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Поступила 5.12.2011

OXYGEN TENSION IN HUMAN SUBCUTANEOUS TISSUE

AS AN INFORMATIVE INDICATOR FOR CLINICAL

STUDIES OF OXYGEN UPTAKE IN TISSUES DURING

AGING AND FOR ASSESSMENT OF EFFICACY OF

GERIATRIC DRUGS

O. V. Korkushko, L. A. Ivanov

State Institution "D. F. Chebotarev Institute of Gerontology

NAMS Ukraine", 04114 Kyiv

The results of investigations showed the determination of oxygen tension in tissues (subcutaneous cellular tissue) by method of polarography using functional tests (inhalation of oxygen, crossclamping of vessels) to be an informative clinical approach to the study of intensity of tissue respiration. Considered were the factors, which determine development of tissue hypoxia in the elderly and old people. The decrease if intensity of tissue respiration with age was shown to be mainly related with the agerelated changes in the activity of enzymes of biological oxidation. Age-related decrease of tissue perfusion during aging resulted in the disturbance of oxygen supply and had a negative effect on the intensity of tissue respiration due to inhibition of enzymes of biological oxidation, being an additional factor of development of tissue hypoxia. The intake of vitamin complex "Geroton" by the elderly and old persons with accelerated aging led to the increase of intensity of tissue respiration, improvement general health status, increase of physical working capacity, expansion of the range of adaptive mechanisms of various organs and systems. The above findings substantiate the need for intake of vitamin complex for prevention and treatment of accelerated aging.

Сведения об авторах

Отдел клинической физиологии и патологии внутренних органов

О. В. Коркушко – руководитель отдела, акад. НАМН Украины

([e-mail])

Л. А. Иванов – д.м.н., профессор

ISSN 0869 1703. ПРОБЛ. СТАРЕНИЯ И ДОЛГОЛЕТИЯ. 2012. Т.21. № 1