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e364

Circulation

April 6, 2010

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802.Williams MA, Haskell WL, Ades PA, et al. Resistance exercise in individuals with and without cardiovascular disease: 2007 update: a scientific statement from the American Heart Association Council on Clinical Cardiology and Council on Nutrition, Physical Activity, and Metabolism. Circulation. 2007;116:572– 84.

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804.Hatzaras I, Tranquilli M, Coady M, et al. Weight lifting and aortic dissection: more evidence for a connection. Cardiology. 2007;107: 103– 6.

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809.Schermerhorn ML, Giles KA, Hamdan AD, et al. Population-based outcomes of open descending thoracic aortic aneurysm repair. J Vasc Surg. 2008.

810.Norgren L, Larzon T. Endovascular repair of the ruptured abdominal aortic aneurysm. Scand J Surg. 2008;97:178 – 81.

811.Troeng T. Volume versus outcome when treating abdominal aortic aneurysm electively: is there evidence to centralise? Scand J Surg. 2008;97:154 –9.

811a.Bonow RO, Masoudi FA, Rumsfeld JS, et al. ACC/AHA classification of care metrics: performance measures and quality metrics: a report of the American College of Cardiology/American Heart Assocation Task Force on Performance Measures. J Am Coll Cardiol. 2008;52:2113–7.

812.Estes NA III, Halperin JL, Calkins H, et al. ACC/AHA/Physician Consortium 2008 clinical performance measures for adults with nonvalvular atrial fibrillation or atrial flutter. J Am Coll Cardiol. 2008;51:865– 84.

813.Krumholz HM, Anderson JL, Brooks NH, et al. ACC/AHA clinical performance measures for adults with ST-elevation and non-ST- elevation myocardial infarction. J Am Coll Cardiol. 2006;47:236 – 65.

814.Thomas RJ, King M, Lui K, et al. AACVPR/ACC/AHA 2007 Performance measures on cardiac rehabilitation for referral to and delivery of cardiac rehabilitation/secondary prevention services. J Am Coll Cardiol. 2007;50:1400 –33.

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821.Kosseim M, Mayo NE, Scott S, et al. Ranking hospitals according to acute myocardial infarction mortality: should transfers be included? Med Care. 2006;44:664 –70.

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823.Reece TB, Green GR, Kron IL. Aortic dissection. In: Cohn LH, editor. Cardiac Surgery in the Adult. New York: McGraw-Hill, 2008;1195–222.

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826.Toda R, Moriyama Y, Masuda H, et al. Organ malperfusion in acute aortic dissection. Jpn J Thorac Cardiovasc Surg. 2000;48:545–50.

827.Dietz H, Deveraux R, Loeys BL. NHLBI working group research in Marfan syndrome and related disorders. Available at: Available at: http://www.nhlbi.nih.gov/meetings/workshops/marfan20070430.htm. Accessed January 7, 2010.

KEY WORDS: ACC/AHA Clinical Practice Guideline thoracic aortic diseasethoracic aortic dissection thoracic aortic aneurysm intramural hematoma genetic syndromes associated with thoracic aortic aneurysmemergency department acute thoracic aortic disease presentation and evaluation

Hiratzka et al

2010 Guidelines on Thoracic Aortic Disease

e365

Appendix 1. Author Relationships With Industry and Other Entities—2010 ACCF/AHA/AATS/ACR/ASA/SCA/SCAI/SIR/STS/SVM Guidelines for the Diagnosis and Management of Patients With Thoracic Aortic Disease

 

 

 

 

Ownership/

 

Institutional,

 

Committee

 

 

 

Partnership/

 

Organizational or Other

 

Member

Employment

Consultant

Speaker

Principal

Research

Financial Benefit

Expert Witness

 

 

 

 

 

 

 

 

Loren F.

