in acute gout

 

2019-20

SOBI003

First results from Phase I trial of SOBI003 in Sanfilippo A syndrome (MPS IIIA)

 

2019

 

Kineret

Results from Phase III trial in Still's disease

 

 

4Q18/1Q19

Elocta

Results of 'Rescue ITI' trial (ReITIrate) in haemophilia A with inhibitors post ITI

 

 

Source: Deutsche Bank

 

 

 

 

 

 

 

 

53 Page

 

 

 

 

 

 

 

 

 

 

 

 

2018 December 10 Pharmaceuticals Pharmaceuticals European

vk.com/id446425943

54 Page

Summary model

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Figure 95 : SOBI summary P&L

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

SEKm ex-per share

2016A

2017A

2018E

2019E

2020E

2021E

2022E

2023E

 

 

 

 

 

 

 

 

 

 

 

Revenues

5,204

6,511

9,091

13,571

14,865

15,713

16,710

17,096

 

Gross profit

3,651

4,657

6,686

10,071

11,121

11,784

12,581

12,897

 

% of sales

70%

72%

74%

74%

75%

75%

75%

75%

 

SG&A (excl. amortisation)

(1,366)

(1,643)

(2,000)

(2,852)

(3,149)

(3,366)

(3,577)

(3,666)

 

R&D

(778)

(908)

(1,170)

(1,696)

(1,932)

(2,043)

(2,172)

(2,222)

 

Amortisation

(410)

(453)

(444)

(1,443)

(1,443)

(1,443)

(1,443)

(1,443)

 

EBITA

1,543

2,054

3,528

5,523

6,040

6,376

6,832

7,008

 

Margin (%)

30%

32%

39%

41%

41%

41%

41%

41%

 

PBT

1,048

1,533

3,064

3,656

4,183

4,541

5,023

5,226

 

Tax (expense)/benefit

(239)

(384)

(659)

(804)

(862)

(936)

(1,035)

(1,076)

 

Tax rate

23%

25%

22%

22%

21%

21%

21%

21%

 

Net Income

809

1,149

2,405

2,852

3,321

3,606

3,988

4,149

 

Basic EPS

3.02

4.27

8.90

9.66

11.20

12.11

13.34

13.82

 

Core EPS

4.08

5.51

10.16

13.42

15.01

15.91

17.12

17.58

 

Source: Deutsche Bank, Company data

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Figure 96 : 2019E revenue split

 

Figure 97 : Sales and EPS growth 2016A-2023E

 

 

 

 

Other

 

 

 

 

 

 

 

 

 

 

 

7%

 

18,000

 

 

 

 

 

 

20

 

 

 

 

16,000

 

 

 

 

 

 

18

 

 

Synagis

Elocta (EU)

14,000

 

 

 

 

 

 

16

 

 

19%

32%

 

 

 

 

 

 

 

 

 

SEKRENUEVEM

 

 

 

 

 

 

14

(SEK)EPSERO

 

 

 

 

 

 

 

 

 

 

 

 

12,000

 

 

 

 

 

 

 

 

 

 

 

10,000

 

 

 

 

 

 

12

 

 

 

 

 

 

 

 

 

 

 

 

 

Gamifant

 

 

 

 

 

 

 

 

10

 

 

1%

 

8,000

 

 

 

 

 

 

8

 

 

Orfadin

 

 

 

 

 

 

 

 

 

 

 

6,000

 

 

 

 

 

 

 

C

 

6%

 

 

 

 

 

 

 

6

 

 

 

 

 

 

 

 

 

 

 

 

 

 

4,000

 

 

 

 

 

 

4

 

 

 

 

 

 

 

 

 

 

 

 

Deutsche

 

 

2,000

 

 

 

 

 

 

2

 

 

Alprolix (EU)

-

 

 

 

 

 

 

0

 

 

 

 

 

 

 

 

 

 

 

Kineret

10%

 

 

 

 

 

 

 

 

11%

 

2016A

2017A

2018E

2019E

2020E

2021E

2022E

2023E

 

 

Refacto

Hemophilia

 

 

 

 

 

 

 

 

 

Bank

3%

royallties…

 

REVENUE

 

 

CORE EPS

 

 

Source: Deutsche Bank

 

Source: Deutsche Bank, Company data

 

 

 

 

 

 

 

