- •Overview
- •Preface
- •Translator’s Note
- •Contents
- •1. Fundamentals
- •Microscopic Anatomy of the Nervous System
- •Elements of Neurophysiology
- •Elements of Neurogenetics
- •General Genetics
- •Neurogenetics
- •Genetic Counseling
- •2. The Clinical Interview in Neurology
- •General Principles of History Taking
- •Special Aspects of History Taking
- •3. The Neurological Examination
- •Basic Principles of the Neurological Examination
- •Stance and Gait
- •Examination of the Head and Cranial Nerves
- •Head and Cervical Spine
- •Cranial Nerves
- •Examination of the Upper Limbs
- •Motor Function and Coordination
- •Muscle Tone and Strength
- •Reflexes
- •Sensation
- •Examination of the Trunk
- •Examination of the Lower Limbs
- •Coordination and Strength
- •Reflexes
- •Sensation
- •Examination of the Autonomic Nervous System
- •Neurologically Relevant Aspects of the General Physical Examination
- •Neuropsychological and Psychiatric Examination
- •Psychopathological Findings
- •Neuropsychological Examination
- •Special Considerations in the Neurological Examination of Infants and Young Children
- •Reflexes
- •4. Ancillary Tests in Neurology
- •Fundamentals
- •Imaging Studies
- •Conventional Skeletal Radiographs
- •Computed Tomography (CT)
- •Magnetic Resonance Imaging (MRI)
- •Angiography with Radiological Contrast Media
- •Myelography and Radiculography
- •Electrophysiological Studies
- •Fundamentals
- •Electroencephalography (EEG)
- •Evoked potentials
- •Electromyography
- •Electroneurography
- •Other Electrophysiological Studies
- •Ultrasonography
- •Other Ancillary Studies
- •Cerebrospinal Fluid Studies
- •Tissue Biopsies
- •Perimetry
- •5. Topical Diagnosis and Differential Diagnosis of Neurological Syndromes
- •Fundamentals
- •Muscle Weakness and Other Motor Disturbances
- •Sensory Disturbances
- •Anatomical Substrate of Sensation
- •Disturbances of Consciousness
- •Dysfunction of Specific Areas of the Brain
- •Thalamic Syndromes
- •Brainstem Syndromes
- •Cerebellar Syndromes
- •6. Diseases of the Brain and Meninges
- •Congenital and Perinatally Acquired Diseases of the Brain
- •Fundamentals
- •Special Clinical Forms
- •Traumatic Brain injury
- •Fundamentals
- •Traumatic Hematomas
- •Complications of Traumatic Brain Injury
- •Intracranial Pressure and Brain Tumors
- •Intracranial Pressure
- •Brain Tumors
- •Cerebral Ischemia
- •Nontraumatic Intracranial Hemorrhage
- •Infectious Diseases of the Brain and Meninges
- •Infections Mainly Involving the Meninges
- •Infections Mainly Involving the Brain
- •Intracranial Abscesses
- •Congenital Metabolic Disorders
- •Acquired Metabolic Disorders
- •Diseases of the Basal Ganglia
- •Fundamentals
- •Diseases Causing Hyperkinesia
- •Other Types of Involuntary Movement
- •Cerebellar Diseases
- •Dementing Diseases
- •The Dementia Syndrome
- •Vascular Dementia
- •7. Diseases of the Spinal Cord
- •Anatomical Fundamentals
- •The Main Spinal Cord Syndromes and Their Anatomical Localization
- •Spinal Cord Trauma
- •Spinal Cord Compression
- •Spinal Cord Tumors
- •Myelopathy Due to Cervical Spondylosis
- •Circulatory Disorders of the Spinal Cord
- •Blood Supply of the Spinal Cord
- •Arterial Hypoperfusion
- •Impaired Venous Drainage
- •Infectious and Inflammatory Diseases of the Spinal Cord
- •Syringomyelia and Syringobulbia
- •Diseases Mainly Affecting the Long Tracts of the Spinal Cord
- •Diseases of the Anterior Horns
- •8. Multiple Sclerosis and Other Myelinopathies
- •Fundamentals
- •Myelin
- •Multiple Sclerosis
- •Other Demyelinating Diseases of Unknown Pathogenesis
- •9. Epilepsy and Its Differential Diagnosis
- •Types of Epilepsy
- •Classification of the Epilepsies
- •Generalized Seizures
- •Partial (Focal) Seizures
- •Status Epilepticus
- •Episodic Neurological Disturbances of Nonepileptic Origin
