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REGIMENS FOR TAKING ANTI-TB

MEDICATIONS:

1.The optimal regimen for administering TB drugs is to administer the daily dose at a time.

2.In case of adverse reactions, the daily dose can be divided into 2 doses. In this situation, the intervals between doses should be minimal.

3.It is possible to use fractional administration of a daily dose of the drug or intermittent (intermittent) administration of a full dose (3 times a week), it is possible to increase the interval between doses of different drugs, to change the way of administration of the drug.

WAYS OF ADMINISTERING

ANTITUBERCULOSIS DRUGS:

1.Intravenously.

2.Intramuscular.

3.Intravenous (by drip or stream).

4.Endobronchial infusions.Inhalation of aerosols.

5.Rectal administration (enemas, suppositories).

CLASSIFICATION OF ANTI-TB DRUGS (WORLD HEALTH ORGANIZATION, 1998):

1ST LINE DRUGS (CORE):

Isoniazid (H)

Rifampicin (R)

Pyrazinamide (Z)

Etambutol (E)

Streptomycin (S)

2ND LINE DRUGS (RESERVE DRUGS):

Kanamycin (amikacin) (K)

Ethionamide (prothionamide) (Et, Pt)

Cycloserine (Cs)

Capreomycin (Cap) Aminosalicylic acid Fluoroquinolones (Fg)

3RD LINE DRUGS:

Clarithromycin Amoxicillin + clavulanic acid

Clofazimine

Linezolid

Combination antituberculosis drugs are two-, three-, four- and five-component drug forms with fixed doses of individual substances.

They are used both in acute process and in the phase of treatment.

CHEMOTHERAPY REGIME

selection of the optimal combination of drugs, their doses, routes of administration, rhythm of administration, and duration of treatment.

The chemotherapy regimen is determined taking into account:

character of regional drug sensitivity of MBT to antituberculosis drugs;

epidemiological hazard (contagiousness) of the patient;

nature of the disease (newly detected case, relapse, chronic course);

the prevalence and severity of the process;

drug resistance of MBT;

the dynamics of clinical and functional indicators;

dynamics of bacteriological excretion;

involution of local forms in lungs (resorption of infiltration and closure of caverns).

TYPES OF CHEMOTHERAPY REGIMENS:

Standard - is carried out by a combination of the most effective drugs. This choice is conditioned by the fact that determination of MBT drug sensitivity takes 2.5-3 months.

Individual regimen is prescribed after receiving information about sensitivity of the pathogen, i.e. the therapy is adjusted.

I STANDARD CHEMOTHERAPY

REGIMEN

INTENSIVE PHASE OF

CONTINUATION OF

 

THERAPY PHASE

 

THERAPY

 

 

 

 

HR or H3R3

 

 

 

 

 

 

 

 

HRZE or HRZS

 

 

 

(4 month);

 

(2 month)

 

 

 

 

 

HE (6 month)

 

 

 

 

 

 

IIa STANDARD chemotherapy regimen

INTENSIVE PHASE OF

 

CONTINUATION OF

 

 

 

THERAPY PHASE

 

THERAPY

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

HRZES (2 month);

HRE or H3R3E3

 

 

HRZE (1 month)

 

 

 

(5 month)

 

 

 

 

 

 

 

 

 

 

 

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