AG/London

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

2018 December 10 Pharmaceuticals Pharmaceuticals European

vk.com/id446425943

Bank Deutsche

MorphoSys (Upgrading to Buy, PT €130)

 

MORe to come

AG/London

 

market (Tremfya, partnered with J&J) looks poised to become a multi-billion blockbuster and we believe that late stage data for its proprietary lead

 

We are upgrading to Buy as we believe the pipeline can continue to produce positive surprises. With 115 antibody drug candidates currently in

 

 

development (103 partnered, 12 proprietary) we see best-in-class risk diversification and value creation potential. The company’s first product on the

 

 

candidate MOR208 are very encouraging. In addition, we see multiple potential catalysts across the remainder of the portfolio, including a potential

 

 

near-term settlement of the MOR202 patent case. Shares are currently trading around 20% below all-time highs, while prospects look stronger than

 

 

ever before; Buy.

 

Tremfya taking up strongly, MOR208 data very encouraging, and further catalysts ahead. 2018 revenue guidance has been recently raised to the

 

 

higher end of the corridor (€67-72m) given strong uptake of Tremfya and corresponding royalty income, while the upcoming ECLIPSE read-out could

 

 

result in further upside to peak sales estimates. Meanwhile, the latest L-MIND data for MOR208 (esp. median progression free survival of 16.2 months)

 

 

look highly encouraging, suggesting scope not only for a successful launch in 2L DLBCL in 2020 as planned, but also for broadening of development

 

 

in 1L DLBCL. Other potential catalysts include settlement of the MOR202 patent case, PIII start for MOR103, PI/II data and further broadening of

 

 

development of MOR106, and up to 20 PII and III read-outs from the partnered pipeline to the end of next year.

 

Raising target price to €130 (€120). We have raised our DCF-derived target price, mainly on increased confidence in MOR208 and inclusion of a

 

 

potential settlement of the MOR202 patent case on conservative assumptions (please see overleaf for further details). Our earnings forecasts remain

 

 

broadly unchanged, but we see upside to our forecasts and target price on further pipeline de-risking. The main downside risks to relate to setbacks

 

 

regarding Tremfya, clinical MOR, and late-stage partnered programs as well as proprietary pipeline overspend and value-dilutive M&A and/or in-

 

 

licensing.

Figure 98 : MorphoSys valuation overview (EUR/share)

 

 

Figure 99 : MorphoSys NPV valuation

 

 

 

 

140

 

 

 

 

 

Product

Phase

Launch

Peak sales

Probability

NPV

NPV/share

% of total

 

 

 

 

 

 

 

 

 

(EURm)

 

(EURm)

(EUR)

 

120

 

 

 

0.1

11.3

 

 

 

 

 

 

 

 

 

 

6.7

 

Partnered programs

 

 

 

 

1,924

60.5

47%

 

 

 

 

 

 

 

 

 

 

 

 

 

Novartis (n=54)

pre PIII

pre 2026

48,000

11-33%

666

21.0

16%

 

 

 

15.2

 

 

100

 

Tremfya

 

 

Other (n=47)

pre PIII

pre 2026

42,000

11-33%

642

20.2

16%

 

 

 

 

 

 

 

5.9

 

 

Gantenerumab

III

2024

10,000

10%

135

4.2

3%

 

Gantenerumab

 

2.5

 

 

Tremfya

marketed

2017

3,000

100%

480

15.1

12%

 

 

 

 

 

80

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

MOR porgrams

 

 

 

 

 

58.3

45%

 

 

27.8

 

 

 

 

 

 

 

 

 

 

 

 

 

MOR208

III

2020

2,000

52%

884

27.8

21%

 

 

 

 

 

130.0

60

 

 

 

 

MOR202

II

2022

500

33%

80

2.5

2%

 

 

 

 

 

 

 

 

 

 

 

marketed

2015

 

25%

 

 

 

 

 

15.1

 

 

 

Darzalex royalties

7,000

188

5.9

5%

 

4.2

 

 

 

 

MOR103

II

2023

1,500

65%

485

15.2

12%

40

 

 

 

 

MOR106

II

2024

2,000

30%

213

6.7

5%

 

 

 

 

 

 

20.2

Other collaborations

 

 

 

other (n=7)

pre PII

tbd

tbd

tbd

3.2

0.1

0%

 

 

 

 

