- •Analysis and Application of Analog Electronic Circuits to Biomedical Instrumentation
- •Dedication
- •Preface
- •Reader Background
- •Rationale
- •Description of the Chapters
- •Features
- •The Author
- •Table of Contents
- •1.1 Introduction
- •1.2 Sources of Endogenous Bioelectric Signals
- •1.3 Nerve Action Potentials
- •1.4 Muscle Action Potentials
- •1.4.1 Introduction
- •1.4.2 The Origin of EMGs
- •1.5 The Electrocardiogram
- •1.5.1 Introduction
- •1.6 Other Biopotentials
- •1.6.1 Introduction
- •1.6.2 EEGs
- •1.6.3 Other Body Surface Potentials
- •1.7 Discussion
- •1.8 Electrical Properties of Bioelectrodes
- •1.9 Exogenous Bioelectric Signals
- •1.10 Chapter Summary
- •2.1 Introduction
- •2.2.1 Introduction
- •2.2.4 Schottky Diodes
- •2.3.1 Introduction
- •2.4.1 Introduction
- •2.5.1 Introduction
- •2.5.5 Broadbanding Strategies
- •2.6 Photons, Photodiodes, Photoconductors, LEDs, and Laser Diodes
- •2.6.1 Introduction
- •2.6.2 PIN Photodiodes
- •2.6.3 Avalanche Photodiodes
- •2.6.4 Signal Conditioning Circuits for Photodiodes
- •2.6.5 Photoconductors
- •2.6.6 LEDs
- •2.6.7 Laser Diodes
- •2.7 Chapter Summary
- •Home Problems
- •3.1 Introduction
- •3.2 DA Circuit Architecture
- •3.4 CM and DM Gain of Simple DA Stages at High Frequencies
- •3.4.1 Introduction
- •3.5 Input Resistance of Simple Transistor DAs
- •3.7 How Op Amps Can Be Used To Make DAs for Medical Applications
- •3.7.1 Introduction
- •3.8 Chapter Summary
- •Home Problems
- •4.1 Introduction
- •4.3 Some Effects of Negative Voltage Feedback
- •4.3.1 Reduction of Output Resistance
- •4.3.2 Reduction of Total Harmonic Distortion
- •4.3.4 Decrease in Gain Sensitivity
- •4.4 Effects of Negative Current Feedback
- •4.5 Positive Voltage Feedback
- •4.5.1 Introduction
- •4.6 Chapter Summary
- •Home Problems
- •5.1 Introduction
- •5.2.1 Introduction
- •5.2.2 Bode Plots
- •5.5.1 Introduction
- •5.5.3 The Wien Bridge Oscillator
- •5.6 Chapter Summary
- •Home Problems
- •6.1 Ideal Op Amps
- •6.1.1 Introduction
- •6.1.2 Properties of Ideal OP Amps
- •6.1.3 Some Examples of OP Amp Circuits Analyzed Using IOAs
- •6.2 Practical Op Amps
- •6.2.1 Introduction
- •6.2.2 Functional Categories of Real Op Amps
- •6.3.1 The GBWP of an Inverting Summer
- •6.4.3 Limitations of CFOAs
- •6.5 Voltage Comparators
- •6.5.1 Introduction
- •6.5.2. Applications of Voltage Comparators
- •6.5.3 Discussion
- •6.6 Some Applications of Op Amps in Biomedicine
- •6.6.1 Introduction
- •6.6.2 Analog Integrators and Differentiators
- •6.7 Chapter Summary
- •Home Problems
- •7.1 Introduction
- •7.2 Types of Analog Active Filters
- •7.2.1 Introduction
- •7.2.3 Biquad Active Filters
- •7.2.4 Generalized Impedance Converter AFs
- •7.3 Electronically Tunable AFs
- •7.3.1 Introduction
- •7.3.3 Use of Digitally Controlled Potentiometers To Tune a Sallen and Key LPF
- •7.5 Chapter Summary
- •7.5.1 Active Filters
- •7.5.2 Choice of AF Components
- •Home Problems
- •8.1 Introduction
- •8.2 Instrumentation Amps
- •8.3 Medical Isolation Amps
- •8.3.1 Introduction
- •8.3.3 A Prototype Magnetic IsoA
- •8.4.1 Introduction
- •8.6 Chapter Summary
- •9.1 Introduction
- •9.2 Descriptors of Random Noise in Biomedical Measurement Systems
- •9.2.1 Introduction
- •9.2.2 The Probability Density Function
- •9.2.3 The Power Density Spectrum
- •9.2.4 Sources of Random Noise in Signal Conditioning Systems
- •9.2.4.1 Noise from Resistors
- •9.2.4.3 Noise in JFETs
- •9.2.4.4 Noise in BJTs
- •9.3 Propagation of Noise through LTI Filters
- •9.4.2 Spot Noise Factor and Figure
- •9.5.1 Introduction
- •9.6.1 Introduction
- •9.7 Effect of Feedback on Noise
- •9.7.1 Introduction
- •9.8.1 Introduction
- •9.8.2 Calculation of the Minimum Resolvable AC Input Voltage to a Noisy Op Amp
- •9.8.5.1 Introduction
- •9.8.5.2 Bridge Sensitivity Calculations
- •9.8.7.1 Introduction
- •9.8.7.2 Analysis of SNR Improvement by Averaging
- •9.8.7.3 Discussion
- •9.10.1 Introduction
- •9.11 Chapter Summary
- •Home Problems
- •10.1 Introduction
- •10.2 Aliasing and the Sampling Theorem
- •10.2.1 Introduction
