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11
% 2
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13
2. & # & # $" % $% " ( '
* = + G" ' = : * , , * , -. ( . 3).
C * + = @ , - >@ , > G" * . ; * > * , = -, ; + .
% , = ; 50 */ * -> = > > -' > * + 48 . , * , -' > ; , QO =Q = * . K-, + . E G" , ' = * - > > ' * * . -M * * @ +* @ M + * -, Q >@ * + ( * =, ; *- =). + Q . " -' , = * = * @ =Q. " + > * , + 1–3- =.
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14
15
% 3
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16
' . 3
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* , = , > -> . ? > = - = , =. ? , - ' @ , = . +* * = + . D >- @ + * O* . - > * > . E > -> = * * * ( * ), -' > + > * ,@ = .
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17
3. $ % $% " (
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3.1.25-2 /2 6 0/ 27 20/0 (5-20/0) :2;-20
% (%%#) G"> - ' G" + + G"* , , . + * ' -, +, ' * + , , , , -( . 6). + * – , , , , * , * , - * . D + , = +G", > , ' * , . % -, = * , * * - ' G", > : =, == * ( ' < * ' +), * , * * * * + .
18
3.1.1. , , ,
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* + ( . 10, ) -
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. 10. B 0
( ) + ( ) # * + $
19
G" Q * * + ,Q . ; * = > Q , + , , , ,, ' @ – > (!CR), > . < =- > !CR ' = * 30…38 %, = * 18…23 %.
A ' . ] + , >@* ' @ - + , = = -G" + + + - => + .
C «Rohm Pharma» (& ) ; * ( . 4) –* -+ O ' ; . " -
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Eudragit L ' G" |
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: eudragit L100–55 eudragit L30-D-55 – 12-O + Q , eudragit L100 – * Q + Q . Eudragit S100
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20