Cardiac, Vascular & Thoracic

None

None

None

None

None

● 2007; Defense;

Hiratzka,

Surgeons Inc. and TriHealth

 

 

 

 

 

Aortic Dissection

Chair

Inc.—Medical Director,

 

 

 

 

 

 

 

Cardiac Surgery

 

 

 

 

 

 

George L.

University of Chicago

● Abbott

● Forest Laboratories

None

● Forest Laboratories

None

None

Bakris

Medical Center—Professor

● Boehringer Ingelheim

● GlaxoSmithKline

 

● GlaxoSmithKline

 

 

 

of Medicine; Director,

● Bristol-Myers

● Merck

 

● Myogen

 

 

 

Hypertension Center

Squibb/Sanofi-

● Novartis

 

● National Institutes

 

 

 

 

aventis

 

 

of Health (NIDDK/

 

 

 

 

● Forest Laboratories

 

 

NHLBI)

 

 

 

 

● GlaxoSmithKline

 

 

 

 

 

 

 

● Merck

 

 

 

 

 

Joshua A.

Brigham & Women’s

● Bristol-Myers Squibb

● Bristol-Myers

None

None

None

None

Beckman

Hospital—Director,

● Sanofi-aventis

Squibb

 

 

 

 

 

Cardiovascular Fellows

 

● GlaxoSmithKline

 

 

 

 

 

Program

 

● Merck

 

 

 

 

 

 

 

● Sanofi-aventis

 

 

 

 

Robert M.

Seattle Cardiology—Director,

● Abbott Vascular

● Boston Scientific

● Vascular

● Boston Scientific

● Boston Scientific

● Expert witness in

Bersin

Endovascular Services &

● Boston Scientific

● Bristol-Myers

Solutions

 

● Cordis Endovascular

a case involving

 

Clinical Research

● Bristol-Myers Squibb

Squibb

 

 

● Vascular Solutions

iatrogenic type B

 

 

● Cordis Endovascular

● Daiichi Sankyo

 

 

 

dissection

 

 

● Eli Lilly

● Eli Lilly

 

 

 

 

 

 

● EV3

● Sanofi-aventis

 

 

 

 

 

 

● Revascular

● The Medicines

 

 

 

 

 

 

● Theraputics

Company

 

 

 

 

 

 

● Sanfoi-aventis

 

 

 

 

 

 

 

● Vascular Solution

 

 

 

 

 

 

 

● W.L. Gore

 

 

 

 

 

Vincent F.

Uniformed Services

None

None

None

None

None

None

Carr

University of Health

 

 

 

 

 

 

 

Science—Professor of

 

 

 

 

 

 

 

Medicine

 

 

 

 

 

 

Donald E.

Atlantic Health—Vice

None

None

None

None

None

None

Casey, Jr

President of Quality & Chief

 

 

 

 

 

 

 

Medical Officer; Associate

 

 

 

 

 

 

 

Professor of Medicine,

 

 

 

 

 

 

 

Mount Sinai School of

 

 

 

 

 

 

 

Medicine

 

 

 

 

 

 

Kim A.

University of Michigan Health

● NHLBI

None

None

● Blue Cross/Blue

None

None

Eagle

System—Albion Walter

● Robert Wood

 

 

Shield

 

 

 

Professor of Internal

Johnson Foundation

 

 

● Bristol-Myers

 

 

 

Medicine; Clinical Director,

● Sanofi-aventis

 

 

Squibb

 

 

 

Cardiovascular Center

 

 

 

● National Institutes

 

 

 

 

 

 

 

of Health

 

 

 

 

 

 

 

● Pfizer

 

 

Luke K.

Mount Sinai Medical

None

None

None

None

None

None

Hermann

Center—Assistant Professor

 

 

 

 

 

 

 

of Emergency Medicine;

 

 

 

 

 

 

 

Director, Chest Pain Unit

 

 

 

 

 

 

Eric M.

