- •Overview
- •Preface
- •Translator’s Note
- •Contents
- •1. Fundamentals
- •Microscopic Anatomy of the Nervous System
- •Elements of Neurophysiology
- •Elements of Neurogenetics
- •General Genetics
- •Neurogenetics
- •Genetic Counseling
- •2. The Clinical Interview in Neurology
- •General Principles of History Taking
- •Special Aspects of History Taking
- •3. The Neurological Examination
- •Basic Principles of the Neurological Examination
- •Stance and Gait
- •Examination of the Head and Cranial Nerves
- •Head and Cervical Spine
- •Cranial Nerves
- •Examination of the Upper Limbs
- •Motor Function and Coordination
- •Muscle Tone and Strength
- •Reflexes
- •Sensation
- •Examination of the Trunk
- •Examination of the Lower Limbs
- •Coordination and Strength
- •Reflexes
- •Sensation
- •Examination of the Autonomic Nervous System
- •Neurologically Relevant Aspects of the General Physical Examination
- •Neuropsychological and Psychiatric Examination
- •Psychopathological Findings
- •Neuropsychological Examination
- •Special Considerations in the Neurological Examination of Infants and Young Children
- •Reflexes
- •4. Ancillary Tests in Neurology
- •Fundamentals
- •Imaging Studies
- •Conventional Skeletal Radiographs
- •Computed Tomography (CT)
- •Magnetic Resonance Imaging (MRI)
- •Angiography with Radiological Contrast Media
- •Myelography and Radiculography
- •Electrophysiological Studies
- •Fundamentals
- •Electroencephalography (EEG)
- •Evoked potentials
- •Electromyography
- •Electroneurography
- •Other Electrophysiological Studies
- •Ultrasonography
- •Other Ancillary Studies
- •Cerebrospinal Fluid Studies
- •Tissue Biopsies
- •Perimetry
- •5. Topical Diagnosis and Differential Diagnosis of Neurological Syndromes
- •Fundamentals
- •Muscle Weakness and Other Motor Disturbances
- •Sensory Disturbances
- •Anatomical Substrate of Sensation
- •Disturbances of Consciousness
- •Dysfunction of Specific Areas of the Brain
- •Thalamic Syndromes
- •Brainstem Syndromes
- •Cerebellar Syndromes
- •6. Diseases of the Brain and Meninges
- •Congenital and Perinatally Acquired Diseases of the Brain
- •Fundamentals
- •Special Clinical Forms
- •Traumatic Brain injury
- •Fundamentals
- •Traumatic Hematomas
- •Complications of Traumatic Brain Injury
- •Intracranial Pressure and Brain Tumors
- •Intracranial Pressure
- •Brain Tumors
- •Cerebral Ischemia
- •Nontraumatic Intracranial Hemorrhage
- •Infectious Diseases of the Brain and Meninges
- •Infections Mainly Involving the Meninges
- •Infections Mainly Involving the Brain
- •Intracranial Abscesses
- •Congenital Metabolic Disorders
- •Acquired Metabolic Disorders
- •Diseases of the Basal Ganglia
- •Fundamentals
- •Diseases Causing Hyperkinesia
- •Other Types of Involuntary Movement
- •Cerebellar Diseases
- •Dementing Diseases
- •The Dementia Syndrome
- •Vascular Dementia
- •7. Diseases of the Spinal Cord
- •Anatomical Fundamentals
- •The Main Spinal Cord Syndromes and Their Anatomical Localization
- •Spinal Cord Trauma
- •Spinal Cord Compression
- •Spinal Cord Tumors
- •Myelopathy Due to Cervical Spondylosis
- •Circulatory Disorders of the Spinal Cord
- •Blood Supply of the Spinal Cord
- •Arterial Hypoperfusion
- •Impaired Venous Drainage
- •Infectious and Inflammatory Diseases of the Spinal Cord
- •Syringomyelia and Syringobulbia
- •Diseases Mainly Affecting the Long Tracts of the Spinal Cord
- •Diseases of the Anterior Horns
- •8. Multiple Sclerosis and Other Myelinopathies
- •Fundamentals
- •Myelin
- •Multiple Sclerosis
- •Other Demyelinating Diseases of Unknown Pathogenesis
- •9. Epilepsy and Its Differential Diagnosis
- •Types of Epilepsy
- •Classification of the Epilepsies
- •Generalized Seizures
- •Partial (Focal) Seizures
- •Status Epilepticus
- •Episodic Neurological Disturbances of Nonepileptic Origin
- •Episodic Disturbances with Transient Loss of Consciousness and Falling
- •Episodic Loss of Consciousness without Falling
- •Episodic Movement Disorders without Loss of Consciousness
- •10. Polyradiculopathy and Polyneuropathy
- •Fundamentals
- •Polyradiculitis
- •Cranial Polyradiculitis
- •Polyradiculitis of the Cauda Equina
- •Polyneuropathy
- •Fundamentals
- •11. Diseases of the Cranial Nerves
- •Fundamentals
- •Disturbances of Smell (Olfactory Nerve)
- •Neurological Disturbances of Vision (Optic Nerve)
- •Visual Field Defects
- •Impairment of Visual Acuity
- •Pathological Findings of the Optic Disc
- •Disturbances of Ocular and Pupillary Motility
- •Fundamentals of Eye Movements
- •Oculomotor Disturbances
- •Supranuclear Oculomotor Disturbances
- •Lesions of the Nerves to the Eye Muscles and Their Brainstem Nuclei
- •Ptosis
- •Pupillary Disturbances
- •Lesions of the Trigeminal Nerve
- •Lesions of the Facial Nerve
- •Disturbances of Hearing and Balance; Vertigo
- •Neurological Disturbances of Hearing
- •Disequilibrium and Vertigo
- •The Lower Cranial Nerves
- •Accessory Nerve Palsy
- •Hypoglossal Nerve Palsy
- •Multiple Cranial Nerve Deficits
