- •1.1. Overview
- •1.7. For information about the teachers:
- •1.8. Contact Information:
- •2. Program:
- •2.1. Introduction
- •2.2. The purpose of discipline:
- •2.3. Learning objectives:
- •2.4. Learning outcomes:
- •2.5.Prerequisites and Postdetails.
- •2.6. Summary of discipline:
- •2.7. Thematic plan of lectures, practical classes, srps and the siw Thematic plan of lectures
- •The practical classes thematic plan
- •Topical Plan for siwp
- •Thematic plan for independent student work
- •2.8. Tasks for independent students work : Topics for independent work of students:
- •2.9 Recommended literature :
- •In Russian :
- •In Kazakh:
- •In English :
- •2.11. Criteria and assessment rules:
- •The evaluation system of students' knowledge
- •Competence assessment in discipline "Molecular Biology and Medical Genetics," for 1 course students "General Medicine" specialty.
- •2.Check control
- •Presentation
- •Assessments grading scale
- •It is discussed and approved at faculty meeting from April "12" of 2012 y., the protocol No. 15
- •1. Theme: Implementation of heriditary information
- •3. Theses of lectures:
- •5. Literature:
- •6. Control questions (feedback):
- •3. Theses of lectures:
- •5. Literature:
- •6. Control questions (feedback):
- •3. Theses of lectures:
- •5. Literature:
- •6. Control questions (feedback):
- •3. Theses of lectures:
- •5. Literature:
- •6. Control questions (feedback):
- •3. Theses of lectures:
- •5. Literature:
- •6. Control questions (feedback):
- •3. Theses of lectures:
- •5. Literature
- •6. Control questions (feedback):
- •Specialty – general medicine
- •Year 2012
- •Theme: Introduction to Molecular Biology. Molecular Principles of Heredity
- •Educational Tasks:
- •Principal Questions of the Theme:
- •Literature:
- •Control:
- •Evaluation of competence – knowledge
- •Theme: Gene Molecular Biology
- •Educational Tasks:
- •Principal Questions of the Theme:
- •Literature:
- •Control:
- •Evaluation of competence – knowledge
- •Evaluation of competence – practical skills
- •Theme: Realization of Hereditary Information. Dna Replication
- •Educational Tasks:
- •Principal Questions of the Theme:
- •Literature:
- •Control:
- •Evaluation of competence – knowledge
- •Problem
- •Theme: Transcription
- •Educational Tasks:
- •Principal Questions of the Theme:
- •Literature:
- •Control:
- •Evaluation of competence – knowledge
- •Literature:
- •Control:
- •7.1. Evaluation of competence – knowledge
- •Theme: Regulation of Gene Expression
- •Educational Tasks:
- •Principal Questions of the Theme:
- •Literature:
- •Control:
- •7.1. Evaluation of competence – knowledge
- •Evaluation of competence – practical skills
- •8.1.Control:
- •8.2. Rating of competence skills.
- •Theme: Genetic Apparatus of the Cell
- •Educational Tasks:
- •Principal Questions of the Theme:
- •Literature:
- •Control:
- •7.1. Evaluation of competence – knowledge
- •7.2. Evaluation of competence – practical skills
- •Theme: Mitotic cycle, Mitosis, Meiosis
- •Educational Tasks:
- •Principal Questions of the Theme:
- •Literature:
- •Control:
- •Evaluation of competence – knowledge
- •Evaluation of competence – practical skills
- •7.2.6. Solution of standard tasks:
- •1. Theme: Heredity. Types of inheritance. Independent monogenic inheritance of characteristics
- •2. Purpose:
- •3. Learning objectives:
- •4. Key questions the theme:
- •6. Literature
- •7. Control:
- •7.1. Assessment of cognitive competences (knowledge):
- •7.2. Assessment of competence skills
- •7.3. Assessment of the skills of self-improvement:
- •1.Theme: Heredity. Types of inheritance. Monogenic traits linked inheritance
- •2. Purpose:
- •3. Learning objectives:
- •4. Key questions the theme:
- •7.1. Assessment of cognitive competences (knowledge):
- •1. Theme: Effects of gene
- •2. Purpose:
- •3. Learning objectives:
- •4. Key questions the theme:
- •6. Literature
- •7. Control:
- •7.1. Assessment of cognitive competences (knowledge)
- •7.2. Assessment of competence skills
- •1. Theme: Cellular mechanisms of ontogenetic development
- •2. Purpose:
- •3.Learning objectives:
- •4. Key questions the theme:
- •6. Literature:
- •7. Control:
- •7.1. Assessment of cognitive competence - knowledge
- •1.Theme: Genetic mechanisms of ontogenetic development
- •2. Purpose:
- •3. Learning objectives:
- •4. Key questions the theme:
- •6. Literature:
- •7. Control:
- •7.1. Assessment of cognitive competence - knowledge
- •7.2. Assessment of competence skills
- •1. Title: Basics of Genetics populyatsioinoy
- •6. Handout: Test questions. 7. Literature:
- •1.Theme: Fundamentals of Ecological Genetics
- •4. Key questions the theme:
- •6. Литература:
- •7. Control:
- •7.1. Assessment of competencies - knowledge.