Massachusetts General

None

None

None

None

None

● 2007; Plantiff;

Isselbacher

Hospital—Associate

 

 

 

 

 

Aortic Dissection

 

Professor of Medicine,

 

 

 

 

 

 

 

Harvard Medical School;

 

 

 

 

 

 

 

Co-Director, Thoracic Aortic

 

 

 

 

 

 

 

Center

 

 

 

 

 

 

Ella A.

University of Michigan Health

● GE Healthcare

None

None

None

● GERRAF (GE

None

Kazerooni

System—Professor of

● Vital Images

 

 

 

Radiology Research

 

 

Medicine; Director,

 

 

 

 

Fellowship)

 

 

Cardiothoracic Radiology

 

 

 

 

 

 

Nicholas T.

Missouri Baptist Medical

● Edwards Lifesciences

None

None

None

None

● 2006; Defense;

Kouchoukos

Center—Cardiovascular

 

 

 

 

 

Aortic Dissection

 

Surgeon

 

 

 

 

 

 

 

 

 

 

 

 

 

(Continued)

 

 

 

 

 

 

 

 

e366

Circulation

April 6, 2010

 

 

 

 

 

Appendix 1. Continued

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Ownership/

 

Institutional,

 

Committee

 

 

 

 

Partnership/

 

Organizational or Other

 

Member

Employment

 

Consultant

Speaker

Principal

Research

Financial Benefit

Expert Witness

 

 

 

 

 

 

 

 

Bruce W.

The Cleveland Clinic—Chair,

None

None

None

None

None

None

Lytle

Heart and Vascular Institute

 

 

 

 

 

 

Dianna M.

University of Texas

 

None

None

None

● Doris Duke

None

None

Milewicz

Southwestern Medical

 

 

 

Foundation

 

 

 

Center—President George

 

 

 

● Genetech

 

 

 

H.W. Bush Chair in

 

 

 

 

● National Institutes

 

 

 

Cardiovascular Medicine;

 

 

 

of Health

 

 

 

Professor & Director,

 

 

 

● Vivian Smith

 

 

 

Division of Medical Genetics

 

 

 

Foundation

 

 

David L.

Mount Sinai Medical

 

None

None

None

None

None

None

Reich

Center—Professor & Chair,

 

 

 

 

 

 

 

Department of

 

 

 

 

 

 

 

 

Anesthesiology

 

 

 

 

 

 

 

Souvik Sen

University of South Carolina

● Coaxia

● Boehringer

None

● American Heart

None

None

 

School of

 

● Bristol-Myers Squibb

Ingelheim

 

Association

 

 

 

Medicine–Professor and

● Pfizer

 

 

● Genetech

 

 

 

Chair, Department of

● Sanofi-aventis

 

 

● Sanofi-aventis

 

 

 

Neurology

 

 

 

 

 

 

 

Julie A.

Stanford University School of

None

None

None

None

None

None

Shinn

Medicine—Cardiovascular

 

 

 

 

 

 

 

Clinical Nurse Specialist

 

 

 

 

 

 

Lars G.

The Cleveland

 

None

None

None

● Edwards

None

None

Svensson

Clinic—Director, The Center

 

 

 

Lifesciences

 

 

 

for Aortic Surgery; Director,

 

 

 

● Evalve

 

 

 

Marfan Syndrome and

 

 

 

 

 

 

 

Collective Tissue Disorder

 

 

 

 

 

 

 

Clinic

 

 

 

 

 

 

 

David M.

University of Michigan Health

● W.L. Gore

None

None

● W.L. Gore

None

● 2000; Defense;

Williams

System—Professor,

 

 

 

 

● Medtronic

 

Failure to

 

Department of Radiology;

 

 

 

 

 

diagnose and

 

Director, Interventional

 

 

 

 

 

treat mesenteric

 

Radiology

 

 

 

 

 

 

ischemia with

 

 

 

 

 

 

 

 

aortic dissection

● 2009; Defense; Failure to diagnose and treat mesenteric ischemia with aortic dissection

NHLBI indicates National Heart, Lung, and Blood Institute; NIDDK, National Institute of Diabetes and Digestive and Kidney Diseases.

