GANGLIONIC RECEPTOR BLOCKERS

1.Noncompetitive (Depolarizing)

♦Nicotine

2.Competitive (Non-depolarizing)

♦Hexamethonium

♦Mecamylamine

♦Trimethaphan

SITE PREDOMINANT TONE EFFECT OF GANGLIONIC BLOCKADE

	Predominant tone
Blood vessels	Sympathetic
Heart	Parasympathetic
Pupils	Parasympathetic
Ciliary muscle	Parasympathetic
GIT	Parasympathetic
GUT	Parasympathetic
Salivary glands	Parasympathetic
Sweat glands	Sympathetic
Sexual function	S and P

Effect/s

vasodilatation, hypotension

tachycardia

mydriasis

cycloplegia

constipation, decrease secretions

urinary retention

xerostomia

anhidrosis decrease stimulation

GANGLIONIC BLOCKERS

Therapeutic uses:

1.Hypertension

2.Acute dissecting aortic aneurysm

3.Autonomic hyperreflexia

NE transmission and the autonomic nervous system

Pharmacologic Actions:

4. Cardiac Excitatory Action – 1 receptor

♦Increase force of myocardial contraction

→(+) inotropic effect

♦Increase pacemaker activity

→(+) chronotropic effect

♦Increase conduction velocity in the A-V node and shortened refractory period

→(+) dromotropic effect

Classification of Cholinergic Receptors.

Muscarinic	Ach	Nicotinic

Smooth muscles
	ANS
Cardiac Muscles				NMJ			CNS
Exocrine/Endo	Ganglia
Glands/CNS