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Литература

  1. Barr, L. C., Goodman, W. K., et al. The serotonin hypothesis of obsessive-compulsive disorder: Implications of pharmacologic challenge studies. J. Clin. Psychiatry 53 (4 [Suppl]):17-28, 1992.

  2. Benkelfat, C., Murphy, D. L., et al. Clomipramine in obsessive-compulsive disorder: Further evidence for a serotonergic mechanism of action. Arch. Gen. Psychiatry 46:23-28, 1989.

  3. Chouinard, G., Goodman, W. K., et al. Results of a double-blind placebo controlled trial of a new serotonin uptake inhibitor, sertraline, in the treatment of obsessive-compulsive disorder. Psychopharmacol. Bull. 26:279-284, 1990.

  4. Dominguez, R. A., Jacobson, A. F., et al. Drug response assessed by the modified Maudsley obsessive-compulsive inventory. Psychopharmacol. Bull. 25:215-218, 1989.

  5. Flament, M. F., Rapoport, J. L., et al. Clomipramine treatment of childhood obsessive-compulsive disorder: a double-blind controlled study. Arch. Gen. Psychiatry 42:977-983, 1985.

  6. Fontaine, F., Chouinard, G. An open trial of fluoxetine in the treatment of obsessive-compulsive disorder. J. Clin. Psychopharmacol. 6:98-101, 1986.

  7. Goodman, W. K., Price, L. H., et al. Efficacy of fluvoxamine in obsessive-compulsive disorder. A double-blind comparison with placebo. Arch. Gen. Psychiatry 46:36-44, 1989.

  8. Goodman, W. K., Price, L. H., et al. The Yale-Brown obsessive-compulsive scale. 1. Development, use, and reliability. Arch. Gen. Psychiatry 46:1006-1011, 1989.

  9. Greist, J. H. Treatment of obsessive-compulsive disorder: Psychotherapies, drugs, and other somatic treatments. J. Clin. Psychiatry 51(8 [Suppl]):44-50, 1990.

  10. Hollander, E., Mullen, L., DeCaria, C. M. Obsessive-compulsive disorder, depression, and fluoxetine. J. Clin. Psychiatry 52:418-422, 1991.

  11. Hewlett, A., Vinogradov, S., Agras, W. S. Clonazepam treatment of obsessions and compulsions. J. Clin. Psychiatry 51:158-161, 1990.

  12. Hewlett, W. A., Vinogradov, S., Agras, W. S. Clomipramine, clonazepam, and clonidine treatment of obsessive-compulsive disorder. J. Clin. Psychopharmacol. 12:420-430, 1992.

  13. Jenike, M. A., Baer, L., et al. Sertraline in obsessive-compulsive disorder: A double-blind comparison with placebo. Am. J. Psychiatry 147:923-928, 1990.

  14. Jenike, M. A., Buttolph, L., et al. Open trial of fluoxetine in obsessive-compulsive disorder. Am. J. Psychiatry 146:909-911, 1989.

  15. Jenike, M. A., Hyman, S., et al. A controlled trial of fluvoxamine in obsessive-compulsive disorder: Implications for a serotonergic theory. Am. J. Psychiatry 147:1209-1215, 1990.

  16. Karno, M., Golding, J. M., et al. The epidemiology of obsessive-compulsive disorder in five US communities. Arch. Gen. Psychiatry 45:1094-1099, 1988.

  17. Leonard, H. L., Swedo, S. E., et al. Treatment of obsessive-compulsive disorder with clomipramine and desipramine in children and adolescents. A double-blind crossover comparison. Arch. Gen. Psychiatry 46:1088-1092, 1989.

  18. Levine, R., Hoffman, J. S., et al. Long-term fluoxetine treatment of a large number of obsessive-compulsive patients. J. Clin. Psychopharmacol. 9:281-283, 1989.

  19. Liebowitz, M. R., Hollander, E., et al. Fluoxetine treatment of obsessive-compulsive disorder: An open clinical trial. J. Clin. Psychopharmacol. 9:281-283, 1989.

  20. Murphy, D. L., Pigott, T. A. Obsessive-compulsive disorder: Treatment with serotonin-selective uptake inhibitors, azapirones, and other agents. J. Clin. Psychopharmacol. 10 (Suppl):91S-100S, 1990.

  21. Perse, T. L., Greist, J. H., et al. Fluvoxamine treatment of obsessive-compulsive disorder. Am. J. Psychiatry 144:1543-1548, 1987.

  22. Rasmussen, S. A., Eisen, J. L. Epidemiology of obsessive-compulsive disorder. J. Clin. Psychiatry 51:10-13, 1990.

  23. The Clomipramine Collaborative Study Group. Clomipramine in the treatment of patients with obsessive-compulsive disorder. Arch. Gen. Psychiatry 48:730-738, 1991.

  24. Turner, S. M., Jacob, R. G., et al. Fluoxetine treatment of obsessive-compulsive disorder. J. Clin. Psychopharmacol. 5:207-212, 1985.

  25. Volavka, J., Neziroglu, F., et al. Clomipramine and imipramine in obsessive-compulsive disorder. Psychiatry Res. 14:85-93, 1984.

  26. Zohar, J., Insel, T. R., et al. Serotonergic responsivity in obsessive-compulsive disorder: Effects of chronic clomipramine treatment. Arch. Gen. Psychiatry 45:167-172, 1988.

Автор благодарит Дж. Грейста за советы и критические замечания, а особенно за поддержку той оценки, которую автор дает поведенческой психотерапии как методу лечения невроза навязчивых состояний.

Таблица 5.1. Средства для лечения невроза навязчивых состояний

Препарат(а)

Начальная доза, мг/сут

^ Поддерживающая доза, мг/сут

Средняя поддерживающая доза, мг/сут

Кломипрамин

25

150-250

150

Флуоксетин

20(б)

10-80

60

(а) Оба препарата применяют внутрь. (б) По опыту автора, переносимость флуоксетина повышается, если начать с дозы 5 мг/сут, а капсулы растворять в воде или в апельсиновом соке.

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