- •Some environmental disease caused by
- •Air pollution
- •Contamination of drinking water
- •Intestinal infections
- •7.1.6. The decision of situational problems:
- •7.2. Assessment of competence - legal competence.
- •Theme: Fundamentals of Pharmacogenetics
- •Educational Tasks:
- •Principal Questions of the Theme:
- •Literature:
- •Control:
- •Evaluation of competence – knowledge
- •Evaluation of competence – practical skills
- •4.Osnovnye topic questions:
- •Specialty-general medicine methodology recommendation for independent work teacher-led
- •8. Control:
- •8.1.3. Filling out tables:escribe the types of apoptosis
- •1. Theme: Variability not hereditary and hereditary.
- •3. Problems of training:
- •4. Main questions of a subject:
- •6. Literature:
- •7. Control:
- •7.1. An assessment of competences – knowledge.
- •7.2. An assessment of competences – legal competence.
- •3. Problems of training:
- •4. Main questions of a subject:
- •6. Literature:
- •7. Control:
- •7.1. An assessment of competences – knowledge.
- •3.Learning objectives:
- •5.Key questions the theme:
- •7. References:
- •8. Control:
- •3.Learning objectives:
- •5.Tasks related to:
- •6.Handout material: test-2 version with 10 questions
- •7.References:
- •7.3.Konichev a .S. Sevyastanova g.A. Molecular biology m. 2005 p.N 150-196.351-379.
- •7.4.Teylor d.Grin. N.Staut u.Biology m.2002 part 3 p.N 215-242.
- •8. Control:
- •8.1.1 Quiz on topics.
- •8.1.5.The solution to the problem of restriction of dna.
- •8.1.6. Working with the human genomic databases: problem solving.
- •8.3. Control:
- •1 . Title: Control of landmark forum: "Molecular Biology of the Cell"
- •7. References: The main
- •Theme: Human Hereditary Diseases. Chromosomal Diseases
- •Object:
- •Educational Tasks:
- •Principal Questions of the Theme:
- •Literature:
- •Control:
- •Evaluation of competence – knowledge
- •Impairment related to different types of human aneuploidy
- •Evaluation of competence – practical skills
- •Theme: Human Hereditary Diseases. MonogenicMendelian Diseases
- •Object:
- •Educational Tasks:
- •Principal Questions of the Theme:
- •Literature:
- •Control:
- •Evaluation of competence – knowledge
- •Evaluation of competence –communicative skills
- •Solution of situational problems
- •Title: Monogenic nonmendelian human disease
- •Aims: To generate in students the knowledge of nonmendelian monogenic human disease.
