- •November 16, 2002
- •February 14, 2003
- •February 21
- •February 28
- •March 7
- •March 10
- •March 12
- •March 14
- •March 15
- •March 17
- •March 19
- •March 21
- •March 24
- •March 26
- •March 28
- •March 30
- •March 31
- •April 2
- •April 2
- •April 8-10
- •April 12
- •April 16
- •April 20
- •April 20
- •April 23
- •April 25
- •April 27
- •April 29
- •June 6
- •June 13
- •June 17
- •June 21
- •June 23
- •June 24
- •July 2
- •July 5
- •August 14
- •September 8
- •September 24
- •References
- •Virology
- •Discovery of the SARS Virus
- •Initial Research
- •The Breakthrough
- •Coronaviridae
- •SARS Co-V
- •Genome Sequence
- •Morphology
- •Organization
- •Detection
- •Stability and Resistance
- •Natural Host
- •Antiviral Agents and Vaccines
- •Antiviral Drugs
- •Vaccines
- •Outlook
- •References
- •Routes of Transmission
- •Factors Influencing Transmission
- •Patient Factors in Transmission
- •Asymptomatic Patients
- •Symptomatic Patients
- •Superspreaders
- •The Unsuspected Patients
- •High-Risk Activities
- •Transmission during Quarantine
- •Transmission after Recovery
- •Animal Reservoirs
- •Conclusion
- •References
- •Introduction
- •Modeling the Epidemic
- •Starting Point
- •Global Spread
- •Hong Kong
- •Vietnam
- •Toronto
- •Singapore, February 2003
- •China
- •Taiwan
- •Other Countries
- •Eradication
- •Outlook
- •References
- •Introduction
- •International Coordination
- •Advice to travelers
- •Management of SARS in the post-outbreak period
- •National Measures
- •Legislation
- •Extended Case Definition
- •Quarantine
- •Reduce travel between districts
- •Quarantine after Discharge
- •Infection Control in Healthcare Settings
- •General Measures
- •Protective Measures
- •Hand washing
- •Gloves
- •Face Masks
- •Additional protection
- •Getting undressed
- •Special Settings
- •Intensive Care Units
- •Intubating a SARS Patient
- •Anesthesia
- •Triage
- •Internet Sources
- •Additional information
- •Infection Control in Households
- •Possible Transmission from Animals
- •After the Outbreak
- •Conclusion
- •References
- •Case Definition
- •WHO Case Definition
- •Suspect case
- •Probable case
- •Exclusion criteria
- •Reclassification of cases
- •CDC Case Definition
- •Diagnostic Tests
- •Introduction
- •Laboratory tests
- •Molecular tests
- •Virus isolation
- •Antibody detection
- •Interpretation
- •Limitations
- •Biosafety considerations
- •Outlook
- •Table, Figures
- •References
- •Clinical Presentation and Diagnosis
- •Clinical Presentation
- •Hematological Manifestations
- •Atypical Presentation
- •Chest Radiographic Abnormalities
- •Chest Radiographs
- •CT Scans
- •Diagnosis
- •Clinical Course
- •Viral Load and Immunopathological Damage
- •Histopathology
- •Lung Biopsy
- •Postmortem Findings
- •Discharge and Follow-up
- •Psychosocial Issues
- •References
- •Appendix: Guidelines
- •WHO: Management of Severe Acute Respiratory Syndrome (SARS)
- •Management of Suspect and Probable SARS Cases
- •Definition of a SARS Contact
- •Management of Contacts of Probable SARS Cases
- •Management of Contacts of Suspect SARS Cases
- •SARS Treatment
- •Antibiotic therapy
- •Antiviral therapy
- •Ribavirin
- •Neuraminidase inhibitor
- •Protease inhibitor
- •Human interferons
- •Human immunoglobulins
- •Alternative medicine
- •Immunomodulatory therapy
- •Corticosteroids
- •Other immunomodulators
- •Assisted ventilation
- •Non-invasive ventilation
- •Invasive mechanical ventilation
- •Clinical outcomes
- •Outlook
- •Appendix 1
- •A standardized treatment protocol for adult SARS in Hong Kong
- •Appendix 2
- •A treatment regimen for SARS in Guangzhou, China
- •References
- •Pediatric SARS
- •Clinical Manifestation
- •Radiologic Features
- •Treatment
- •Clinical Course
- •References
Global Spread 73
sleeping quarters in the hospital’s basement and spent off-duty time socializing in the emergency department. On April 16, because of worsening symptoms, the patient was admitted to the hospital with a diagnosis of infectious enteritis (MMWR 52;461-6). On April 18, the patient became short of breath. A chest radiograph showed bilateral infiltrates, and the patient was transferred to an isolation room in the intensive care unit with suspected SARS (MMWR 52;461-6).
Because the index patient had been symptomatic for 6 days before SARS was diagnosed, the number of potentially exposed persons was estimated at 10,000 patients and visitors and 930 staff. On April 24, hospital A was contained, and all patients, visitors, and staff were quarantined within the building (MMWR 52;461-6).
Healthcare worker clusters at eight additional hospitals in Taiwan have been linked to the initial outbreak at hospital A. Preliminary data suggest that many of these clusters occurred when pre-symptomatic patients or patients with SARS symptoms attributed to other causes were discharged or transferred to other healthcare facilities. SARS later extended to multiple cities and regions of Taiwan, including several university and private hospitals. Four of these hospitals, including a 2,300-bed facility in southern Taiwan, discontinued emergency and routine services. Sporadic community cases also were reported in Taipei and southern Taiwan (MMWR 52;461-6).
The April outbreak in Taiwan may serve as an example of the farreaching consequences of one single unrecognized SARS case.
On July 5, Taiwan was removed from the list of areas with recent local transmission (WHO Update 96).
Other Countries
The number of probable SARS cases reported from other countries over the time period November 1, 2002 to July 2, 2003, is shown in the following table.
Kamps and Hoffmann (eds.)
74 Epidemiology
Country |
Cumulative number |
Number of |
Case fatality |
|
of case(s) |
deaths |
ratio (%) |
Australia |
6 |
0 |
0 |
Canada |
251 |
43 |
17 |
China |
5327 |
349 |
7 |
France |
7 |
1 |
14 |
Germany |
9 |
0 |
0 |
Hong Kong |
1755 |
299 |
17 |
India |
3 |
0 |
0 |
Indonesia |
2 |
0 |
0 |
Italy |
4 |
0 |
0 |
Kuwait |
1 |
0 |
0 |
Macao |
1 |
0 |
0 |
Malaysia |
5 |
2 |
40 |
Mongolia |
9 |
0 |
0 |
New Zealand |
1 |
0 |
0 |
Philippines |
14 |
2 |
14 |
Republic of Ireland |
1 |
0 |
0 |
Republic of Korea |
3 |
0 |
0 |
Romania |
1 |
0 |
0 |
Russian Federation |
1 |
0 |
0 |
Singapore |
238 |
33 |
14 |
South Africa |
1 |
1 |
100 |
Spain |
1 |
0 |
0 |
Sweden |
5 |
0 |
0 |
Switzerland |
1 |
0 |
0 |
Taiwan |
346 |
37 |
11 |
Thailand |
9 |
2 |
22 |
United Kingdom |
4 |
0 |
0 |
United States |
29 |
0 |
9 |
Vietnam |
63 |
5 |
8 |
|
|
|
|
Total |
8098 |
774 |
9.6 |
Notes:
The cumulative number of cases includes the number of deaths. Updated data are available at http://www.who.int/csr/sars/en/
www.SARSreference.com