- •Episodic Disturbances with Transient Loss of Consciousness and Falling
- •Episodic Loss of Consciousness without Falling
- •Episodic Movement Disorders without Loss of Consciousness
- •10. Polyradiculopathy and Polyneuropathy
- •Fundamentals
- •Polyradiculitis
- •Cranial Polyradiculitis
- •Polyradiculitis of the Cauda Equina
- •Polyneuropathy
- •Fundamentals
- •11. Diseases of the Cranial Nerves
- •Fundamentals
- •Disturbances of Smell (Olfactory Nerve)
- •Neurological Disturbances of Vision (Optic Nerve)
- •Visual Field Defects
- •Impairment of Visual Acuity
- •Pathological Findings of the Optic Disc
- •Disturbances of Ocular and Pupillary Motility
- •Fundamentals of Eye Movements
- •Oculomotor Disturbances
- •Supranuclear Oculomotor Disturbances
- •Lesions of the Nerves to the Eye Muscles and Their Brainstem Nuclei
- •Ptosis
- •Pupillary Disturbances
- •Lesions of the Trigeminal Nerve
- •Lesions of the Facial Nerve
- •Disturbances of Hearing and Balance; Vertigo
- •Neurological Disturbances of Hearing
- •Disequilibrium and Vertigo
- •The Lower Cranial Nerves
- •Accessory Nerve Palsy
- •Hypoglossal Nerve Palsy
- •Multiple Cranial Nerve Deficits
- •12. Diseases of the Spinal Nerve Roots and Peripheral Nerves
- •Fundamentals
- •Spinal Radicular Syndromes
- •Peripheral Nerve Lesions
- •Fundamentals
- •Diseases of the Brachial Plexus
- •Diseases of the Nerves of the Trunk
- •13. Painful Syndromes
- •Fundamentals
- •Painful Syndromes of the Head And Neck
- •IHS Classification of Headache
- •Approach to the Patient with Headache
- •Migraine
- •Cluster Headache
- •Tension-type Headache
- •Rare Varieties of Primary headache
- •Symptomatic Headache
- •Painful Syndromes of the Face
- •Dangerous Types of Headache
- •“Genuine” Neuralgias in the Face
- •Painful Shoulder−Arm Syndromes (SAS)
- •Neurogenic Arm Pain
- •Vasogenic Arm Pain
- •“Arm Pain of Overuse”
- •Other Types of Arm Pain
- •Pain in the Trunk and Back
- •Thoracic and Abdominal Wall Pain
- •Back Pain
- •Groin Pain
- •Leg Pain
- •Pseudoradicular Pain
- •14. Diseases of Muscle (Myopathies)
- •Structure and Function of Muscle
- •General Symptomatology, Evaluation, and Classification of Muscle Diseases
- •Muscular Dystrophies
- •Autosomal Muscular Dystrophies
- •Myotonic Syndromes and Periodic Paralysis Syndromes
- •Rarer Types of Muscular Dystrophy
- •Diseases Mainly Causing Myotonia
- •Metabolic Myopathies
- •Acute Rhabdomyolysis
- •Mitochondrial Encephalomyopathies
- •Myositis
- •Other Diseases Affecting Muscle
- •Myopathies Due to Systemic Disease
- •Congenital Myopathies
- •Disturbances of Neuromuscular Transmission−Myasthenic Syndromes
- •15. Diseases of the Autonomic Nervous System
- •Anatomy
- •Normal and Pathological Function of the Autonomic Nervous System
- •Sweating
- •Bladder, Bowel, and Sexual Function
- •Generalized Autonomic Dysfunction
- •Index
260 13 Painful Syndromes
Thoracic and Abdominal Wall Pain |
back. Spondylolisthesis, the sliding of one vertebral body |
on another (with or without spondylolysis, i. e., a defect |
|
Diseases of the internal organs are the most common |
of the pars interarticularis of the vertebral arch), is a |
congenital anomaly that usually remains clinically |
|
cause of pain in the thoracic and abdominal wall (see |
silent until later in life. It sometimes becomes sympto- |
“referred pain,” above). Chest pain is often due to dis- |
matic after an accident. |
eases of the heart and lungs. Band-like pain suggests a |
Pathological changes of the sacroiliac joint typically |
(possibly intraspinal) process irritating one of the spinal |
|
nerve roots or segmental nerves. Abdominal wall pain |
produce pain that worsens when the patient stands on |
often arises from the internal organs, but may also be |