 

Net cash

 

 

 

 

358

11.3

9%

20

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

130.0

100%

 

21.0

Novartis collaboration

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

0

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Partnered Partnered Partnered MOR208 MOR202

Darzalex

MOR103 MOR106 other MOR Net cash

Total

 

programs

programs

programs

royalties

programs

(DB target

55Page

(pre PIII)

(PIII)

(marketed)

 

 

price)

Source: Deutsche Bank

 

 

 

 

Source: Deutsche Bank

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

2018 December 10 Pharmaceuticals Pharmaceuticals European

vk.com/id446425943

56 Page

 

Support for change in recommendation

 

 

 

 

MOR208 profile looks compelling and opportunity could go far beyond 2L DLBCL. MorphoSys’ proprietary lead candidate MOR208 (Fc-enhanced

 

 

 

 

 

anti-CD19 antibody) is developed in various blood cancers (DLBCL, CLL, SLL). The compound received FDA Breakthrough Therapy designation

 

 

 

in Oct-17, based on strong interim data in combination with lenalidomide for treatment of patients with 2L DLBCL. The latest update from the

 

 

 

corresponding L-MIND trial has further added to the profile of the compound with an impressive mPFS of 16.2 months among the highlights. This

 

 

 

compares very favorably to existing/upcoming approaches (3-11 months mPFS) and strongly supports plans for a US launch in 2020. Based on the

 

 

 

data, we have increased our fair value of MOR208 to E28/share (E21 prev.), assuming higher peak sales (E600m vs. E500m prev.) and probability of

 

 

 

success (80% vs. 70% prev.) in 2L DLBCL. We have left assumptions for other indications unchanged (E1.5bn peak sales, 33% probability of success),

 

 

 

but note that these could prove very conservative. Accordingly, we look forward to further updates including the planned broadening of development

 

 

 

into 1L DLBCL (alone or together with a partner) and a commercial partnership ex the US (where MorphoSys plans to market the product on its own).

 

 

Tremfya taking up strongly and peak sales estimates could rise further. In 2017, Tremfya, marketed by J&J for plaque psoriasis, became the first

 

 

 

drug based on MorphoSys’ antibody technology to receive regulatory approval and since then has taken up strongly with c.€150m sales in 3Q18. We

 

 

 

have left our €3bn peak sales estimate unchanged for now, but see further upside based on J&J’s strong commercial e orts and further development

 

 

 

including ongoing PIII studies psoriatic arthritis and Crohn’s disease. Indeed, we believe current market share in psoriasis already support about 2/3

 

 

 

of our peak sales estimate, while further share gains are likely and could be accelerated based on the upcoming ECLIPSE read out comparing Tremfya

 

 

 

and Cosentyx (consensus peak sales ~€5bn). Similarly, psoriatic arthritis and Crohn’s could roughly double the market opportunity for Tremfya with

 

 

 

first read-outs possible late next year and every €1bn in peak sales worth about €2/share.

 

 

MOR202 patent litigation could drive meaningful upside. MorphoSys has filed a lawsuit against J&J and Genmab for infringement of several patents

 

 

 

by Darzalex (launched in 2015, consensus peak sales ~€6bn). The jury trial is scheduled for 2019 and while the outcome is di cult to predict, we

 

 

 

wouldn’t be surprised if the parties settle before. We have decided to include this possibility in our valuation, conservatively assuming a 25% probability

 

 

 

and 2.5% royalty rate on Darzalex sales, which adds €6/share to our model. At the same time we have reduced the fair value of MOR202 to €2/share

 

 

 

(from €5) to reflect the company’s decision to no longer invest behind it in multiple myeloma without a partner; i.e. we only carry a value for the

 

 

 

partnership with iMAB in Greater China with upside from further partnerships and/or development in other indications such as autoimmune diseases.

