- •Overview
- •Preface
- •Translator’s Note
- •Contents
- •1. Fundamentals
- •Microscopic Anatomy of the Nervous System
- •Elements of Neurophysiology
- •Elements of Neurogenetics
- •General Genetics
- •Neurogenetics
- •Genetic Counseling
- •2. The Clinical Interview in Neurology
- •General Principles of History Taking
- •Special Aspects of History Taking
- •3. The Neurological Examination
- •Basic Principles of the Neurological Examination
- •Stance and Gait
- •Examination of the Head and Cranial Nerves
- •Head and Cervical Spine
- •Cranial Nerves
- •Examination of the Upper Limbs
- •Motor Function and Coordination
- •Muscle Tone and Strength
- •Reflexes
- •Sensation
- •Examination of the Trunk
- •Examination of the Lower Limbs
- •Coordination and Strength
- •Reflexes
- •Sensation
- •Examination of the Autonomic Nervous System
- •Neurologically Relevant Aspects of the General Physical Examination
- •Neuropsychological and Psychiatric Examination
- •Psychopathological Findings
- •Neuropsychological Examination
- •Special Considerations in the Neurological Examination of Infants and Young Children
- •Reflexes
- •4. Ancillary Tests in Neurology
- •Fundamentals
- •Imaging Studies
- •Conventional Skeletal Radiographs
- •Computed Tomography (CT)
- •Magnetic Resonance Imaging (MRI)
- •Angiography with Radiological Contrast Media
- •Myelography and Radiculography
- •Electrophysiological Studies
- •Fundamentals
- •Electroencephalography (EEG)
- •Evoked potentials
- •Electromyography
- •Electroneurography
- •Other Electrophysiological Studies
- •Ultrasonography
- •Other Ancillary Studies
- •Cerebrospinal Fluid Studies
- •Tissue Biopsies
- •Perimetry
- •5. Topical Diagnosis and Differential Diagnosis of Neurological Syndromes
- •Fundamentals
- •Muscle Weakness and Other Motor Disturbances
- •Sensory Disturbances
- •Anatomical Substrate of Sensation
- •Disturbances of Consciousness
- •Dysfunction of Specific Areas of the Brain
- •Thalamic Syndromes
- •Brainstem Syndromes
- •Cerebellar Syndromes
- •6. Diseases of the Brain and Meninges
- •Congenital and Perinatally Acquired Diseases of the Brain
- •Fundamentals
- •Special Clinical Forms
- •Traumatic Brain injury
- •Fundamentals
- •Traumatic Hematomas
- •Complications of Traumatic Brain Injury
- •Intracranial Pressure and Brain Tumors
- •Intracranial Pressure
- •Brain Tumors
- •Cerebral Ischemia
- •Nontraumatic Intracranial Hemorrhage
- •Infectious Diseases of the Brain and Meninges
- •Infections Mainly Involving the Meninges
- •Infections Mainly Involving the Brain
- •Intracranial Abscesses
- •Congenital Metabolic Disorders
- •Acquired Metabolic Disorders
- •Diseases of the Basal Ganglia
- •Fundamentals
- •Diseases Causing Hyperkinesia
- •Other Types of Involuntary Movement
- •Cerebellar Diseases
- •Dementing Diseases
- •The Dementia Syndrome
- •Vascular Dementia
- •7. Diseases of the Spinal Cord
- •Anatomical Fundamentals
- •The Main Spinal Cord Syndromes and Their Anatomical Localization
- •Spinal Cord Trauma
- •Spinal Cord Compression
- •Spinal Cord Tumors
- •Myelopathy Due to Cervical Spondylosis
- •Circulatory Disorders of the Spinal Cord
- •Blood Supply of the Spinal Cord
- •Arterial Hypoperfusion
- •Impaired Venous Drainage
- •Infectious and Inflammatory Diseases of the Spinal Cord
- •Syringomyelia and Syringobulbia
- •Diseases Mainly Affecting the Long Tracts of the Spinal Cord
- •Diseases of the Anterior Horns
- •8. Multiple Sclerosis and Other Myelinopathies
- •Fundamentals
- •Myelin
- •Multiple Sclerosis
- •Other Demyelinating Diseases of Unknown Pathogenesis
- •9. Epilepsy and Its Differential Diagnosis
- •Types of Epilepsy
- •Classification of the Epilepsies
- •Generalized Seizures
- •Partial (Focal) Seizures
- •Status Epilepticus
- •Episodic Neurological Disturbances of Nonepileptic Origin