one leg or hyperextends the leg on the affected side |
due, for example, to compression of the ventral rami of |
(Mennell maneuver). |
the spinal nerve roots (e. g., compression of the caudal |
Entrapment neuropathies are responsible for some |
thoracic nerves in the rectus abdominis syndrome). The |
|
rare Spiegel hernia (cf. Table 13.11) is another possibility, |
cases of back pain of nonskeletal origin. Notalgia pares- |
as is an abnormally mobile tenth rib. |
thetica, for example, is a rare entrapment neuropathy of |
|
the sensory dorsal rami of the thoracic spinal nerves as |
Back Pain |
they pass through small apertures in the fascia (see |
p. 232). |
|
Back pain is a very common problem that often pro- |
Coccygodynia , i. e., intractable pain in the region of the |
foundly affects the sufferer’s everyday life at work and |
coccyx, can arise after local trauma (a fall on the but- |
at home. The pain cannot always be fully explained |
tocks) or spontaneously. In the latter case, the diagnos- |
based on objectively demonstrable skeletal changes. |
tic evaluation should include a search for tumors or in- |
The extent of the visible structural changes is often not |
fectious/inflammatory changes in the pelvis, as well as |
commensurate with the intensity of the pain. The major |
cysts of the lumbosacral nerve root sleeves (= Tarlov |
causes of back pain are: |
cysts). |
Structural changes of the spine cause the vast major- |
Groin Pain |
ity of cases of back pain. Osteochondrosis leads to reac- |
|
tive spondylotic changes and, therefore, increased stress |
Pain in the groin can be caused not only by bladder con- |
on the intervertebral joints. This, in turn, causes faulty |
|
posture, reflex functional disturbances of the muscula- |
ditions, gynecologic diseases, and inguinal hernias, but |
ture, and, therefore, pain. A herniated intervertebral disk |
also by peripheral nerve lesions. The ilioinguinal nerve |
can compress a nerve root, producing acute pain radiat- |
syndrome, a type of entrapment neuropathy, is de- |
ing into the periphery (p. 210). Abnormal postures of the |
scribed in Table 13.11. The pain of spermatic neuralgia is |
spine, as in ankylosing spondylitis or scoliosis, often |
felt in the scrotum. In general, when the cause of groin |
cause intractable back pain because of the associated |
pain is unclear, a pathological process should be sought |
nonphysiological stress on the muscles of the trunk and |
in the pelvis. |
Leg Pain
Pain in the leg, like pain in the arm, has many causes. Common causes are degenerative and traumatic joint and soft tissue processes, lumbar disk herniation, and pathology in the lumbar spinal canal. Others include polyneuropathies, entrapment neuropathies, and restless legs syndrome.
Vascular diseases, too, play an important role, particularly arterial occlusive disease.
Pain in the hip is usually due to diseases of the hip joint, most often degenerative arthritis (coxarthrosis). A diagnosis that is often missed is periarthropathy of the hip: in this condition, the joint itself is not diseased, but the soft tissues around it give rise to intractable pain, which frequently lasts for months. In algodystrophy of the hip, local pain is followed, some time afterward, by the development of osteopenia of the femoral head. Both the pain and the osteopenia usually resolve spontaneously.
Thigh pain may be due to a local process such as a sarcoma. An upper lumbar disk herniation or other lesion causing nerve root irritation can produce referred pain in the thigh. Meralgia paresthetica, a type of entrapment neuropathy causing pain in the thigh, is described on p. 234. Acute thigh pain and femoral nerve palsy can be caused either by diabetic neuropathy or by a hematoma in the psoas sheath.