This table represents the relevant relationships of committee members with industry and other entities that were reported orally at the initial writing committee meeting and updated in conjunction with all meetings and conference calls of the writing committee during the document development process. It does not necessarily reflect relationships with industry at the time of publication. A person is deemed to have a significant interest in a business if the interest represents ownership of 5% or more of the voting stock or share of the business entity, or ownership of $10 000 or more of the fair market value of the business entity; or if funds received by the person from the business entity exceed 5% of the person’s gross income for the previous year. A relationship is considered to be modest if it is less than significant under the preceding definition. Relationships noted in this table are modest unless otherwise noted.

*Significant (greater than $10 000) relationship.

Hiratzka et al

2010 Guidelines on Thoracic Aortic Disease

e367

Appendix 2. Reviewer Relationships With Industry and Other Entities—2010 ACCF/AHA/AATS/ACR/ASA/SCA/SCAI/SIR/STS/SVM Guidelines for the Diagnosis and Management of Patients With Thoracic Aortic Disease

 

 

 

 

Ownership/

 

Institutional,

 

 

Peer

 

 

 

Partnership/

 

Organizational or Other

 

 

Reviewer

Representation

Consultant

Speaker

Principal

Research

Financial Benefit

Expert Witness

 

 

 

 

 

 

 

 

 

Amjad

Official Reviewer—Society

None

None

None

None

None

None

Almahameed

for Vascular Medicine

 

 

 

 

 

 

 

Richard A.

Official Reviewer—American

None

None

None

None

None

None

Bernstein

Stroke Association

 

 

 

 

 

 

 

Christopher

Official

None

None

None

None

None

None

E. Buller

Reviewer—ACCF/AHA Task

 

 

 

 

 

 

 

 

Force Lead Reviewer

 

 

 

 

 

 

 

Albert T.

Official Reviewer—Society of

● EKR Therapeutics

● EKR Therapeutics

None

● The Medicines

None

None

Cheung

Cardiovascular

● The Medicines

● The Medicines

 

Company*

 

 

 

 

Anesthesiologists

Company

Company

 

● Neuralstem*

 

 

 

 

 

● Neuralstem

● PDL Biopharm

 

● PDL Biopharm*

 

 

 

 

 

● Schering Plough

 

 

 

 

 

 

Michael D.

Official Reviewer—Society of

● W.L. Gore*

● Cook

None

● Cook

None

None

Dake

Interventional Radiologists

● Medtronic

 

 

● W.L. Gore*

 

 

 

 

 

 

 

 

● Medtronic

 

 

 

Antionette S.

Official Reviewer—AHA

None

None

None

None

None

None

Gomes

Cardiovascular Surgery and

 

 

 

 

 

 

 

 

Anesthesia Committee

 

 

 

 

 

 

 

Robert A.

Official Reviewer—ACCF

● Medtronic

None

None

None

None

None

Guyton

Board of Trustees

 

 

 

 

 

 

 

Clifford J.

Official Reviewer—Society

None

None

None

● Possis Corp.

None

None

Kavinsky

for Cardiovascular

 

 

 

 

 

 

 

 

Angiography and

 

 

 

 

 

 

 

 

Interventions

 

 

 

 

 

 

 

Scott Kinlay

Official Reviewer—Society

None

● Merck

None

● Pfizer

None

None

 

for Vascular Medicine

 

● Pfizer

 

 

 

 

 

Richard J.

Official Reviewer—ACCF

None

None

None

None

None

None

Kovacs

Board of Govenors

 

 

 

 

 

 

 

Christine

Official Reviewer—Society of

None

None

None

None

None

None

Mora

Cardiovascular

 

 

 

 

 

 

 

Mangano

Anesthesiologists

 

 

 

 

 

 

 

Steven R.

