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Eudragit S100 |
–H+ |
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Eudragit L100 |
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Q - |
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Eudragit L30-D-55 |
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L100-55 |
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Eudragit RS, |
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Eudragit RL |
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Eudragit E 30-D |
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? ' + 750 ME, 400 *, - => 'O = 30 *. + , ' @ + = * ' * ' . > Q-@ * * , . < '' + , + .
C @ < 3–8 ' ,Q . = 'O =, @ - + +, ' > Q . -, * , ' . [O = @ '-' = . " 'O>@ = ' * .
% ;-* E ' 100 *, -40 *. – , + Q * * * ( + ), @. % – '-
21
+ ' , @ + +, -' + '- * . % > + , - > > , > ; = +.
' >@ * + ' -(1959 *.). " * = @-> > > ( ), +G". ? ' = [ % = * + , - + ' =>. " > -. ? ' = , + * -G" * ' - ' G". " * = @ ,* =:
1. & = ( >@ * ): , -> – * > (&D R), * -> (&D ?R), * ; > (&DWR), , * – * , , =* O =, , . > +@O . , * . R – * > ,+ Bacillus macerans. w-, Z- x- , ' @ 6, 7, 8 * > >- @ + 0,6, 0,8 1 , ( * ) 6, 8, 10 Å. O @ ( =* O , , ) * = '-G" < ' >@ + . & = - > , ' > > -[ % Q > . * + ' => * =, >@ + =-G".
< &D R * > « >@ » ,' @ > , , > = -5-. % ' > > -' , + , '- @ , > > ' ' 2–3 , -= ' G".
22
% 5
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@ ; > > ,O G", = , =- Q = +. * , >@ -, -' ( ).
< * &D R « >@ » , '- @ =, >@ > * ( == , * , + - , + &D R), * – > = --5-. " >@ + * > * = &D R, * ' . « >@ »' G" ' , * * + , = = * , - >@ + * .
= *, ' @ * ,> ->@ > + .> + O = + @O * . K- > > . $O ' , -
23
. < * -@ , =. ' = Q- * + ( 6 ) * , ' + .' * -, . "* = > - : ; / Q 3 : 1 : 1.
2. & ( ) * > = , * = , Q ' , -,- * – ; * , , = . % , * >* , > -( ' ) G", > -Q + . * - ' ' + = , *
– * . ' >@ + ;O- - * .* + * O * , ' @- * > . 90 % - * Q .
3. * = > - , >@ + . ' -; > , > , , ; ,. " * = @' [ %, ; > = , * >- @ + > + >@ @ . ' G" * + , ; > . %- =-> + > , @ > -, + > O = . =' 8–10 O -+ =>. > -+ =.
> * + .> O , ; > . " ' ,* + < [ %. @ = >= > G". G" ' * + =>, *.
24
4. * (-) = > ' * : - - = + , = = , ; . W @ , , > '- =>, > 40 % > . G @' O . %[ % > * > -* * .
# = = = Q + -+ [ %. " [ % -* -, ' @ = ' - > , ; ; . = +* ' = = ,' = Q .
" * G" > , >- @ + ( * ). " = >@ * = @ : -941 – 60 %, ( = = @O * * , + >- , * ) – 36 %, ; -300 – 3 %, * – 1 %.
D = , >* , = + -* .
! – + * Z- . - ' = = + ( – = ) * >. * + = = + --2–8 , 0,25 . E* Q > -2%-* . " 10 - * @ 100 % + . * + -. $ 18…20 * > - +, Q 80 °# O . # '0,01 %, * – 40 % @ + .* + - * 24 .
K O * -2 O - + ; - . * =- > !"-16 *, !-16 * . A * - > O + => Q . + > @ + +, Q - + > > > (- , , ).
25
K ' = , - , , * G".
% « » + , @ > + . J ' = * G", ,G" * = @ ( , , ). K, @ * >* . " , -= , G". < @ + +-* . A= G": 30…62 , 250…300 . - = > , + ' * - . D ' 85 * 100 * . G" > 18 . # ' > ; -= + + (R<#) [ %.
. 11. # $ + ( + Deen A. et al., 2003)
- + - , ' + + ,> ' = , ' . " - > , + , ; =- , . " + * - @ . MO ,, = Q + . D ' @ + +,+ . O -
26
, ''O . G -+ * + ' ,
, .
", >@ - = ' , -. % , , +* + ' 8 * * - * . 1,6 , 5 . . ' O =>* . D-= ' .
G , , > + O > ' > , > ,' * , + 50 400 Q' @ > G". W *-+ . $= = > -= + G". D = > = > + @ . ? , >@ + @- , Q > O + , * = , >@ >. D Q >
+ * G" . K+ Q > O - Q @ > ' > . O ' -O ' ' . # G" + , ' * , –, >> = – ,' * , = .
D ' =:
+. + ' >@ + -
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+. D -+, ,
@ ( +, * +);
+. " > , G" *-' >@ + . -G" > * (- > = ) ' >@ * + ( , ).
# > = ' , >-
: ' = 150 * (45 |
* ; * ' ), - |
50 *, 2 |
*, 2 *, - |
27
* 1 *, 2,5 *. " - > [ % > . [ => , O, ' > > G", * @-Q O + Q .
" " - 2,5 , ->@ G" [ % = * . # ' , + . * , = + ' Q , - > * , ; + , - * + = * . # @=> * -' ' > -. @ : G".
" & |
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. " + @ 1 , + – +( O + ). , + , ' [ %.
J > , '' * [ % = (- >). 27 , 10 , 6 *. "+ , + > + +. = + * . " @=> - = * + + '[ %.
' * « = > », @O > ARM VII, =. '= , * = -. ; > , ' = ,, >@ . Intelligent Pill iPill – ; = * - . % ' * = * * = > + -. < , ' @= = = ' , ' = = * .
>@ iPill @ = 400 -, 10 . + + @ 1 - . + + > + ( +) -
28
* ' Q . # -@=> « » – ' ; * >, > . ; ** 1…3 .
W > (!W# [ % #D – + ; -[ % ) % ".". (< * %<R #D A!?<), ".C. !* (% # A) &.R. (# &? ) - + . " * * = -. ' > [ %,, = , >@ - . = , R<#, > > >, - > , > ; ' . Q - @ , ' , , ' += + ' . = ' = -; , : =>, , . . ? = Q = * * ;* ( ), -, Q > =, ;> Q + ; .
% «# <DA» +Q + + , ' >@ + -= .- + ( * - ) * = * . # ; * * , - , = + = * .+ * -+ + * * . A - > . W * > = = =>.
3.1.2.
$ M = * . & –G", ' @ = , > +* + . = ' M-' = , G" ' * , ' ; = * -* . * + M* = @ > O .
29
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