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3.8 Pelvic lymph node dissection (Table 3.13)

Laparoscopic pelvic lymph node dissection has a lower morbidity and a lower complication rate than open surgery (191, 192), with the same completeness of dissection as in open surgery (193-196). Large series have demonstrated the efficacy and safety of the procedure (197-200), indicating that the procedure is a valid alternative to open surgery for the staging of prostate cancer, prior to prostatic surgery or radiotherapy (201-214). Clinical results have been confirmed by an experimental randomized study in pigs (215).

Table 3.13 Pelvic lymph node dissection: guideline recommendations

Total number of patients

More than 1500

Expert opinion

Established

Level of evidence

2b

Grade of recommendation

В

Current indications

Prostate cancer staging

3.9 Radical prostatectomy (Table 3.14)

Laparoscopic radical prostatectomy presented a real challenge for the evolution of laparoscopy. The feasibility and safety of the procedure has been demonstrated by several studies (216-222), and has been performed using different techniques (transperitoneal, extraperitoneal, descending, ascending) with similar technical results. After a few years of clinical experience (223-225), it still remains a very demanding procedure which

requires significant laparoscopic expertize with an ongoing learning curve. The only comparative study (226) has shown that the oncological control of laparoscopic radical prostatectomy is similar to open surgery. The largest series showed good functional results (227). However, no long-term data are available and no Phase I studies have been performed to date. Because of the steeper learning curve, good results are achieved only after a long period of specific laparoscopic practice.

Table 3.14 Radical prostatectomy: guideline recommendations

Total number of patients

More than 500

Expert opinion

Feasible

Level of evidence

2b

Grade of recommendation

В

Current indications

Low prostate-specific antigen (PSA) intraprostatic cancer

3.10 Retroperitoneal lymph node dissection (for testicular cancer) (Table 3.15)

After the initial experience in pigs and humans demonstrating the feasibility of the technique (228-231), laparoscopic retroperitoneal lymph node dissection for stage I testicular cancer represents nowadays an alternative to surveillance and risk-adapted chemotherapy (232-233). It is superior to open surgery with respect to morbidity, has a lower complication rate than open surgery, and shows a similar completeness of dissection with long-term results equal to open surgery (232-244). A clinical comparative study (236) confirmed the data of experimental comparative studies in pigs (242-243). However, it is a difficult operation which requires a long learning curve and a good skill in laparoscopy.

The excision of residual tumour after chemotherapy in stage II testicular tumour is an experimental indication (245).

Table 3.15 Retroperitoneal lymph node dissection (for testicular cancer): guideline recommendations

Total number of patients

More than 300

Expert opinion

Feasible (Stage I)

Under evaluation (Stage II)

Level of evidence

3 (Stage I)

4 (Stage II)

Grade of recommendation

С

Current indications

Clinical stage I non-seminomatous testicular tumour

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