 

 

 

 

 

 

 

 

Figure 100 : Potential news flow

 

 

 

 

 

Timing

 

Event / Description

Timing

Event / Description

 

 

 

 

 

 

 

Corporate / Selected proprietary programs

Selected partnered programs

 

 

early Dec 2018

MOR208 L-MIND data presentation at Ash and update on further development plans

early 2019

Tremfya - PIII ECLIPSE read-out (vs. Cosentyx in moderate/severe plaque-type psoriasis)

 

 

1Q-19

 

MOR202 start of pivotal study in multiple myeloma in China partner by I-MAB

2H-19

Tremfya - PIII Discover-1 read-out (psoriatic arthritis)

 

 

1Q-19

 

MOR202 patent case update (jury trial or potential settlement before)

2H-19

Utomilumab - PII read-out in oropharyngeal cancer

 

 

13-Mar-19

 

4Q18 results (after US market close)

2H-19

Setrusumab - PII data in osteogenis imperfecta

Deutsche

 

07-May-19

 

1Q19 results (after US market close)

2019

Gantenerumab - PIII data in mild Alzehimer's (open labe extension)

 

1H-19

 

MOR103 update on further development plan by partner GSK (i.e. pot'l start of PIII)

2019

Anetumab ravtansine - various PII read-outs in mesothelin expressing cancers

 

1H-19

 

MOR202 update on development plans in autoimmune diseases

2019

Bimagrumab - various PII read-outs across Sarcopenia, muscular artrophy, diabetes mellitus

 

mid-2019

 

MOR208 final L-MIND data and subsequent filing with the FDA

2019

Ianalumab - PII read-outs in Pemphigus Vulgaris and Primary Sjörgen's syndrome

Bank

 

06-Aug-19

 

2Q19 results (after US market close)

 

 

 

 

29-Oct-19

 

3Q19 results (after US market close)

 

 

 

AG/London

 

2H-19

 

MOR106 PII data from IGUANA trial

 

 

 

2019

 

MOR208 potential partnering (e.g. Europe commercilization, development beyond 1L DLBCL)

 

 

 

 

Source: Deutsche Bank, Company data

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

2018 December 10 Pharmaceuticals Pharmaceuticals European

vk.com/id446425943

Deutsche

 

Summary model

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Figure 101 : MorphoSys summary P&L

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Bank

 

EURm ex-per share data

 

 

 

2013A

2014A

 

2015A

 

2016A

 

 

2017A

 

2018E

 

2019E

 

 

 

2020E

 

2021E

2022E

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

AG/London

 

Revenue

 

 

 

 

 

 

 

 

78

 

64

 

106

 

50

67

 

71

 

37

 

 

 

85

 

161

248

 

Gross margin

 

 

 

 

 

 

100%

 

100%

 

100%

 

100%

100%

 

100%

 

100%

 

 

 

94%

 

94%

92%

 

 

Growth

 

 

 

 

 

 

 

 

 

 

-18%

 

66%

 

-53%

34%

 

6%

 

-48%

 

 

 

130%

 

91%

53%

 

 

Gross profit

 

 

 

 

 

 

 

 

78

 

64

 

106

 

50

67

 

71

 

37

 

 

 

80

 

151

228

 

 

SG&A

 

 

 

 

 

 

 

 

19

 

14

 

15

 

14

17

 

30

 

43

 

 

 

60

 

 

69

71

 

 

R&D

 

 

 

 

 

 

 

 

49

 

56

 

79

 

96

117

 

101

 

101

 

 

 

101

 

102

102

 

 

EBIT

 

 

 

 

 

 

 

 

10

 

-6

 

17

 

-60

-68

 

-60

 

-107

 

 

 

-82

 

-19

54

 

 

EBIT margin

 

 

 

 

 

 

13%

 

-9%

 

16%

 

-121%

-101%

 

-85%

 

-291%

 

 

 

-96%

 

-12%

22%

 

 

Financial result

 

 

 

 

 

1

 

2

 

3

 

0

-1

 

-1

 

0

 

 

 

0

 

 

0

0

 

 

Income tax

 

 

 

 

 

 

 

 

3

 

-1

 

6

 

1

1

 

0

 

0

 

 

 

0

 

 

0

0

 

 

Tax rate

 

 

 

 

 

 

31%

 

30%

 

28%

 

-1%

-2%

 

0%

 

0%

 

 

 

0%

 

0%

0%

 

 

Net income

 

 

 

 

 

 

 

 

13

 

-3

 

15

 

-60

-70

 

-61

 

-107

 

 

 

-82

 

-19

54

 

 

EPS

 

 

 

 

 

 

0.54

 

-0.12

 

0.57

 

-2.28

-2.41

 

-1.99

 

-3.37

 

 

 

-2.56

 

-0.60

1.71

 

 

Growth

 

 

 