- •Learning objectives:
- •Tasks related to:
- •Handout material: test-2 version with 10 questions
- •References:
- •Control:
- •Theme: Polygenic (Multifactor) Human Diseases
- •Educational Tasks:
- •Principal Questions of the Theme:
- •Literature:
- •Control:
- •Evaluation of competence – knowledge
- •Principal Questions of the Theme:
- •Literature:
- •Control:
- •Evaluation of competence – knowledge
- •Collection of anamnesis (determine the data that permit to reveal families with increased risk of birth of a child with hereditary pathology)
- •In case of chromosomal diseases In case of genic diseases
- •Title: Modern methods of prevention and treatment genetic diseases
- •Key questions the theme:
- •6. Handout: test questions.
- •7. References:
- •8.Control:
- •8.5.An algorithm preventing hereditary diseases, to determine the indications
- •6. Handout: test questions.
- •7. References:
- •8. Control:
- •1.Theme: Section control on the section "Basis of medical genetics"
- •3.Tasks of teaching:
- •7. References:
- •8. Control:
- •8.2. Rating of competence skills.
- •Title: Monogenic nonmendelian human disease
- •Learning objectives:
- •Tasks related to:
- •Handout material: test-2 version with 10 questions
- •References:
- •Control:
- •6. Handout: test questions.
- •7. References:
- •6. Handout: tests
- •7.Bibliography:
- •8. Control:
- •Title: Modern methods of prevention and treatment genetic diseases
- •Key questions the theme:
- •7. References:
- •8.Control:
- •8.5.An algorithm preventing hereditary diseases, to determine the indications
- •3.Tasks of teaching:
- •5. The main themes:
- •7. References:
- •8. Control:
- •8.2. Rating of competence skills.
- •1. Theme #1. Telomers. Telomerase activity
- •3. The tasks:
- •5. Performance criteria:
- •5. Performance criteria:
- •8. Bibliography:
- •8. Bibliography:
- •9. Check:
- •1. Theme #5. Genomics, proteomics and metabolonomics
- •3. The tasks:
- •5. Performance criteria:
- •8. Bibliography:
- •9. Check:
- •1. Theme #6. Cloning of organisms and cells
- •3. The tasks:
- •5. Performance criteria:
- •8. Bibliography:
- •8. Bibliography:
- •9. Check:
- •1. Theme #9. Molecular and genetic mechanisms of aging
- •3. The tasks:
- •5. Requirements to presentation making up:
- •8. Bibliography:
- •8. Bibliography:
- •8. Bibliography:
- •9. Check:
- •1. Theme #13. Human genetic passport
- •3. The tasks:
- •5. Requirements to abstract work design:
- •8. Bibliography:
- •8. Bibliography:
- •8. Bibliography:
- •8. Bibliography:
- •8. Bibliography:
- •8. Bibliography:
- •9. Check:
- •Control and measuring means for the assessment of knowledge, skills in molecular biology and medical genetics
- •2012 Year
- •I. Examination questions:
- •II. The test exam questions:
- •Molecular biology
- •Replication
- •II. Molecular Cell Biology
- •Cell Cycle
- •Ontogenezis
- •Mutations
- •Oncogenetics
- •III. Fundamentals of general genetics
- •Ekogenetic
- •Pharmacogenetics
- •IV. Fundamentals of medical genetics
- •The list of questions to assess the practical skills: Molecular biology
- •Genetics
8.3. Control:
8.3.1.What is a gene?
8.3.2. The value of the "human genome" in medicine
8.3.3. List the methods of DNA analysis
8.3.4. How to use the genomic databases of man?
Lesson number 5
1 . Title: Control of landmark forum: "Molecular Biology of the Cell"
2. Aims: To determine the level of learning and understanding the students the material of lectures and practical sessions on the structure and functioning of the genetic material of cells, causes and mechanisms of mutation, the molecular mechanisms of DNA repair. the role of genetics of oncology
3. Learning objectives: through oral questioning, testing, and typical problems to determine the level of assimilation and understanding of students in this section.
4. Form of Locations: quizzes aimed na asking students understand the nature of goals and objectives of the training, skills, briefly, clearly and logically set out. and the ability to 'represent the digested material in the form of diagrams. graphs, drawings, testing and subsequent analysis of errors in the work group: an explanation and demonstration of problem solving, filling schemes.
