viii Contents
Partly Mature White Cell Precursors: Myelocytes and Metamyelo-
cytes . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .	36
Mature Neutrophils: Band Cells and Segmented Neutrophils . . . . .	38
Cell Degradation, Special Granulations, and Nuclear Appendages
in Neutrophilic Granulocytes and Nuclear Anomalies . . . . . . . . . . . .	40
Eosinophilic Granulocytes (Eosinophils) . . . . . . . . . . . . . . . . . . . . . . . .	44
Basophilic Granulocytes (Basophils) . . . . . . . . . . . . . . . . . . . . . . . . . . . .	44
Monocytes . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .	46
Lymphocytes (and Plasma Cells) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .	48
Megakaryocytes and Thrombocytes . . . . . . . . . . . . . . . . . . . . . . . . . . . .	50
Bone Marrow: Cell Composition and Principles of Analysis . . . .	52
Bone Marrow: Medullary Stroma Cells . . . . . . . . . . . . . . . . . . . . . . . . .	58
Abnormalities of the White Cell Series . . . . . . . . . . . . . . . . . .	61
Predominance of Mononuclear Round to Oval Cells . . . . . . . . . . .	63
Reactive Lymphocytosis . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .	66
Examples of Extreme Lymphocytic Stimulation: Infectious
Mononucleosis . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .	68
Diseases of the Lymphatic System (Non-Hodgkin Lymphomas) . . .	70
Differentiation of the Lymphatic Cells and Cell Surface Marker
Expression in Non-Hodgkin Lymphoma Cells . . . . . . . . . . . . . . . . .	72
Chronic Lymphocytic Leukemia (CLL) and Related Diseases . . . .	74
Lymphoplasmacytic Lymphoma . . . . . . . . . . . . . . . . . . . . . . . . . . . . .	78
Facultative Leukemic Lymphomas (e.g., Mantle Cell Lymphoma
and Follicular Lymphoma) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .	78
Lymphoma, Usually with Splenomegaly (e.g., Hairy Cell Leuke-
mia and Splenic Lymphoma with Villous Lymphocytes) . . . . . . .	80
Monoclonal Gammopathy (Hypergammaglobulinemia), Mul-
tiple Myeloma*, Plasma Cell Myeloma, Plasmacytoma . . . . . . . . .	82
Variability of Plasmacytoma Morphology . . . . . . . . . . . . . . . . . . . . .	84
Relative Lymphocytosis Associated with Granulocytopenia
(Neutropenia) and Agranulocytosis . . . . . . . . . . . . . . . . . . . . . . . . . . . .	86
Classification of Neutropenias and Agranulocytoses . . . . . . . . . . .	86
Monocytosis . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .	88
Acute Leukemias . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .	90
Morphological and Cytochemical Cell Identification . . . . . . . . . . .	91
Acute Myeloid Leukemias (AML) . . . . . . . . . . . . . . . . . . . . . . . . . . . . .	95
Acute Erythroleukemia (FAB Classification Type M6) . . . . . . . . . .	100
Acute Megakaryoblastic Leukemia
(FAB Classification Type M7) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .	102
AML with Dysplasia . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .	102
Hypoplastic AML . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .	102