- •12. Diseases of the Spinal Nerve Roots and Peripheral Nerves
- •Fundamentals
- •Spinal Radicular Syndromes
- •Peripheral Nerve Lesions
- •Fundamentals
- •Diseases of the Brachial Plexus
- •Diseases of the Nerves of the Trunk
- •13. Painful Syndromes
- •Fundamentals
- •Painful Syndromes of the Head And Neck
- •IHS Classification of Headache
- •Approach to the Patient with Headache
- •Migraine
- •Cluster Headache
- •Tension-type Headache
- •Rare Varieties of Primary headache
- •Symptomatic Headache
- •Painful Syndromes of the Face
- •Dangerous Types of Headache
- •“Genuine” Neuralgias in the Face
- •Painful Shoulder−Arm Syndromes (SAS)
- •Neurogenic Arm Pain
- •Vasogenic Arm Pain
- •“Arm Pain of Overuse”
- •Other Types of Arm Pain
- •Pain in the Trunk and Back
- •Thoracic and Abdominal Wall Pain
- •Back Pain
- •Groin Pain
- •Leg Pain
- •Pseudoradicular Pain
- •14. Diseases of Muscle (Myopathies)
- •Structure and Function of Muscle
- •General Symptomatology, Evaluation, and Classification of Muscle Diseases
- •Muscular Dystrophies
- •Autosomal Muscular Dystrophies
- •Myotonic Syndromes and Periodic Paralysis Syndromes
- •Rarer Types of Muscular Dystrophy
- •Diseases Mainly Causing Myotonia
- •Metabolic Myopathies
- •Acute Rhabdomyolysis
- •Mitochondrial Encephalomyopathies
- •Myositis
- •Other Diseases Affecting Muscle
- •Myopathies Due to Systemic Disease
- •Congenital Myopathies
- •Disturbances of Neuromuscular Transmission−Myasthenic Syndromes
- •15. Diseases of the Autonomic Nervous System
- •Anatomy
- •Normal and Pathological Function of the Autonomic Nervous System
- •Sweating
- •Bladder, Bowel, and Sexual Function
- •Generalized Autonomic Dysfunction
- •Index
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Examination of the Upper Limbs |
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sidered a pyramidal tract sign: forceful passive flexion of |
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a |
b |
the middle finger at the metacarpophalangeal joint is |
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normally followed by reflex adduction of the metacarpal |
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bone of the thumb (Fig. 3.27), but not if there is a lesion |
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in the pyramidal pathway. Another pyramidal tract sign |
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is flexion and opposition of the thumb when the ex- |
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aminer forcefully pulls on an actively flexed finger. |
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Sensation |
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Sensory testing takes time, patience, and good coopera- |
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tion from the patient. Its general purpose is to identify |
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any sensory deficit that may be present, delimit its site |
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and extent precisely, and determine which sensory |
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modalities are affected. The pattern of findings obtained |
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in this way usually permits classification of the causa- |
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tive lesion as central, radicular, or peripheral. During the |
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examination, the clinician must keep in mind what he |
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or she is looking for with each examining technique in |
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each part of the body where it is being applied. |
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c |
The sense of touch (esthesia) is tested with the patient’s |
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eyes closed. The examiner lightly touches various sites |
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on the patient’s body with a finger, a feather, a piece of |
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Fig. 3.26 Facilitation maneuvers make the intrinsic muscle reflexes |
tissue paper, or the like. Precise quantitative testing can |
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be performed with graded instruments, such as von Frey |
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more intense and easier to elicit. a Jendrassik hand grip. b Same ef- |
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fect with active, strong raising of the head off the headrest. c Active |
hairs or an adjustable Wartenberg pinwheel, but is not |
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plantar flexion of the foot. |
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necessary in routine practice. (Sharp pinwheels can also |
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transmit infectious diseases such as hepatitis and AIDS; |