- •10.2.2 The Sampling Theorem
- •10.3 Digital-to-Analog Converters (DACs)
- •10.3.1 Introduction
- •10.3.2 DAC Designs
- •10.3.3 Static and Dynamic Characteristics of DACs
- •10.4 Hold Circuits
- •10.5 Analog-to-Digital Converters (ADCs)
- •10.5.1 Introduction
- •10.5.2 The Tracking (Servo) ADC
- •10.5.3 The Successive Approximation ADC
- •10.5.4 Integrating Converters
- •10.5.5 Flash Converters
- •10.6 Quantization Noise
- •10.7 Chapter Summary
- •Home Problems
- •11.1 Introduction
- •11.2 Modulation of a Sinusoidal Carrier Viewed in the Frequency Domain
- •11.3 Implementation of AM
- •11.3.1 Introduction
- •11.3.2 Some Amplitude Modulation Circuits
- •11.4 Generation of Phase and Frequency Modulation
- •11.4.1 Introduction
- •11.4.3 Integral Pulse Frequency Modulation as a Means of Frequency Modulation
- •11.5 Demodulation of Modulated Sinusoidal Carriers
- •11.5.1 Introduction
- •11.5.2 Detection of AM
- •11.5.3 Detection of FM Signals
- •11.5.4 Demodulation of DSBSCM Signals
- •11.6 Modulation and Demodulation of Digital Carriers
- •11.6.1 Introduction
- •11.6.2 Delta Modulation
- •11.7 Chapter Summary
- •Home Problems
- •12.1 Introduction
- •12.2.1 Introduction
- •12.2.2 The Analog Multiplier/LPF PSR
- •12.2.3 The Switched Op Amp PSR
- •12.2.4 The Chopper PSR
- •12.2.5 The Balanced Diode Bridge PSR
- •12.3 Phase Detectors
- •12.3.1 Introduction
- •12.3.2 The Analog Multiplier Phase Detector
- •12.3.3 Digital Phase Detectors
- •12.4 Voltage and Current-Controlled Oscillators
- •12.4.1 Introduction
- •12.4.2 An Analog VCO
- •12.4.3 Switched Integrating Capacitor VCOs
- •12.4.6 Summary
- •12.5 Phase-Locked Loops
- •12.5.1 Introduction
- •12.5.2 PLL Components
- •12.5.3 PLL Applications in Biomedicine
- •12.5.4 Discussion
- •12.6 True RMS Converters
- •12.6.1 Introduction
- •12.6.2 True RMS Circuits
- •12.7 IC Thermometers
- •12.7.1 Introduction
- •12.7.2 IC Temperature Transducers
- •12.8 Instrumentation Systems
- •12.8.1 Introduction
- •12.8.5 Respiratory Acoustic Impedance Measurement System
- •12.9 Chapter Summary
- •References
The Differential Amplifier |
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GAIN |
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DABJTCM |
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Temperature = 27 |
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−180.0 |
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−12.00 |
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−234.0 |
−24.00 |
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−288.0 |
−36.00 |
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−342.0 |
−48.00 |
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−396.0 |
−60.00 |
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−450.0 |
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100K |
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1M |
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10M |
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Frequency in Hz |
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(A) |
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GAIN |
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DABJTCM |
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Temperature = 27 |
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Case = 1 |
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0.00 |
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−180.0 |
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−12.00 −234.0
−24.00 −288.0
−36.00 −342.0
−48.00 −396.0
−60.00 |
100K |
1M |
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1G |
Frequency in Hz
(B)
FIGURE 3.10
Common-mode gain frequency response of the BJT DA of Figure 3.6A with various values of parasitic emitter capacitance, Ce, showing how Ce can improve the DA’s CMRR by giving a low CM gain at high frequencies. (A) CM gain frequency response (FR) with Ce = 0. (B) CM gain FR with an optimum Ce = 4 pF. (C) CM gain FR with Ce = 4.2 pF. (D) CM gain FR with Ce = 3.8 pF.
