93,5% в группе плацебо не имели осложнений
Зачем 93,5% больных получили фрагмин?
За компанию…
Role of Inflammation in ACS.
Theory and Practice
Dr. R.Shakhnovich
BERLIN, 2006
THEORY
KEY MARKERS OF INFLAMMATION
Acute Phase reactants
-C-reactive protein
-Fibrinogen
-Serum amyloid A
Cytokines
-Interleukins (IL-1, IL-6, IL-
8, IL-10, IL-18
-Tissue necrosis factor-
-Monocyte chemoattractant protein (MCP-1)
-Ligand CD-40
- Lipoprotein-Associated
Phospholipase A2
Soluble Adhesion
Molecules
-E-selectin
-P-selectin
-s ICAM-1
-sVCAM-1
-Others markers of
Inflammation
-T-lymphocytes, foam cells
-free radicals
-neutrophils
-Albumin
-Plasminogen activator inhibitor (PAI-1)
THEORY
HIGH-SENSITIVITY C-REACTIVE PROTEIN AND RISKS OF FUTURE CARDIOVASCULAR EVENTS
JACC Vol. 48, No. 9 Suppl A A39 November 7, 2006:A33–46
THEORY
C-RP IN RELATION TO LONG-TERM MORTALITY IN UNSTABLE CORONARY ARTERY DISEASE
FRISC Study (n=917)
C-RP>10mg/l
P-0,001
C-RP- 2-10mg/l
C-RP<2mg/l
N Engl J Med 2000;343:1139-1147
THEORY
DETECTION OF C. PNEUMONIAE IN ATHEROSCLEROTIC PLAQUE
39%
79%
14%
71%
Emerging Infectious Diseases Vol. 4, No. 4, October-December 1998
THEORY
MEAN VALUES OF PATHAGEN BURDEN
2
р=0,003
р=0,032
1,5 1,58
1,42 1,41
1
р=0,007 0,95
0,5
0 
MI |
UA |
SA |
CONTROL |
THEORY
INFECTIOUS AND INFLAMMATORY MARKERS AND ONE YEAR PROGNOSIS IN PTS WITH ACS
(DEATH+MI+REPEAT HOSPITALIZATION +REVASCULARIZATION)
pathogen |
|
pathogen |
burden * |
|
burden * |
MI |
|
UA |
TNF- |
|
CMV * |
||||
(2 months) * |
||||
|
|
|
||
|
|
|
|
fibrinogen |
|
CRP |
|
CRP |
(2 months) * |
|
(2 weeks) * |
|
(2 weeks) * |
* - р<0,05
THEORY
DYNAMICS OF C-RP AND IL-6
IN PTS WITH ACS AND STABLE ANGINA
ACS |
Stable angina |
ACS |
Stable angina |
C-RP-1 |
C-RP-2 |
C-RP-3 |
IL-6-1 |
IL-6-2 |
IL-6-3 |
THEORY
CORRELATION BETWEEN INFLAMATORY MARKERS in pts ACS
IL-2 |
IL-6 |
C-RP |
C-RP |
IL-18 |
IL-18 |
C-RP |
C-RP |