- •November 16, 2002
- •February 14, 2003
- •February 21
- •February 28
- •March 7
- •March 10
- •March 12
- •March 14
- •March 15
- •March 17
- •March 19
- •March 21
- •March 24
- •March 26
- •March 28
- •March 30
- •March 31
- •April 2
- •April 2
- •April 8-10
- •April 12
- •April 16
- •April 20
- •April 20
- •April 23
- •April 25
- •April 27
- •April 29
- •June 6
- •June 13
- •June 17
- •June 21
- •June 23
- •June 24
- •July 2
- •July 5
- •August 14
- •September 8
- •September 24
- •References
- •Virology
- •Discovery of the SARS Virus
- •Initial Research
- •The Breakthrough
- •Coronaviridae
- •SARS Co-V
- •Genome Sequence
- •Morphology
- •Organization
- •Detection
- •Stability and Resistance
- •Natural Host
- •Antiviral Agents and Vaccines
- •Antiviral Drugs
- •Vaccines
- •Outlook
- •References
- •Routes of Transmission
- •Factors Influencing Transmission
- •Patient Factors in Transmission
- •Asymptomatic Patients
- •Symptomatic Patients
- •Superspreaders
- •The Unsuspected Patients
- •High-Risk Activities
- •Transmission during Quarantine
- •Transmission after Recovery
- •Animal Reservoirs
- •Conclusion
- •References
- •Introduction
- •Modeling the Epidemic
- •Starting Point
- •Global Spread
- •Hong Kong
- •Vietnam
- •Toronto
- •Singapore, February 2003
- •China
- •Taiwan
- •Other Countries
- •Eradication
- •Outlook
- •References
- •Introduction
- •International Coordination
- •Advice to travelers
- •Management of SARS in the post-outbreak period
- •National Measures
- •Legislation
- •Extended Case Definition
- •Quarantine
- •Reduce travel between districts
- •Quarantine after Discharge
- •Infection Control in Healthcare Settings
- •General Measures
- •Protective Measures
- •Hand washing
- •Gloves
- •Face Masks
- •Additional protection
- •Getting undressed
- •Special Settings
- •Intensive Care Units
- •Intubating a SARS Patient
- •Anesthesia
- •Triage
- •Internet Sources
- •Additional information
- •Infection Control in Households
- •Possible Transmission from Animals
- •After the Outbreak
- •Conclusion
- •References
- •Case Definition
- •WHO Case Definition
- •Suspect case
- •Probable case
- •Exclusion criteria
- •Reclassification of cases
- •CDC Case Definition
- •Diagnostic Tests
- •Introduction
- •Laboratory tests
- •Molecular tests
- •Virus isolation
- •Antibody detection
- •Interpretation
- •Limitations
- •Biosafety considerations
- •Outlook
- •Table, Figures
- •References
- •Clinical Presentation and Diagnosis
- •Clinical Presentation
- •Hematological Manifestations
- •Atypical Presentation
- •Chest Radiographic Abnormalities
- •Chest Radiographs
- •CT Scans
- •Diagnosis
- •Clinical Course
- •Viral Load and Immunopathological Damage
- •Histopathology
- •Lung Biopsy
- •Postmortem Findings
- •Discharge and Follow-up
- •Psychosocial Issues
- •References
- •Appendix: Guidelines
- •WHO: Management of Severe Acute Respiratory Syndrome (SARS)
- •Management of Suspect and Probable SARS Cases
- •Definition of a SARS Contact
- •Management of Contacts of Probable SARS Cases
- •Management of Contacts of Suspect SARS Cases
- •SARS Treatment
- •Antibiotic therapy
- •Antiviral therapy
- •Ribavirin
- •Neuraminidase inhibitor
- •Protease inhibitor
- •Human interferons
- •Human immunoglobulins
- •Alternative medicine
- •Immunomodulatory therapy
- •Corticosteroids
- •Other immunomodulators
- •Assisted ventilation
- •Non-invasive ventilation
- •Invasive mechanical ventilation
- •Clinical outcomes
- •Outlook
- •Appendix 1
- •A standardized treatment protocol for adult SARS in Hong Kong
- •Appendix 2
- •A treatment regimen for SARS in Guangzhou, China
- •References
- •Pediatric SARS
- •Clinical Manifestation
- •Radiologic Features
- •Treatment
- •Clinical Course
- •References
Infection Control in Healthcare Settings 95
Anesthesia
As specialists in airway management, anesthetists are routinely exposed to patients' respiratory secretions and are at high risk of contracting SARS from infected patients (Kamming).