 

 

 

 

 

 

-123%

 

-595%

 

-505%

16%

 

-12%

 

69%

 

 

 

-24%

 

-77%

-384%

 

 

Source: Deutsche Bank, Company data

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Figure 102 : Maturing pipeline (# of programs)

 

 

 

 

 

 

Figure 103 : Revenues by segment (EURm)

 

 

 

 

 

 

100

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

250

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

90

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

200

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

80

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

70

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

150

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

60

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

50

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

100

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

40

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

30

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

50

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

20

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

10

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

0

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

0

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

2012A

2013A

2014A

2015A

2016A

2017A

2018E

2019E

2020E

2021E

2022E

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

2006

2007

2008

2009

2010

2011

2012

2013

2014

2015

2016

2017

2018

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Pre-clinical programs

 

Clinical programs

 

 

Marketed programs

 

 

 

 

 

 

 

 

 

 

Partnered discovery

 

 

Proprietary development

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Source: Company data

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Source: Deutsche Bank Company data

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

57 Page

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

2018 December 10 Pharmaceuticals Pharmaceuticals European

10 December 2018

Pharmaceuticals

European Pharmaceuticals

vk.com/id446425943

Page 58

Deutsche Bank AG/London

vk.com/id446425943

Bank Deutsche

Evotec (Buy, PT €22)

 

Still in strong operational shape - further catalysts expected in 2019

AG/London

 

partnered compounds continues to mature and carries the potential for significant value creation. With the shares trading at 54x P/E and 29x EV/

 

We believe that growth trends for Evotec’s business are fully intact. The drug discovery and development services business continues to benefit

 

 

from a strong outsourcing and consolidation trend, and it should grow 10-15% organically in 2019 and beyond. Furthermore, the pipeline of c.100

 

 

EBITDA (all 2019) against expected 2017-25E sales and EBITDA CAGRs of 15% and further catalysts expected in 2019 (such as additional partnerships

 

 

and milestones), we see upside to current share price levels.

 

The pipeline of 100 partnered compounds is currently not fully priced in. Our SOTP valuation yields a fair value of €14 for the ‘’EVT Execute’’ services

 

 

business, which means that at current share price levels, the “EVT Innovate” pipeline is not fully priced in, even though it carries a value of €8, on

 

 

our estimates. We expect meaningful milestone payments for the pipeline again in 2019 and more compounds should enter into the clinical studies.

 

 

There is also the potential for additional pipeline partnerships in 2019.

 

Evotec is an innovation leader. We expect the company to continue to focus on innovation in 2019. Evotec’s induced pluripotent stem cell (IPSC)

 

 

platform is unique and aims to perform early-stage drug screening in human derived cell at an earlier point, thereby improving the predictability of

 

 

a drug’s potential success. It also aims to develop novel therapies. The platform is already partnered with Celgene (in neurodegenerative diseases)

 

 

and Sanofi (diabetes), and additional partnerships are likely (potentially already in 2019). Also, Evotec took an equity stake in Exscientia in 2017, a

 

 

UK company that applies artificial intelligence to early stage drug screening. We believe that Evotec should continue to outgrow the competition in

 

 

2019 due to it's innovative and industry leading platforms.

Figure 104 : Revenue and adj. EBITDA margin development

 

Figure 105 : Newsflow

 

900

 

 

 

 

 

 

 

 

 

50.0%

Timing

Type

Description

800

 

 

 

 

 

 

 

 

 

45.0%

28-Mar-19

Results

FY 2018

 

 

 

 

 

 

 

 

 

 

 

 

700

 

 

 

 

 

 

 

 

 

40.0%

14-May-19

Results

Q1 2019

 

 

 

 

 

 

 

 

 

 

 

 

 

600

 

 

 

 

 

 

 

 

 

35.0%

19-Jun-19

AGM

Annual General Meeting

 

 

 

 

 

 

 

 

 

 

13-Aug-19

Results

Q2 2019

500

 

 

 

 

 

 

 

 

 

30.0%

 

 

 

 

 

 

 

 

 

 

12-Nov-19

Results

Q3 2019

 

 

 

 

 

 

 

 

 

 

25.0%

 

 

 

 

 

 

 

 

 

 

 

 

 

400

 

 

 

 

 

 

 

 

 

20.0%

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

300

 

 

 

 

 

 