- •Episodic Disturbances with Transient Loss of Consciousness and Falling
- •Episodic Loss of Consciousness without Falling
- •Episodic Movement Disorders without Loss of Consciousness
- •10. Polyradiculopathy and Polyneuropathy
- •Fundamentals
- •Polyradiculitis
- •Cranial Polyradiculitis
- •Polyradiculitis of the Cauda Equina
- •Polyneuropathy
- •Fundamentals
- •11. Diseases of the Cranial Nerves
- •Fundamentals
- •Disturbances of Smell (Olfactory Nerve)
- •Neurological Disturbances of Vision (Optic Nerve)
- •Visual Field Defects
- •Impairment of Visual Acuity
- •Pathological Findings of the Optic Disc
- •Disturbances of Ocular and Pupillary Motility
- •Fundamentals of Eye Movements
- •Oculomotor Disturbances
- •Supranuclear Oculomotor Disturbances
- •Lesions of the Nerves to the Eye Muscles and Their Brainstem Nuclei
- •Ptosis
- •Pupillary Disturbances
- •Lesions of the Trigeminal Nerve
- •Lesions of the Facial Nerve
- •Disturbances of Hearing and Balance; Vertigo
- •Neurological Disturbances of Hearing
- •Disequilibrium and Vertigo
- •The Lower Cranial Nerves
- •Accessory Nerve Palsy
- •Hypoglossal Nerve Palsy
- •Multiple Cranial Nerve Deficits
- •12. Diseases of the Spinal Nerve Roots and Peripheral Nerves
- •Fundamentals
- •Spinal Radicular Syndromes
- •Peripheral Nerve Lesions
- •Fundamentals
- •Diseases of the Brachial Plexus
- •Diseases of the Nerves of the Trunk
- •13. Painful Syndromes
- •Fundamentals
- •Painful Syndromes of the Head And Neck
- •IHS Classification of Headache
- •Approach to the Patient with Headache
- •Migraine
- •Cluster Headache
- •Tension-type Headache
- •Rare Varieties of Primary headache
- •Symptomatic Headache
- •Painful Syndromes of the Face
- •Dangerous Types of Headache
- •“Genuine” Neuralgias in the Face
- •Painful Shoulder−Arm Syndromes (SAS)
- •Neurogenic Arm Pain
- •Vasogenic Arm Pain
- •“Arm Pain of Overuse”
- •Other Types of Arm Pain
- •Pain in the Trunk and Back
- •Thoracic and Abdominal Wall Pain
- •Back Pain
- •Groin Pain
- •Leg Pain
- •Pseudoradicular Pain
- •14. Diseases of Muscle (Myopathies)
- •Structure and Function of Muscle
- •General Symptomatology, Evaluation, and Classification of Muscle Diseases
- •Muscular Dystrophies
- •Autosomal Muscular Dystrophies
- •Myotonic Syndromes and Periodic Paralysis Syndromes
- •Rarer Types of Muscular Dystrophy
- •Diseases Mainly Causing Myotonia
- •Metabolic Myopathies
- •Acute Rhabdomyolysis
- •Mitochondrial Encephalomyopathies
- •Myositis
- •Other Diseases Affecting Muscle
- •Myopathies Due to Systemic Disease
- •Congenital Myopathies
- •Disturbances of Neuromuscular Transmission−Myasthenic Syndromes
- •15. Diseases of the Autonomic Nervous System
- •Anatomy
- •Normal and Pathological Function of the Autonomic Nervous System
- •Sweating
- •Bladder, Bowel, and Sexual Function
- •Generalized Autonomic Dysfunction
- •Index
258 13 Painful Syndromes
Neuralgic shoulder amyotrophy (p. 222) also causes |
alternative path for venous return and are thus more |
|
acute, severe pain. |
clearly visible than normal. The thrombosed vein itself |
|
|
can sometimes be palpated in the axilla and is tender. It |
|
Peripheral Nerve Conditions |
can often be unequivocally demonstrated with neuro- |
|
imaging studies and Doppler ultrasonography. The |
||
Compressive neuropathies can cause severe, in- |
||
prognosis is usually good; operative thrombectomy is |
||
tractable pain in the upper limb. These conditions are |
only rarely necessary. |
|
described in Chapter 12. The more common types are |
|
|
sulcus ulnaris syndrome (p. 232) and carpal tunnel syn- |
“Arm Pain of Overuse” |
|
drome (p. 228), which causes arm pain especially at |
||
night (brachialgia paraesthetica nocturna). |
The nonphysiological, prolonged, and repeated per- |
|
|
||
|