Official Reviewer—American

None

● Boehringer

None

● American Heart

None

None

Messé

Stroke Association

 

Ingelheim

 

Association*

 

 

 

Eric Roselli

Official Reviewer—Society of

● Medtronic

None

None

● Cook

None

None

 

Thoracic Surgeons

● Vascutek

 

 

 

 

 

 

Geoff D.

Official Reviewer—American

● Fovia

● Bracco

● TeraRecon

● Biosense-Webster*

None

None

Rubin

College of Radiology

 

 

 

 

 

 

 

Frank J.

Official Reviewer—American

● Bracco

● Bracco

● Siemens

● Bracco

None

None

Rybicki

College of Radiology

● Siemens Medical

● Siemens Medical

Medical

● Toshiba Medical

 

 

 

 

 

● Toshiba Medical

● Toshiba Medical

 

Systems*

 

 

 

 

 

Systems*

Systems*

 

 

 

 

 

 

 

● Vital Images

● Vital Images

 

 

 

 

 

Thoralf M.

Official Reviewer—American

None

None

None

● Bolton Medical

● Atricure

None

Sundt

Association for Thoracic

 

 

 

 

● Bolton Medical

 

 

 

Surgery

 

 

 

 

● Jarvik Heart

 

 

 

 

 

 

 

 

● Medtronic

 

 

 

 

 

 

 

 

● Sorin

 

 

 

 

 

 

 

 

Group/Carbomedics

 

 

 

 

 

 

 

 

● St. Jude Medical

 

 

 

 

 

 

 

 

● Thoratec

 

 

 

 

 

 

 

 

Corporation

 

 

 

 

 

 

 

 

● Ventracor

 

 

 

 

 

 

 

 

● W.L. Gore

 

 

Richard D.

Official Reviewer—AHA

None

None

None

None

None

None

White

Peripheral Vascular Disease

 

 

 

 

 

 

 

 

Council

 

 

 

 

 

 

 

 

 

 

 

 

 

 

(Continued)

 

 

 

 

 

 

 

 

 

e368

Circulation

April 6, 2010

 

 

 

 

 

 

Appendix 2. Continued

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Ownership/

 

Institutional,

 

 

Peer

 

 

 

 

Partnership/

 

Organizational or Other

 

 

Reviewer

Representation

 

Consultant

Speaker

Principal

Research

Financial Benefit

Expert Witness

 

 

 

 

 

 

 

 

 

James P.

Official Reviewer—Society

● Abbott Vascular

● Abbott Vascular

None

● Abbott Vascular

None

None

Zidar

for Cardiovascular

 

● Cordis*

● Cordis*

 

● Cordis*

 

 

 

 

Angiography and

 

● Medtronic Vascular

● Medtronic Vascular

 

● Medtronic Vascular

 

 

 

 

Interventions

 

 

 

 

 

 

 

 

Wyatt

Organizational

 

None

None

None

None

None

None

Decker

Reviewer—American College

 

 

 

 

 

 

 

 

of Emergency Physicians

 

 

 

 

 

 

 

Josh M.

Organizational

 

None

None

None

None

None

None

Kosowsky

Reviewer—American College

 

 

 

 

 

 

 

 

of Emergency Physicians

 

 

 

 

 

 

 

Emile

Organizational

 

None

None

None

None

None

None

Mohler

Reviewer—American College

 

 

 

 

 

 

 

 

of Physicians

 

 

 

 

 

 

 

 

James

Content Reviewer—ACCF

None

None

None

None

None

None

Burke

Catherization Committee

 

 

 

 

 

 

 

Edward P.

Content Reviewer

 

None

None

None

None

None

None

Chen

 

 

 

 

 

 

 

 

 

Mark A.

Content

 

None

None

None

None

None

None

Creager

Reviewer—ACCF/AHA Task

 

 

 

 

 

 

 

 

Force on Practice Guidelines

 

 

 

 

 

 

 

Jose G. Diez

Content Reviewer—ACCF

● Sanofi-aventis

None

None

None

None

None

 

Catherization Committee

 

 

 

 

 

 

 

John A.