3.5Input Resistance of Simple Transistor DAs
In general, simple, two-transistor DAs have much lower Rin for DM signals than for CM inputs; this is true over the entire frequency range of the DA. This effect is more pronounced for BJT DA stages than for JFET or MOSFET DAs. By way of illustration, consider the CM HIFSSM of the BJT amplifier
© 2004 by CRC Press LLC
154 |
Analysis and Application of Analog Electronic Circuits |
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GAIN |
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DABJTCM |
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PHASE |
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Temperature = 27 |
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Case = 1 |
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Frequency in Hz |
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(C) |
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DABJTCM |
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Frequency in Hz
(D)
FIGURE 3.10 (continued)
illustrated in Figure 3.6(A). When Rin( f ) DM = Vsc/Isc is plotted using MicroCap, at low frequencies Rin rπ + rx = 3 E3 ohms, and it begins to roll off at approximately 100 kHz. On the other hand, when the CM HIFSSM of Figure 3.6(B) is stimulated, the low frequency Rin( f ) CM 3 E8 ohms, or 2RE (1 + gm rπ), a sizeable increase over the DM Rin( f ) . The low-frequencyRin( f ) CM begins to roll off at only 200 Hz.
Ideally, the Rin( f ) for both CM and DM would be very large, to prevent loading of the sources driving the DA. High Rin( f ) DM can be achieved in several ways. One way is to insert a resistor Re′ between the emitter of each BJT and the Ve node (see Figure 3.5). It is easy to show from the midfrequency, common-emitter h-parameter MFSSM of the BJT DA for DM
inputs (see Figure 3.11(B)) that RinDM = Vsd/Ib = hie + Re′ (1 + β). The practical upper bound on Re′ is set by dc biasing considerations. The small-signal
input resistance, hie, can be shown to be approximated by:
© 2004 by CRC Press LLC
The Differential Amplifier |
155 |
+Vcc
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FIGURE 3.11
(A) A BJT DA with extra emitter resistances, R1, which lower DM gain and increase DM input resistance. (B) Simplified MFSSM of the left side of the DA given DM inputs. (C) Simplified MFSSM of the left side of the DA given CM inputs.
hie VT β/ICQ |
(3.20) |
where VT = kT/q; β is the transistor’s current gain, hfe; and ICQ is the collector current at the BJT’s quiescent (Q) operating point.
Another approach is to use BJT Darlington amplifiers in the DA; a Darlington circuit and its simplified MFSSM are shown in Figure 3.12. Darlingtons can easily be shown to have an input resistance of:
© 2004 by CRC Press LLC
156 |
Analysis and Application of Analog Electronic Circuits |
VCC
Rc
Q1
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FIGURE 3.12
(A) A Darlington stage that can replace the left-hand BJT in the DA of Figure 3.11A. (B) MFSSM of the Darlington valid for DM excitation of the DA. The input resistance for the Darlington DA given DM excitation is derived in the text.