Knee pain is usually of orthopedic, rheumatological, or traumatic origin. A proximal lesion of the obturator n. produces referred pain in the popliteal fossa in Howship−Romberg syndrome (p. 236). Spontaneous or mechanically induced lesions of the infrapatellar branch of the saphenous n. are a further cause of pain in the knee.
Pain in the lower leg that is present only when the patient walks is typical of vasogenic intermittent claudication, a syndrome whose cause usually lies in the arteries, less commonly in the veins. Neurogenic intermit-
Mumenthaler / Mattle, Fundamentals of Neurology © 2006 Thieme All rights reserved. Usage subject to terms and conditions of license.
Pseudoradicular Pain 261
tent claudication is caused by compression of the cauda equina in lumbar spinal stenosis (p. 213). Vasogenic intermittent claudication is worse when the patient walks uphill, while the neurogenic type is worse when the patient walks downhill. In the anterior tibial artery syndrome, pain develops acutely on the anterior aspect of the lower leg, particularly with exercise (p. 239). The saphenous n. can be caught in a fascial gap on the medial side of the lower leg, or, alternatively, in Hunter’s canal in the thigh; pain ensues in the cutaneous zone innervated by this nerve (entrapment neuropathy).
Pain in the foot is a common complaint. It is usually unilateral and caused by an orthopedic condition, or by trauma. Tarsal tunnel syndrome, which typically arises
after an ankle sprain, causes pain in the sole of the foot when the patient walks; it is described on p. 241. Morton’s metatarsalgia is described in the same section. Bilateral, burning pain in the feet characterizes erythromelalgia of vasomotor origin, otherwise known as burning feet syndrome. Similar symptoms may arise in polyneuropathy, but are then usually accompanied by objective neurological findings (loss of Achilles reflexes, distal sensory deficit). In “restless legs syndrome,” the restlessness, which is perceived as painful, forces the sufferer to stand up, walk around, and move the legs time and again, particularly at night or after prolonged sitting in a soft chair. This syndrome usually responds to small doses of L-DOPA, as well as to dopamine agonists.
Pseudoradicular Pain
This term denotes an etiologically heterogeneous collection of painful syndromes caused by a faulty synergy of the muscles and joints. The faulty synergy arises either from structural joint changes or from nonphysiological movements putting excessive stress on the musculoskeletal system.
Pathophysiology. The joints of the body have a continuous, dynamic relationship with the muscles that move them. Afferent nerve impulses arising in the joints are fed back to the muscles to regulate and coordinate the timing and strength of muscle contraction. Thus, pathological impulses arising from mechanically damaged or otherwise dysfunctional joints lead to nonphysiologic patterns of muscle activation. In addition, movements that are repeated monotonously or that put the joints in an unfavorable position (“nonergonomic” movements) cause pain of the participating anatomic structures through overuse. Different names are used for the resulting pain syndromes, depending on the specialty and school of thought of the physician or other expert consulted: tendomyalgia, tendomyosis, pseudoradicular pain, myofascial syndrome, muscular rheumatism, and so forth.
Clinical manifestations. Pseudoradicular pain can arise in many different regions of the body but is particularly common in the upper limb. The pain is chronic and difficult to treat, because it is constantly reactivated by the daily (over)use of the involved joints and muscles.
The general features of pseudoradicular pain are as follows:
the pain is of greater or lesser intensity,
usually radiates into a single limb,
is exacerbated by the use of this limb,
and causes an antalgic restriction of movement;
there are painful trigger points and painful tendon attachments;
there is no objectifiable sensory deficit, paresis, or reflex abnormality;
nonphysiologic, antalgic movement leads to the perpetuation, extension, and chronification of the pain.
Treatment and prognosis. This condition is difficult to treat. The most useful approach consists of good occupational hygiene (use of the affected muscles only up to the pain threshold), changing the illness-producing behavior (switch to a different task at work), and passive measures such as trigger-point therapy. Much patience is demanded of both doctor and patient.
Painful Syndromes
13
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Mumenthaler / Mattle, Fundamentals of Neurology © 2006 Thieme All rights reserved. Usage subject to terms and conditions of license.