Content Reviewer

 

● Baxter

None

● Coolspine

● Celera Diagnostics

None

● 2006; Plaintiff;

Elefteriades

 

 

 

 

 

 

 

Aortic Dissection*

D. Craig

Content Reviewer

 

● Medtronic

● St. Jude Medical

None

● NHLBI

None

None

Miller

 

 

 

 

 

● Stanford PARTNER

 

 

 

 

 

 

 

 

 

Trial

 

 

 

Rick

Content

 

None

None

None

None

None

None

Nishimura

Reviewer—ACCF/AHA Task

 

 

 

 

 

 

 

 

Force on Practice Guidelines

 

 

 

 

 

 

 

Patrick T.

Content Reviewer

 

None

None

None

None

None

None

O’Gara

 

 

 

 

 

 

 

 

 

Carlos Ruiz

Content Reviewer—ACCF

None

None

None

None

None

None

 

Interventional Council

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

ACCF indicates American College of Cardiology Foundation; AHA, American Heart Association; NHLBI, National Heart, Lung, and Blood Institute.

This table represents the relevant relationships with industry and other entities that were disclosed at the time of peer review. It does not necessarily reflect relationships with industry at the time of publication. A person is deemed to have a significant interest in a business if the interest represents ownership of 5% or more of the voting stock or share of the business entity, or ownership of $10 000 or more of the fair market value of the business entity; or if funds received by the person from the business entity exceed 5% of the person’s gross income for the previous year. A relationship is considered to be modest if it is less than significant under the preceding definition. Relationships in this table are modest unless otherwise noted. Names are listed in alphabetical order within each category of review.

*Significant (greater than $10 000) relationship.

Hiratzka et al

Appendix 3. Abbreviation List

AAA abdominal aortic aneurysm

AoD aortic dissection

CAD coronary artery disease

CSF cerebrospinal fluid

CT computed tomographic imaging

ECG electrocardiogram

GCA giant cell arteritis

IMH intramural hematoma

INR international normalized ratio

IRAD International Registry of Acute Aortic Dissection

MEP motor evoked potential

MI myocardial infarction

MMP matrix metalloproteinase

MR magnetic resonance imaging

PAU penetrating atherosclerotic ulcer

SSEP somatosensory evoked potentials

SSFP steady-state free precession

STEMI ST-elevation myocardial infarction

TAA thoracoabdominal aneurysm

TEE transesophageal echocardiogram

TIA transient ischemic attack

TRA traumatic rupture of the aorta

TTE transthoracic echocardiogram

UHC University HealthSystem Consortium

2010 Guidelines on Thoracic Aortic Disease

e369

Correction

In the article by Hiratzka et al, “2010 ACCF/AHA/AATS/ACR/ASA/SCA/SCAI/SIR/STS/ SVM Guidelines for the Diagnosis and Management of Patients With Thoracic Aortic Disease: A Report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines, American Association for Thoracic Surgery, American College of Radiology, American Stroke Association, Society of Cardiovascular Anesthesiologists, Society for Cardiovascular Angiography and Interventions, Society of Interventional Radiology, Society of Thoracic Surgeons, and Society for Vascular Medicine,” which published online March 16, 2010, and appeared with the April 6, 2010, issue of the journal (Circulation. 2010;121:e266-e369), several corrections were needed.

1.On page e309, in Section 8.6.2, right column, last paragraph, the first sentence read, “Multidetector CT, TEE, and MR all provide acceptable diagnostic accuracy for the diagnosis of acute AoD.” It should be changed to read, “Multidetector CT with contrast, TEE, and MR all provide acceptable diagnostic accuracy for the diagnosis of acute AoD.”

2.On page e310, in Figure 25, in the step 3 “Risk based diagnostic evaluation” section, T11 “Aortic Imaging Study,” the second bullet read, “CT (Image entire aorta: chest to pelvis).” It should be changed to read, “CT with contrast (Image entire aorta: chest to pelvis).” The revised figure is reproduced in its entirety on the next page.