 

 

 

15.0%

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

200

 

 

 

 

 

 

 

 

 

10.0%

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

100

 

 

 

 

 

 

 

 

 

5.0%

 

 

 

0

 

 

 

 

 

 

 

 

 

0.0%

 

 

 

2015A

2016A

2017A

2018E

2019E

2020E

2021E

2022E

2023E

2024E

2025E

 

 

 

 

 

Revenue (lhs, EURm)

 

 

 

Adj. EBITDA margin (rhs, %)

Source: Deutsche Bank, Company data

 

 

 

 

Source: Deutsche Bank, Company data

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

59 Page

2018 December 10 Pharmaceuticals Pharmaceuticals European

vk.com/id446425943

Page

 

 

 

 

 

 

 

 

 

 

 

 

Figure 106 : Evotec summary P&L

 

 

 

 

 

 

 

 

 

 

 

60

 

2015A

2016A

2017A

2018E

2019E

2020E

2021E

2022E

2023E

2024E

2025E

 

Revenue

127.7

164.5

257.6

366.1

412.7

465.2

491.5

554.3

625.2

705.1

795.3

 

Milestones/upfronts/licenses

12.3

18.9

27.8

 

 

 

 

 

 

 

 

 

Gross profit

35.1

58.6

82.6

111.1

127.4

151.0

163.9

188.7

217.2

250.2

288.3

 

margin

28%

36%

32%

30%

31%

32%

33%

34%

35%

35%

36%

 

Total operating costs

23.5

27.2

45.1

28.9

59.1

72.2

101.8

112.7

128.1

147.1

167.5

 

Adj. EBITDA

8.7

36.2

58.0

83.7

99.2

111.3

94.1

109.2

126.7

145.4

168.5

 

margin

7%

22%

23%

23%

24%

24%

19%

20%

20%

21%

21%

 

EBIT

11.6

31.3

37.5

66.8

68.3

78.8

62.2

76.0

89.2

103.1

120.8

 

Non-operating income (expense)

0.9

1.6

-11.2

-2.3

-0.7

-0.2

0.4

0.8

1.3

1.9

2.6

 

EBT

12.5

33.0

26.3

64.5

67.6

78.6

62.5

76.8

90.5

105.0

123.3

 

Tax

4.0

-6.1

-2.3

-6.5

-15.2

-19.6

-15.6

-19.2

-22.6

-26.3

-30.8

 

Net profit

16.5

27.5

24.3

58.1

52.4

58.9

46.9

57.6

67.8

78.8

92.5

 

EPS

0.12

0.20

0.17

0.39

0.36

0.40

0.32

0.39

0.46

0.53

0.63

 

Source: Deutsche Bank, Company data

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Figure 107 : DBe 2019 revenue breakdown

 

Figure 108 : Sales and EPS 2015-2025E

 

 

 

 

 

EVT INNOVATE

 

900

 

 

 

 

 

 

 

 

 

0.80

15%

 

800

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

0.70

 

 

 

 

 

 

 

 

 

 

 

 

 

 

700

 

 

 

 

 

 

 

 

 

0.60

 

 

 

 

 

 

 

 

 

 

 

 

 

 

600

 

 

 

 

 

 

 

 

 

0.50

 

 

 

 

 

 

 

 

 

 

 

 

 

 

500

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

0.40

 

 

400

 

 

 

 

 

 

 

 

 

 

 

 

300

 

 

 

 

 

 

 

 

 

0.30

 

 

 

 

 

 

 

 

 

 

 

 

 

 

200

 

 

 

 

 

 

 

 

 

0.20

 

 

 

 

 

 

 

 

 

 

 

 

 

 

100

 

 

 

 

 

 

 

 

 

0.10

 

 

 

 

 

 

 

 

 

 

 

 

 

EVT EXECUTE

0

 

 

 

 

 

 

 

 

 

0.00

 

2015A

2016A

2017A

2018E

2019E

2020E

2021E

2022E

2023E

2024E

2025E

 

85%

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

REVENUE (LHS, EURM)

 

 

EPS (RHS, EUR, DILUTED)

 

Source: Deutsche Bank, Company data

 

Source: Deutsche Bank, Company data

 

 

 

 

 

 

 

 

AG/London Bank Deutsche

2018 December 10 Pharmaceuticals Pharmaceuticals European