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Virtually Human

Glenn Allgood’s victim is heading for a battering. “I’d like to subject it to carcinogenic materials,” he muses. “I think you should be able to give it a suntan or a blister. I’m serious. I mean, you should be able to cut it. You should be able to have it cough up a hairball if you want to.”

Soon he might be able to do all that and more – without going to jail, and without causing anyone or anything a moment’s suffering. Allgood, a computational engineer at Oak Ridge National Laboratory in Tennessee is involved in creating the most complex computer model ever attempted: a virtual human being. It could take decades and billions of dollars to build it, but the dream of a Virtual Human is now becoming reality…

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Virtually Human

…The Virtual Human will have a living, breathing body whose cells will replicate and die, and whose blood will flow under Allgood’s knife. True, the Virtual Human will be alive only inside a computer but the simulated gash will provoke the same cascade of physiological reactions a real person experiences. Immune cells and clotting factors will rush to the wound, and biochemical stress reactions will reverberate throughout the body. The Virtual Human’s accurate simulation of human biochemistry will also mean it could test new drugs for us, and its realistic physical responses will allow the military to test the effects of the latest weaponry. In short, it will be given the worst job in the world: pharmaceutical guinea pig, crash test dummy and biologists’ action toy, all combined in one unlucky cyber-human…

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Virtually Human

… Virtual reality software being developed will allow researchers to see inside the Virtual Human’s organs, or watch its blood vessels dilate in response to drugs. They will even be able to set out on a journey inside the body using interactive “total immersion” software that will let them stand in the air-flow entering the lungs or listen to the flapping of faulty heart valves.

Being able to sit and watch the workings of the interconnections between different organs, map the whole body’s reaction to different chemicals or physical stimuli, or watch how a disease affects different areas of the body will also uncover invaluable new medical information…

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Virtually Human

…Computer models of human cells, organs and systems – ranging from the most basic representations to relatively sophisticated simulations of real biochemistry and function – were also out there, scattered among various academic and commercial laboratories.

The virtual heart developed by Denis Noble at the University of Oxford shows vividly how useful biological modeling can be. Noble’s heart is a carefully assembled mass of virtual cells, each processing virtual sugar and oxygen and behaving just like the real thing. Noble can watch his virtual heart beating on a computer screen. He can make it develop diseases, then treat it with virtual drugs. Drugs companies have used his heart to test for adverse reactions…

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