(Circulation. 2013;128:e177-e178.)

© 2013 American Heart Association, Inc.

Circulation is available at http://circ.ahajournals.org DOI: 10.1161/CIR.0b013e3182a7f655

e177

e178    Circulation    September 10, 2013

STEP 1

Identify patients at risk for acute AoD

STEP 2

Bedside risk assessment

 

Consider acute AoD in all patients presenting with:

T1

 

 

 

 

Chest, back, or abdominal pain

 

 

Boxes with accompanying text are labeled and

 

Syncope

 

 

 

numbered with the

T

symbol.

 

Symptoms consistent with perfusion deficit

 

 

 

 

(i.e. CNS, mesenteric, myocardial, or limb ischemia)

 

 

 

 

Focused bedside pre-test risk assessment for acute AoD.

T2

 

 

High Risk Conditions

1

High Risk Pain Features

2

High Risk Exam Features

3

 

 

 

 

Chest, back, or abdominal

 

• Evidence of perfusion deficit

 

 

 

 

+

+

• Pulse deficit

 

 

 

• Marfan Syndrome

pain described as the

 

 

 

• Systolic BP differential

 

 

 

• Connective tissue disease

following:

 

 

 

• Focal neurologic deficit

 

 

 

• Family history aortic disease

 

• Abrupt in onset/ severe in

 

(in conjunction with pain)

 

 

 

• Known aortic valve disease

 

 

 

 

 

 

intensity

 

 

 

 

 

• Recent aortic manipulation

 

 

• Murmur of aortic insufficiency

 

 

 

 

and

 

 

 

 

• Known thoracic aortic aneurysm

 

(new or not known to be old

 

 

 

• Ripping/ tearing/ sharp or

 

 

 

 

 

 

 

and in conjunction with pain)

 

 

 

stabbing quality

• Hypotension or shock state

Determine pre-test risk by combination of risk conditions, history, and exam.

STEP 3

Risk based diagnostic evaluation

STEP 4

Acute AoD identified or excluded

Low Risk

T5

Intermediate Risk T4

High Risk

T3

No high risk features

 

Any single high risk

Two or more high risk

 

 

feature present.

 

present.

 

features present.

 

 

 

 

Proceed with diagnostic evaluation as clinically

indicated by presentation.

Alternative diagnosis identified?

Yes

No

Initiate appropriate therapy.

T9 Yes

Unexplained hypotension or widened mediastinum on CXR?

No

Consider aortic imaging study for TAD T10 based on clinical scenario (particularly in patients with advanced age, risk factors

for aortic disease, or syncope).

EKG consistent

Yes

with STEMI?

 

No

CXR with clear T7 Yes alternate diagnosis?

No

History and physical

exam strongly Yes suggestive of specific alternate diagnosis

No

T6

Likely primary ACS. In absence of other perfusion deficits strongly consider immediate coronary re-perfusion therapy. If coronary angiography performed is culprit lesion identified?

Yes

No

Initiate appropriate therapy.

Yes

Alternate diagnosis T8 confirmed by further testing?

No

Expedited aortic imaging

Aortic Imaging Study

T11

 

TEE (preferred if clinically unstable)

CT with contrast (Image entire aorta:

MR chest to pelvis)

If high clinical suspicion for T12

No

aortic dissection exists, consider

Aortic Dissection Present?

secondary imaging study.

 

Yes

Immediate surgical consultation and arrange for expedited aortic imaging.

Proceed to Treatment Pathway

Figure 25.  AoD evaluation pathway. ACS indicates acute coronary syndrome; AoD, aortic dissection; BP, blood pressure; CNS, central nervous system; CT, computed tomographic imaging; CXR, chest x-ray; EKG, electrocardiogram; MR, magnetic resonance imaging; STEMI, ST-elevation myocardial infarction; TAD; thoracic aortic disease; and TEE, transesophageal echocardiogram.

