- •November 16, 2002
- •February 14, 2003
- •February 21
- •February 28
- •March 7
- •March 10
- •March 12
- •March 14
- •March 15
- •March 17
- •March 19
- •March 21
- •March 24
- •March 26
- •March 28
- •March 30
- •March 31
- •April 2
- •April 2
- •April 8-10
- •April 12
- •April 16
- •April 20
- •April 20
- •April 23
- •April 25
- •April 27
- •April 29
- •June 6
- •June 13
- •June 17
- •June 21
- •June 23
- •June 24
- •July 2
- •July 5
- •August 14
- •September 8
- •September 24
- •References
- •Virology
- •Discovery of the SARS Virus
- •Initial Research
- •The Breakthrough
- •Coronaviridae
- •SARS Co-V
- •Genome Sequence
- •Morphology
- •Organization
- •Detection
- •Stability and Resistance
- •Natural Host
- •Antiviral Agents and Vaccines
- •Antiviral Drugs
- •Vaccines
- •Outlook
- •References
- •Routes of Transmission
- •Factors Influencing Transmission
- •Patient Factors in Transmission
- •Asymptomatic Patients
- •Symptomatic Patients
- •Superspreaders
- •The Unsuspected Patients
- •High-Risk Activities
- •Transmission during Quarantine
- •Transmission after Recovery
- •Animal Reservoirs
- •Conclusion
- •References
- •Introduction
- •Modeling the Epidemic
- •Starting Point
- •Global Spread
- •Hong Kong
- •Vietnam
- •Toronto
- •Singapore, February 2003
- •China
- •Taiwan
- •Other Countries
- •Eradication
- •Outlook
- •References
- •Introduction
- •International Coordination
- •Advice to travelers
- •Management of SARS in the post-outbreak period
- •National Measures
- •Legislation
- •Extended Case Definition
- •Quarantine
- •Reduce travel between districts
- •Quarantine after Discharge
- •Infection Control in Healthcare Settings
- •General Measures
- •Protective Measures
- •Hand washing
- •Gloves
- •Face Masks
- •Additional protection
- •Getting undressed
- •Special Settings
- •Intensive Care Units
- •Intubating a SARS Patient
- •Anesthesia
- •Triage
- •Internet Sources
- •Additional information
- •Infection Control in Households
- •Possible Transmission from Animals
- •After the Outbreak
- •Conclusion
- •References
- •Case Definition
- •WHO Case Definition
- •Suspect case
- •Probable case
- •Exclusion criteria
- •Reclassification of cases
- •CDC Case Definition
- •Diagnostic Tests
- •Introduction
- •Laboratory tests
- •Molecular tests
- •Virus isolation
- •Antibody detection
- •Interpretation
- •Limitations
- •Biosafety considerations
- •Outlook
- •Table, Figures
- •References
- •Clinical Presentation and Diagnosis
- •Clinical Presentation
- •Hematological Manifestations
- •Atypical Presentation
- •Chest Radiographic Abnormalities
- •Chest Radiographs
- •CT Scans
- •Diagnosis
- •Clinical Course
- •Viral Load and Immunopathological Damage
- •Histopathology
- •Lung Biopsy
- •Postmortem Findings
- •Discharge and Follow-up
- •Psychosocial Issues
- •References
- •Appendix: Guidelines
- •WHO: Management of Severe Acute Respiratory Syndrome (SARS)
- •Management of Suspect and Probable SARS Cases
- •Definition of a SARS Contact
- •Management of Contacts of Probable SARS Cases
- •Management of Contacts of Suspect SARS Cases
- •SARS Treatment
- •Antibiotic therapy
- •Antiviral therapy
- •Ribavirin
- •Neuraminidase inhibitor
- •Protease inhibitor
- •Human interferons
- •Human immunoglobulins
- •Alternative medicine
- •Immunomodulatory therapy
- •Corticosteroids
- •Other immunomodulators
- •Assisted ventilation
- •Non-invasive ventilation
- •Invasive mechanical ventilation
- •Clinical outcomes
- •Outlook
- •Appendix 1
- •A standardized treatment protocol for adult SARS in Hong Kong
- •Appendix 2
- •A treatment regimen for SARS in Guangzhou, China
- •References
- •Pediatric SARS
- •Clinical Manifestation
- •Radiologic Features
- •Treatment
- •Clinical Course
- •References
168 Pediatric SARS
Chapter 10: Pediatric SARS
Bernd Sebastian Kamps, Christian Hoffmann
Clinical Manifestation
Two studies have so far reported on SARS among children. In one study, persistent fever, cough, progressive chest radiograph changes and lymphopenia were noted in all 10 patients (Hon). Teenage patients presented with symptoms of malaise, myalgia, chill, and rigor similar to those seen in adults, whereas the younger children presented mainly with a cough and runny nose, and none had chills, rigor, or myalgia.
In the second study, fever was the presenting symptom in 19 of 21 children. Other prodromal symptoms reported included malaise, loss of appetite, chills, dizziness, and rhinorrhea. Headache, myalgia, diarrhea, sore throat, and skin rash were relatively uncommon (Chiu; Table 1). During the lower respiratory phase of the illness, approximately one half of the children had coughing, one third of which was productive. Dyspnea or tachypnea was uncommon (Chiu).