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sterilization before each use is mandatory!) It generally |
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suffices to describe a deficit as either a deficient sense of |
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touch (hypesthesia) or an absent sense of touch (an- |
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esthesia). Depending on the clinical situation, the ex- |
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aminer may want to measure sensation quantitatively |
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in a particular dermatome or in the distribution of a par- |
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ticular peripheral nerve, or to compare sensation on |
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mirror-image sites on the body. |
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Two-point discrimination, stereognosis. The epicritic |
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component of the sense of touch (ultimately derived |
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from Greek krites, “judge”) is tested on the pads of the |
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fingers, e. g., by determining the patient’s ability to dis- |
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criminate two simultaneous stimuli located close to- |
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Fig. 3.27 The Mayer reflex of the metacarpophalangeal joint is |
gether. This can be done with a pair of calipers or simply |
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with the two points of an unfolded paper clip. The two |
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elicited by forceful passive flexion of the middle finger. Involuntary |
pointed ends are placed on the skin simultaneously, ini- |
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adduction of the thumb normally follows; absence of the reflex sug- |
tially very close together, and then at increasing dis- |
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gests a lesion of the pyramidal pathway. |
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tances until the patient reports feeling two separate |
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stimuli. The threshold distance is usually larger when |
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the stimuli are simultaneous than when they are suc- |
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cessively applied; on the fingertips, it should be no more |
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lower limb, because there are no “classic pyramidal tract |
than 5 mm. Epicritic sensation can also be tested by |
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signs” for the upper limb, as there are for the lower (cf. |
having the patient identify a coin by touch, or “read” a |
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p. 38). One important clue is exaggeration of the physio- |
number written on the patient’s fingertip. Normal per- |
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logical intrinsic muscle reflexes, especially if asym- |
formance on these tests also requires intact stereogno- |
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metric. Two others are spreading of the reflex zones and |
sis. |
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unusual briskness of certain intrinsic reflexes that, |
Vibration and position sense. Vibration sense (pal- |
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under normal circumstances, are only barely elicitable, |
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or not at all, e. g., the trapezius and pectoralis reflexes |
lesthesia) is tested with a vibrating 64or 124-Hz tuning |
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(cf. Table 3.5). The Trömner reflex and Hoffmann sign |
fork solidly placed on various bony prominences of the |
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can also be of pathological significance if abnormally |
body, i. e., sites where the bone is covered only by skin. |
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brisk or unilaterally exaggerated. Absence of the Mayer |
The intensity of vibration can be graduated, if desired, |
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reflex of the metacarpophalangeal joint is also con- |
with the aid of special adjustable tuning forks, such as |
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ARgo |
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ARgo leicht |
argo |
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Mumenthaler / Mattle, Fundamentals of Neurology © 2006 Thiemealöb |
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auch Argo
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35
3
The Neurological Examination