formance of specific movements of the upper limb(s), |
|
Vasogenic Arm Pain |
particularly at the workplace (e. g., typing, working at a |
|
cash register, or long and monotonous use of other kinds |
||
|
||
Arterial Diseases |
of machines), can produce intractable pain in the upper |
|
limb extending well beyond the muscles that were used |
||
Occlusion or stenosis of the subclavian a. causes dif- |
||
in the repeated movement. Pain of this type leads, in |
||
fuse arm pain on movement, forcing the patient to stop |
turn, to excessive reliance on other muscle groups, so |
|
using the limb (“intermittent claudication of the arm”). If |
that these, too, become involved in the pain syndrome. |
|
the artery is occluded proximal to the origin of the |
This condition and its pathogenesis are described |
|
vertebral a., the arm will be supplied with blood |
further under “Pseudoradicular Pain” (below). |
|
through retrograde flow in the vertebral a. Blood can be |
|
|
“stolen” in this way from the cerebral circulation (sub- |
Other Types of Arm Pain |
|
clavian steal syndrome): movement of the arm diverts |
||
blood flow away from the vertebrobasilar territory in |
Glomus tumors are small, benign growths that origi- |
|
the brain and lightheadedness or sudden falls (drop at- |
||
tacks) may result. Arterial insufficiency in the upper |
nate in the glomus organs of the skin. They are com- |
|
limb is demonstrated with the fist-clenching test: the |
posed of arteriovenous anastomoses in close association |
|
patient holds the upper limbs high, then rapidly and re- |
with autonomic fibers. Clinically, they are characterized |
|
peatedly clenches and reopens both hands. Pain arises |
by a dull pain that worsens when the arm hangs down |
|
within a few minutes on the poorly perfused side and |
and, particularly, when the arm swings as the patient |
|
the hand turns pale. When the arms are lowered again, |
walks. Local pressure over the tumor also causes pain. |
|
the veins on the dorsum of the hand fill slowly on the af- |
Glomus tumors are often found at the fingertips, where |
|
fected side. The arterial blood pressure is also always |
they may be visible as a bluish spot under the fingernail, |
|
lower when measured in the affected arm. |
but they can also arise practically anywhere else, includ- |
|
|
ing on the lower limbs. |
Venous Thrombosis
Occlusion of the axillary or subclavian v . This condition, also known as effort syndrome or Paget−von Schrötter syndrome, is seen most commonly in young men, usually on the right side. It is rarely spontaneous; more commonly, it arises after heavy use of the arm, e. g., in sports. The venous occlusion manifests itself as a painful tension in the arm, often accompanied by swelling. The subcutaneous veins in the region of the arm provide an
“Referred pain.” Diseases of the internal organs commonly cause referred pain in the shoulder and arm. Pain is felt in the right shoulder in gall bladder disease, for example, and in the left arm in angina pectoris.
Gout. An exacerbation of gout can produce extremely severe, acute pain in a hand (chiragra) or foot (podagra). Chiragra is sometimes, but not always, restricted to the metacarpophalangeal joint of the thumb.
Pain in the Trunk and Back
The back is by far the most common site of pain in the trunk. It is usually due to pathological abnormalities of the spine, which lead, in turn, to abnormal posture and nonphysiological activation of the muscles of the back.
Table 13.11 provides an overview of these painful syndromes, their localization, and the types of pain they produce. A few of them will be described in detail in the following paragraphs.
Mumenthaler / Mattle, Fundamentals of Neurology © 2006 Thieme All rights reserved. Usage subject to terms and conditions of license.