5.Tasks related to: 5.1. Localization of the genetic material in the cell (nuclear, cytoplasm! The algebraic). 5.2. Levels of structural and functional organization of the genetic material of cells and mechanisms of their formation. 5.3. Nukleogistonnes organization of genetic material. 5.4. The chemical composition of chromosomes. Chromatin, the one-and heterochromatin. characteristic. 5.5. 'Gily chromosomes. Denver and the Paris nomenclature of chromosomes. 5.6. Karyotype determination, medical and genetic significance. 5.7 Cell cycle, the definition of the periods. 5.8. Mitoticheeky cycle definition, period. 5.9. Mitosis, characteristic. 5.10. Gametogenesis. Ootepez, spermatogenesis. 5.11. Msyoz. characteristic. 5.12. General biological. genetic and medical importance of cell division. 5.1.1. The mechanisms of genetic regulation mitotic cycle. 5.14. Mechanisms of genetic control mitoticheeshgo cycle. 5.15. The causes and mechanisms of disorders migoticheskogo cycle. 5.16. Medical consequences of violations mitoticheekoto cycle. 5.17. Genetic variation 5.18. Rekombinativpaya variability 5.19. Mutagenesis, mutagenic factors. 5.20. Mutational variability of the classification 5.21. Genomic and chromosomal mutations, their role is the development of chromosomal diseases. 5.22. The Law of 1'K 23.04,1998 N 219 - ["On radiation safety of population" 5.23. Code of 09.01.2007 N 2 12 - 111 "Environmental Code" (Chapter 40) 5.24. Chromosomal mutation, causes, classification. 5.25. Chromosomal mutations, the mechanisms of occurrence. 5.26. Gene mutation, causes, classification. 5.27. Mutations in type) replication errors, mechanisms, and development. 5.28. Mutations in the type of shift the reading frame, the mechanisms of development. 5.29. Mechanisms of development of hereditary diseases in different types of hereditary diseases. 5.30. Repair, types and mechanisms of repair: - photo reactivation
- Excision repair; - Postreplikativnaya repair; - Miss - Match repair; - 308 - reparation. 5.31. Antimutatsionnye barriers. 5.32. Biological and medical significance of DNA repair. 5.33. Apoptosis, a definition. 5.34. The causes apoptosis. 5.35. The stages of apoptosis. 5.36. Genetic control of apoptosis. 5.37. The medical significance of apoptosis. 5.38. Carcinogenic factors, classification, and their role in causing malignant transformation of cells. 5.39. Protonkogeny and oncogenes, the concept, role in the origin and development of malignant transformation of cells. 5.40. Oncoviruses, and their role in causing malignant transformation. 5.41. Malignant tumors, stage of development property. 5.42. Antionkogeny, the mechanisms of antitumor protection. 5.43. The value of genetics in modern oncology. 5.44. The structural organization of the human genome. Genomics and its direction. The "human genome" and its significance. 5.45. Genetic engineering technology, Recent advances in genetic engineering and its prospects. 5.46. The main stages of the molecular analysis of DNA. Molecular genetic methods: 1SCHR. restriction of DNA, blot gibrizidapii methods, DNA cloning. sequencing. 5.47. The main areas of application of modern molecular genetic techniques and technologies in medicine. 5.48. Isolation of DNA from the genome of a given gene. 5.49. The transfer of genes into cells of other organisms. 5.50.Transgennye plants. 5.51. DNA diagnostics. 5.52. Hematherapy hereditary diseases. 5.53. Gene and cell biotechnology: achievements and prospects. 5.54. Methods for creating traiegennyh organisms, vectors for gene transfer. 5.55. Biosecurity gsiomodifitsirovanpyh organisms (GMOs): problems and solutions. 5.56. The use of GMOs in medicine. 5.57. The structure of the eukaryotic genome. Mobile elements of the genome. 5.58. Genomics and its direction. \ 5.59. Proteomics - a new direction in biology and medicine of the XXI century. 5.60. Metabolite th ika and the development of new drugs. 5.61. Bioinformatics and its prospects.
6. Teaching methods: a combined method of teaching (conversation, solving typical problems)