Data Supplement to: “2010 ACCF/AHA/AATS/ACR/ASA/SCA/SCAI/SIR/STS/SVM Guidelines for the Diagnosis and Management of Patients With Thoracic Aortic Disease: A Report of the American College of Cardiology Foundation/American Heart Association Force on Practice Guidelines, American Association for Thoracic Surgery, American College of Radiology, American Stroke Association, Society of Cardiovascular Anesthesiologists, Society for Cardiovascular Angiography and Interventions, Society Interventional Radiology, Society of Thoracic Surgeons, and Society for Vascular Medicine”

Technique Parameters and Anatomical Coverage for Thoracic Aortic Computed Tomography Studies

Scan Parameter

Parameter Specification

Comments

 

 

The mAs selected should result in diagnostic-quality images56

mAs

 

Should take into account the patient’s body habitus and age,

 

collimation, kVp, and unique attributes of the scanner and acquisition

 

 

 

 

mode56

Max.tube rotation

≤1 s57

 

time

 

 

kVp

120 to 140 kVp56

 

Collimation2

≤3 mm

 

Pitch (IEC

Between 1.0 and 1.75

 

definition)

 

 

 

 

 

60% ionic or 300 mg/mL nonionic contrast

IV contrast

 

Dense enhancement of the thoracic aorta that is sustained throughout

80 to 150 cc56

the sequence of scans may suggest an excessive contrast dose for the

medium

 

patient’s weight

 

 

Higher or lower volumes may be used if the protocol states that the

 

 

volume may be adjusted for patient weight

Oral contrast

N/A56

If used, oral contrast should not produce streaking artifact

Injection rate

3 to 5 mL/s56

 

 

 

The scan should be completed prior to visual evidence or significant

Scan delay

Computer assisted or

washout of intra-aortic contrast

empiric standardized56

This is best assessed in the chest by noting little or no difference

 

 

between intra-aortic density and muscle attenuation

Reconstruction

Standard or soft tissue56

 

algorithm

 

 

 

Should overlap at least

In situations where helical scans are reconstructed at overlapping

Reconstruction

50% of the slice thickness

intervals (eg, every 1.25 mm) for cine viewing on a workstation and

for helical scans if the

to obtain high-quality reconstructions, it is reasonable for every

spacing

capability of the scanner

second or third image to be photographed in an attempt to reduce the

 

 

used is <64 slices56

number of films required to display the entire study

CTDIvol

There are no reference

The CTDIvol should be appropriate for the examination

values for this examination

 

Above the aortic arch to at

 

 

least the level of the

 

Coverage

aortoiliac bifurcation56

 

(may include pelvic

 

 

arteries, particularly to

 

 

evaluate endovascular

 

 

repair access pathway)

 

Gantry tilt

N/A

 

Scan Parameter

Parameter Specification

Comments

 

Should not be so small that

 

 

a portion of the aorta is

 

Display FOV

excluded or so large that

 

edge of the image lies well

 

 

 

 

beyond the edge of the

 

 

patient’s body56

 

 

Lung and mediastinum56

 

 

Lung:

 

 

WW = 1200 to

The settings should allow adequate visualization of the aortic lumen

Display window

1500 HU

and should not display an aorta so dense that it is indistinguishable

width/level

WL = –550 to –700 HU

from cortical bone, or so hypodense that it is virtually

 

Mediastinum:

indistinguishable from normal soft-tissue (ie, chest wall musculature)

 

WW = 250 to 450

 

 

HU

 

 

WL = 40 to 80 HU

 

From: American College of Radiology. ACR CT Accreditation Clinical Image Quality Guide56; Fan et al.57

cc indicates cubic centimeter; CTDIvol, Computed Tomography Dose Index; FOV, field of view; HU, Hounsfield units; IEC, International Electrotechnical Commission; IV, intravenous; kVp, kilovolt peak; mAs, millimere seconds; N/A, not available; WL, window level; and WW, window width.