Any known or suspected SARS patient must be regarded as ultra high risk and the attending anesthetist should wear a N95 mask, goggles, face shield, double gown, double gloves, and protective overshoes. Removal and disposal of these items without contaminating oneself is critical. The use of a powered respirator by the anesthetist and assistant is strongly advised for high-risk aerosol-generating airway procedures in suspected SARS patients (Kamming).
Triage
Identifying persons who might be at risk of SARS on arrival at a medical facility or office is difficult and requires changes in the way medical evaluations are conducted. Revised interim guidelines for triage recommend that all patients in ambulatory-care settings be screened promptly for fever, respiratory symptoms, recent travel, and close contact with a suspected SARS patient:
Updated Interim Domestic Guidelines for Triage and Disposition of Patients Who May Have Severe Acute Respiratory Syndrome (SARS) Guidance on triage screening to facilitate the identification of patients who may have SARS in the ambulatory setting: http://www.cdc.gov/ncidod/sars/triage_interim_guidance.htm
Internet Sources
Infection-control practitioners, clinicians providing medical care for patients with suspected SARS, and persons who might have contact with persons with suspected SARS should frequently consult the CDC's "SARS Infection Control and Exposure Management" guidelines (http://www.cdc.gov/ncidod/sars/ic.htm):
Updated Interim Domestic Infection Control Guidance in the Healthcare and Community Setting for Patients with Suspected SARS Precautions are recommended until the epidemiology of the disease transmission is better understood (see details below); http://www.cdc.gov/ncidod/sars/infectioncontrol.htm
Kamps and Hoffmann (eds.)
96 Prevention
Interim Domestic Guidance on the Use of Respirators to Prevent Transmission of SARS; http://www.cdc.gov/ncidod/sars/respirators.htm
Infection Control Precautions for Aerosol-Generating Procedures on Patients who have Suspected SARS; http://www.cdc.gov/ncidod/sars/aerosolinfectioncontrol.htm Precautions for procedures such as aerosolized medication treatments (e.g., albuterol), diagnostic sputum induction, bronchoscopy, airway suctioning, & endotracheal intubation.
Interim Laboratory Biosafety Guidelines for Handling and Processing Specimens Associated with SARS; http://www.cdc.gov/ncidod/sars/sarslabguide.htm
See also the article "Infection Control Guidance for Handling of Human Remains of Severe Acute Respiratory Syndrome (SARS) Decedents" published by Heath Canada at http://SARSReference.com/link.php?id=17
CDC: Updated Interim Domestic Infection Control Guidance in the Health-Care and Community Setting for Patients with Suspected SARS
Revised: May 1, 2003
Check regularly for updates: http://www.cdc.gov/ncidod/sars/infectioncontrol.htm
For all contact with suspect SARS patients, careful hand hygiene is urged, including hand washing with soap and water; if hands are not visibly soiled, alcohol-based handrubs may be used as an alternative to hand washing.
Access www.cdc.gov/handhygiene for more information on hand hygiene.
For the inpatient setting:
If a suspect SARS patient is admitted to the hospital, infection control personnel should be notified immediately. Infection control measures
www.SARSreference.com
Infection Control in Healthcare Settings 97
for inpatients (www.cdc.gov/ncidod/hip/isolat/isolat.htm) should include:
Standard precautions (e.g., hand hygiene); in addition to routine standard precautions, health-care personnel should wear eye protection for all patient contact.
Contact precautions (e.g., use of gown and gloves for contact with the patient or their environment)
Airborne precautions (e.g., an isolation room with negative pressure relative to the surrounding area and use of an N-95 filtering disposable respirator for persons entering the room)
If airborne precautions cannot be fully implemented, patients should be placed in a private room, and all persons entering the room should wear N-95 respirators. Where possible, a qualitative fit test should be conducted for N-95 respirators; detailed information on fit testing can be accessed at http://SARSReference.com/link.php?id=4. If N-95 respirators are not available for health-care personnel, then surgical masks should be worn. Regardless of the availability of facilities for airborne precautions, standard and contact precautions should be implemented for all suspected SARS patients.
For the outpatient setting:
Persons seeking medical care for an acute respiratory infection should be asked about possible exposure to someone with SARS or recent travel to a SARS-affected area. If SARS is suspected, provide and place a surgical mask over the patient’s nose and mouth. If masking the patient is not feasible, the patient should be asked to cover his/her mouth with a disposable tissue when coughing, talking or sneezing. Separate the patient from others in the reception area as soon as possible, preferably in a private room with negative pressure relative to the surrounding area.
All health-care personnel should wear N-95 respirators while taking care of patients with suspected SARS. In addition, health care personnel should follow standard precautions (e.g., hand hygiene), contact precautions (e.g., use of gown and gloves for contact with the patient or their environment) and wear eye protection for all patient contact.
Kamps and Hoffmann (eds.)