Rin = hie1 + hie2(1 + β1) |
(3.21) |
If an emitter resistor, R1, is used as in the first case, Rin can be shown to be:
Rin = hie1 + (1 + hfe1)[hie2 + R1(1 + hfe2)] hfe1 hfe2 R1 |
(3.22) |
Thus, if hfe1 = hfe2 = 100 and R1 = 200 Ω, Rin > 2 MΩ.
© 2004 by CRC Press LLC
The Differential Amplifier |
157 |
Another obvious way to increase Rin for DM excitation (and CM as well) is to design the DA headstage using JFETs or MOSFETs. Using these devices, the lowand mid-frequency Rin is on the order of 109 to 1012 Ω.
3.6How Signal Source Impedance Affects Low-Frequency CMRR
Figure 3.13 illustrates a generalized input circuit for an instrumentation DA. Note that the two Thevenin sources, vs and vs′ can be broken into DM and CM components. As defined earlier:
vsd ∫ (vs − vs′)/2 |
(3.23A) |
vsc ∫ (vs + vs′)/2 |
(3.23B) |
Superposition is used to compute the effects of vsc and vsd on the output of the DA. When vsc is considered, vs and vs′ are replaced with vsc in Figure 3.13; when vsd is considered, vs is replaced with vsd and vs′ with −vsd. Note that manufacturers usually specify a common-mode input impedance, Zic, measured from one input lead to ground under pure CM excitation, and a difference-mode input impedance, Zid, measured under pure DM excitation from either input to ground. The input Zs are generally given by manufacturer’s specs as a resistance in parallel with a small shunting capacitance, for example, Zic as 1011 Ω 5 pF. In the following development, the signal frequency is assumed to be sufficiently low so that the currents through the input capacitances are negligible compared to the parallel input resistance. Thus, only input resistances are used.
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FIGURE 3.13
A generalized input equivalent circuit for a DA.
© 2004 by CRC Press LLC
158 |
Analysis and Application of Analog Electronic Circuits |
By Ohm’s law, the DM current into the noninverting input node is just:
id = 2vsd/R1 + vsd/Ric |
(3.24) |
From which, |
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id/vsd = 1/Rsd = 2/R1 + 1/Ric |
(3.25) |
can be written. Solving for the equivalent shunting resistance in Equation 3.25 yields:
R1 = 2 Rid Ric/(Ric − Rid) |
(3.26) |
In many differential amplifiers, Ric > Rid. In others, Ric Rid and, from Equation 3.26, R1 = •. Thus,
Zic = Zid Ric |
(3.27) |
Assume that Ric = Rid. Thus, R1 may be eliminated from Figure 3.13, which illustrates two Thevenin sources driving the DA through unequal source resistances, Rs and Rs + R.
Using superposition and the definitions in Equation 3.23A and Equation 3.23B, it is possible to show that a purely CM excitation, vsc, produces an
unwanted difference-mode component at the DA’s input terminals: |
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sc |
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and |
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In order to find the CMRR of the circuit of Figure 3.13, Equation 3.2 will be used for vo, and the definition for CMRR, Relation 3.13. Thus:
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+ A |
C |
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and |
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C |
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sd |
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ic |
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© 2004 by CRC Press LLC
The Differential Amplifier |
159 |
∞
CMRRSYS
CMRRA
- ic /Rs + |
0 |
∆R/Rs |
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CMRRA
FIGURE 3.14
The CMRR of a balanced input DA as a function of the incremental change in one input (Thevenin) resistance. Note that a critical value of R/Rs exists that theoretically gives infinite CMRR.
After some algebra, the circuit’s CMRR, CMRRsys, is given by
CMRRsys = [AD + AC R2(Ric + Rs )][AD R2(Ric + Rs ) + AC ] (3.34)
Equation 3.34 may be reduced to the hyperbolic relation:
CMRRsys = [(AD AC ) + R 2(Ric + Rs )] [(AD |
AC ) R 2(Ric + Rs ) + 1] (3.35) |
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which can be approximated by: |
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CMRRsys |
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CMRRA |
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2(Ric + Rs ) |
in which the manufacturer-specified CMRR is CMRRA = AD/AC, and CMRRA R/2(Ric + R).
© 2004 by CRC Press LLC