Pain in the Trunk and Back 259
Table 13.11 Overview of pain in the trunk and back
Designation |
Mechanism |
Localization and clinical features |
Remarks |
|
|
|
|
Pain in a band-like |
unior bilateral nerve root le- |
feeling of segmental tightening on |
e. g., spinal tumor, disk hernia- |
distribution |
sion |
one or both sides; continuous pain |
tion, herpes zoster |
Abnormally mobile |
pain on displacement of the |
unilateral pain at the costal margin, |
after thoracic trauma, or spon- |
10th rib (“slipping rib”) |
free end of the 10th rib |
on bending over or with local pres- |
taneous |
|
|
sure; the pain may be continuous |
|
Tear and hemorrhage |
lesion (rupture) of the rectus |
local pain in the abdominal wall |
rarely, compartment syndrome |
in the abdominal wall |
abdominis m., e. g., after stre- |
|
of the rectus abdominis m. |
musculature |
nuous exercise |
|
|
Spiegel hernia |
herniation next to the rectus |
pain at a paramedian location on the |
the pain disappears after the |
|
sheath, covered by the abdo- |
abdominal wall, local tenderness |
application of local anesthetic |
|
minal oblique m. and difficult |
|
|
|
to identify |
|
|
Rectus abdominis |
entrapment neuropathy; a me- |
abdominal wall pain on movement; |
differential diagnosis: inguinal |
syndrome |
dial cutaneous branch of one |
sometimes there is a coin-sized zone |
hernia, testicular torsion |
|
of the intercostal nerves is |
of cutaneous anesthesia |
|
|
caught in a gap in the fascia |
|
|
Ilioinguinal nerve |
compression of the ilioinguinal |
groin, external genitalia; dull, continu- |
|
syndrome |
n., or constriction by scar |
ous pain, worse on hip extension, |
|
|
|
better on flexion; objective sensory |
|
|
|
deficit in the distribution of the nerve |
|
“Referred pain” |
pain from internal organs pro- |
pain localization depends on the af- |
|
(zones of Head) |
jected to the surface of the |
fected organ; e. g., chest pain in |
|
|
trunk |
diseases of the heart and lungs, ab- |
|
|
|
dominal pain in GI diseases, lumbar |
|
|
|
pain in diseases of the retroperitoneal |
|
|
|
organs; typically a dull, piercing, or |
|
|
|
acute tearing pain |
|
Thoracoabdominal |
usually diabetic mononeuro- |
neuropathy |
pathy |
Ankylosing spondylitis |
in 90 % of cases, associated |
(Bekhterev disease) |
with the HLA-B27 histocompa- |
|
tibility antigen |
Spondylolisthesis and |
prolongation of the pars inter- |
spondylolysis |
articularis and ventral displace- |
|
ment of the cranial vertebra, |
|
ranging to spondyloptosis |
Sacroiliac strain |
tension on the ligamentous ap- |
|
paratus of the sacroiliac joint |
Notalgia paresthetica |
entrapment of the terminal |
|
sensory branch of the dorsal |
|
ramus of a spinal nerve in a |
|
fascial gap in the back |
continuous pain and paresthesiae of the thoracic or abdominal wall; diminished sensation, or unilateral weakness of abdominal wall muscles
the pain usually begins in the low lumbosacral region, usually at night; progressive thoracic kyphosis and diminishing mobility of the spine; rarely, pain in the chest and heels; typical radiologic findings
lower lumbar pain, worse on exertion and after prolonged standing; palpable “step” in the back; typical radiologic findings
low back pain, sometimes pseudoradicular radiation into the lower limbs; worse when the patient stands on one leg, or with the Mennell maneuver
local, unilateral pain in the back; objective local tenderness and a coinsized area of paravertebral cutaneous anesthesia
usually affects younger men
congenital anomaly; spondylolisthesis can be induced by mechanical stress or can occur spontaneously (in the latter case, usually as a symptom of an underlying condition); differential diagnosis: pseudospondylolisthesis in degenerative osteochondrosis
relieved by wearing a trochanteric belt
the pain disappears after the application of local anesthetic
Painful Syndromes
13
ThiemeARgoOneBoldThiemeArgoOne
Mumenthaler / Mattle, Fundamentals of Neurology © 2006 Thieme All rights reserved. Usage subject to terms and conditions of license.