At presentation, all 21 children had normal hemoglobin values. The total white cell count was low in five children (23.8%). All neutrophil counts were normal. Twelve children (57.1%) had lymphopenia, and five (23.8%) had thrombocytopenia (Chiu). Subsequently, during the course of the disease, 19 children (90.5%) developed lymphopenia and ten of them (47.6%) had mild thrombocytopenia. All elevated activated partial thromboplastin time levels during the acute phase in six children (28.6%) subsequently returned to normal levels. D-dimer was abnormal in three children (14.3%). All children had normal renal function. Abnormal ALT levels were found in two children (9.5%) at admission. Mild biochemical hepatitis, defined as an elevation three times that of a normal ALT level with a normal bilirubin level, was observed in five children (23.8%). Fifteen children (71.4%) had a raised LDH level, and nine children (42.9%) had a raised CPK level (Chiu).
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Pediatric SARS 169
Table 1. Clinical features of children with severe acute respiratory syndrome*
Features |
No. of Children (%) |
|
Fever |
19 (90.5) |
|
Malaise |
13 (61.9) |
|
Loss of appetite |
12 (57.1) |
|
Chills |
10 (47.6) |
|
Cough |
9 |
(42.9) |
Dizziness |
8 |
(38.1) |
Rhinorrhea |
7 |
(33.3) |
Sputum |
3 |
(14.3) |
Dyspnea/tachypnea |
3 |
(14.3) |
Headache |
3 |
(14.3) |
Myalgia |
2 |
(9.5) |
Diarrhea |
2 |
(9.5) |
Sore throat |
1 |
(4.8) |
Rash |
1 |
(4.8) |
* from Chiu: Severe acute respiratory syndrome in children: experience in a regional hospital in Hong Kong
When comparing the 11 children below 12 years with the ten children 12 years and older, the older group had less cough. However, these children had higher temperatures, a longer duration of fever, and more constitutional upset in terms of malaise and dizziness. They had more derangement in laboratory variables, including platelet counts, ALT, LDH, and CPK. All of them received steroid treatment. The changes in their chest radiographs took a longer time to resolve (Chiu).
Radiologic Features
In the same series (Chiu), pneumonic changes on chest radiographs were present in ten children (47.6%) at admission, but all 21 children developed abnormal chest radiographs during the course of the disease. The primary radiological abnormality was airspace opacity. Unilateral focal opacity was the most common presentation and was found in 18 children (85.7%). Two children (9.5%) had unilateral multi-focal opacities, and one child (4.8%) had bilateral involvement. There was no particular distribution pattern. Peripheral zone involvement was found in six children (28.6%). The opacities found in the
Kamps and Hoffmann (eds.)
170 Pediatric SARS
chest radiographs of the children showed evidence of progression, with an increase in the size or involvement of multiple areas in 18 children (85.7%). Bilateral involvement was observed in ten children (47.6%). Chest radiographic abnormalities were worst on day 6.5 +/- 2.7 days after admission. Two children (9.5%) had high-resolution computerized tomography of the thorax done because of a high clinical suspicion of SARS, although chest radiographs were initially negative. Both tomographs were abnormal and showed the characteristic ground-glass opacities, as described previously in adults (Chiu).
Treatment
The treatment protocol proposed by Hon et al. is shown in Table 2. In this series, four teenagers required oxygen therapy and two needed assisted ventilation, whereas none of the younger children required oxygen supplementation (Hon). Among the 21 children reported by Chiu, only two children (9.5%) required supplemental oxygen. None of them required mechanical ventilation.
Table 2. Treatment of children with SARS*
Diagnosis of SARS sus- |
Intravenous cefotaxime, oral clarithromycin, and |
pected on admission |
oral ribavirin** (40 mg/kg daily, given in two or |
|
three doses) |
Fever persists >48 h |
Oral prednisolone** (0·5 mg/kg daily to 2·0 mg/kg |
|
daily) |
Patients with moderate |
Intravenous ribavirin** (20 mg/kg daily, given in |
symptoms of high fluctu- |
three doses) and hydrocortisone** (2 mg/kg every |
ating fever and notable |
6 h) immediately after admission |
malaise |
|
Persistent fever and |
Pulse intravenous methylprednisolone (10–20 |
progressive worsening |
mg/kg) |
clinically or radiologically |
|
*from Hon: Clinical presentations and outcome of severe acute respiratory syndrome in children.
**Ribavirin was administered for 1–2 weeks and corticosteroid dose was tapered over 2–4 weeks.
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Pediatric SARS 171
Clinical Course
The clinical course seems to be much milder and shorter among patients less than 12 years of age (Hon, Chiu). In addition, the radiological changes are milder and generally resolve more quickly than in teenagers. Compared with adults and teenagers, SARS seems to have a less aggressive clinical course in younger children (Hon, Chiu). The reason why children with SARS fare better than adults and adolescents infected with the disease is unclear.
References
1.Chiu WK, Cheung PC, Ng CK, et al. Severe acute respiratory syndrome in children: experience in a regional hospital in Hong Kong. Pediatr Crit Care Med 2003; 4: 279-83. http://SARSReference.com/lit.php?id=12831407
2.Health, Welfare & Food Bureau. SARS Bulletin 25 April 2003. (accessed on April 27) http://www.info.gov.hk/dh/diseases/ap/eng/bulletin0425.htm
3.Hon KL, Leung CW, Cheng WT, et al. Clinical presentations and outcome of severe acute respiratory syndrome in children. Lancet 2003, 361:1701-3. Published online April 29, 2003. http://image.thelancet.com/extras/03let4127web.pdf
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